{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:51:10Z","timestamp":1787997070842,"version":"build-2784847793"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Clinical management of primary antiphospholipid syndrome (PAPS) complicated by acute myocardial infarction (AMI) is particularly challenging, especially when recurrent AMI and thrombocytopenia are present. This case report describes a 35-year-old male patient with PAPS who experienced two episodes of acute inferior ST-elevation myocardial infarction (STEMI). Comprehensive diagnostic evaluations including coronary imaging, physiology, immunology, bone marrow morphology, and molecular biology were performed to confirm the diagnosis. A personalized treatment regimen combining clopidogrel, low-molecular-weight heparin, methylprednisolone, hydroxychloroquine, and rituximab was administered, which resulted in a favorable long-term prognosis. This case underscores the importance of a multidisciplinary approach and individualized treatment strategies based on coronary functional assessment for managing patients with PAPS and AMI.<\/jats:p>","DOI":"10.3389\/fcvm.2025.1656890","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T06:54:45Z","timestamp":1767768885000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary antiphospholipid syndrome complicated by recurrent acute ST-elevation myocardial infarction: a case 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