{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:54:10Z","timestamp":1781182450880,"version":"3.54.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to examine the incidence of atrial fibrillation in patients with an accessory pathway (AP) and its association with transient ischemic attack (TIA)\/stroke as well as mortality over long-term follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1,302 consecutive patients who underwent first-time ablation AP between 2005 and 2018 were included from the Karolinska Ablation Registry and followed up through the National Patient Registry and Cause of Death Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were 41.7\u2009\u00b1\u200915.7 years old and 60.9% were men. New-onset or recurrence of atrial fibrillation occurred in 111 patients (8.5%) after a follow-up of up to 10 years (median 6.8 years; interquartile range 3.9\u20139.9 years). Multivariable analysis revealed that a history of atrial fibrillation, hyperlipidemia, a higher BMI, and older age were independently associated with new-onset or recurrence of atrial fibrillation during follow-up. All-cause mortality and TIA\/stroke occurred in 35 patients (2.7%) and 28 patients (2.2%) after a follow-up of 10 years, respectively. Multivariable analysis revealed that the occurrence of atrial fibrillation during follow-up was independently associated with both outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large patient cohort with ablated APs, long-term follow-up revealed a high incidence of atrial fibrillation with 8.5%. Occurrence of atrial fibrillation during follow-up was independently associated with both all-cause mortality and TIA\/stroke. Hence, closer monitoring for atrial fibrillation is advisable in patients with ablated APs, especially in those with a prior history of atrial fibrillation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2025.1639305","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:33:29Z","timestamp":1756964009000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of atrial fibrillation and its association with long-term outcome in patients with an accessory pathway"],"prefix":"10.3389","volume":"12","author":[{"given":"Gesa","family":"von Olshausen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Schwieler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Bastani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Bourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ott","family":"Saluveer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Drca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Paul-Nordin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Charitakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahd","family":"Asaad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Saygi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Turkmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Svennberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"\u00c5kerstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jensen-Urstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frieder","family":"Braunschweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.hrthm.2004.05.007","article-title":"Influence of age and gender on the mechanism of supraventricular tachycardia","volume":"1","author":"Porter","year":"2004","journal-title":"Heart Rhythm"},{"key":"B2","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1093\/eurheartj\/ehz467","article-title":"2019 ESC guidelines for the management of patients with supraventricular tachycardia. 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