{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:05:29Z","timestamp":1790107529813,"version":"4.0.1"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Cardiac tumors constitute an exceptionally rare neoplastic entity posing significant diagnostic challenges. We report a 55-year-old female patient without prior oncologic history who presented with acute-onset bilateral lower extremity edema progressing over 72\u2005h. Transthoracic echocardiography demonstrated a pericardial mass with concomitant hemorrhagic pericardial effusion. Subsequent magnetic resonance imaging and systemic positron emission tomography localized the lesion to the right bottom of the heart. Surgical exploration suggested a cardiac occupancy as an irregular, fish-flesh-like soft tissue mass, pathology biopsy was performed suggesting a malignant tumour of epithelial origin, and immunohistochemistry was suggestive of hepatic origin. The patient received combination therapy comprising programmed death-1 inhibitor camrelizumab (200\u2005mg via intravenous infusion every 21 days) and oral lenvatinib (8\u2005mg once daily). Serial contrast-enhanced computed tomography of the thorax and abdomen demonstrated progressive metastatic dissemination with malignant pleural and peritoneal effusion formation. Despite therapeutic intervention, the patient ultimately experienced disease progression culminating in mortality.<\/jats:p>","DOI":"10.3389\/fcvm.2025.1643805","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T05:32:26Z","timestamp":1758173546000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A case report of hepatocarcinoma-originated pericardial malignancy"],"prefix":"10.3389","volume":"12","author":[{"given":"Bin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhe","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1097\/JTO.0b013e3181e59a91","article-title":"Cardiac sarcomas: an update","volume":"5","author":"Orlandi","year":"2010","journal-title":"J Thorac Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e5544","DOI":"10.1097\/MD.0000000000005544","article-title":"Isolated metastasis of hepatocellular carcinoma in the right ventricle: a case report","volume":"95","author":"Kim","year":"2016","journal-title":"Medicine"},{"key":"B3","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s12328-019-01075-6","article-title":"Isolated cardiac metastases of hepatocellular carcinoma after resection: a case report","volume":"13","author":"Tamura","year":"2020","journal-title":"Clin J Gastroenterol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"485","DOI":"10.2217\/fca.15.10","article-title":"Malignant cardiac tumors: diagnosis and treatment","volume":"11","author":"Lestuzzi","year":"2015","journal-title":"Future Cardiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1001\/jamasurg.2022.7989","article-title":"Management of hepatocellular carcinoma: a review","volume":"158","author":"Brown","year":"2023","journal-title":"JAMA Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1136\/jcp.2005.035105","article-title":"Cardiac metastases","volume":"60","author":"Bussani","year":"2006","journal-title":"J Clin Pathol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1007\/s00330-002-1519-7","article-title":"Extrahepatic spread of hepatocellular carcinoma: a pictorial review","volume":"13","author":"Hong","year":"2003","journal-title":"Eur Radio"},{"key":"B8","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat Rev Dis Primers"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1643805\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T05:32:27Z","timestamp":1758173547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1643805\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":8,"alternative-id":["10.3389\/fcvm.2025.1643805"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2025.1643805","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,18]]},"article-number":"1643805"}}