{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:11:48Z","timestamp":1772723508328,"version":"3.50.1"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neonatal intracardiac thrombosis (ICT) is an uncommon but increasingly recognized condition that impacts neonatal morbidity and mortality, especially in critically ill term and preterm infants. Management includes supportive care and pharmacological or surgical intervention. This study explores the challenges associated with ICT in neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We described the clinical presentation and multidisciplinary management of two cases of intracardiac thrombosis. We also reviewed literature from Medline and PubMed using MeSH terms (\u201cintracardiac thrombosis\u201d AND \u201cnewborn\u201d).<\/jats:p><\/jats:sec><jats:sec><jats:title>Case series<\/jats:title><jats:p>In the first case, a very early (day 1) atrial thrombosis was unusually attached at the fossa ovalis and floating between the right and left atrium in an early-term newborn with meconium-aspiration syndrome and fetal inflammatory response syndrome. In the second case, a late-preterm neonate developed a left atrial thrombus after resuscitation at birth, with severe anemia (hemoglobin 5\u2005g\/dl) requiring two blood transfusions. In both cases, treatment with low-molecular-weight heparin resolved the thrombus without complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Critically ill term and preterm neonates should be carefully monitored due to the increased risk of thromboembolic events. The timing and decision to treat ICTs remain challenging. Supportive therapy is always indicated, including treatment of conditions such as sepsis, dehydration, anemia, and coagulopathy. Anticoagulant therapy with low-molecular-weight heparin (LMWH) offers a favorable risk\/benefit ratio, except in neonates at high hemorrhagic risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neonatal intracardiac thrombosis, though rare, requires high clinical suspicion and prompt multidisciplinary management. Early diagnosis and individualized anticoagulant therapy can lead to favorable outcomes while minimizing complications.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2025.1659312","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T05:31:30Z","timestamp":1754458290000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Management of intracardiac thrombosis in newborns: a case series and a narrative review of the literature"],"prefix":"10.3389","volume":"12","author":[{"given":"Domenico Umberto","family":"De Rose","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Mecarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosimo Marco","family":"Campanale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaminia","family":"Pugnaloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Passarella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelio","family":"Secinaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Bracaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Luciani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Toscano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma","family":"Capolupo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Dotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.2147\/vhrm.s4274","article-title":"Thrombosis in the critically ill neonate: incidence, diagnosis, and management","volume":"4","author":"Veldman","year":"2008","journal-title":"Vasc Health Risk Manag"},{"key":"B2","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3390\/diagnostics13040764","article-title":"Intracardiac thrombi in preterm infants\u2014a case study and review of the literature","volume":"13","author":"Gover","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"102266","DOI":"10.1016\/j.rpth.2023.102266","article-title":"Intracardiac thrombi in pediatrics: anticoagulation approach and treatment outcomes","volume":"7","author":"Agarwal","year":"2023","journal-title":"Res Pract Thromb Haemost"},{"key":"B4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.clp.2025.02.009","article-title":"A clinical review of perinatal stroke","volume":"52","author":"Srivastava","year":"2025","journal-title":"Clin Perinatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"E158","DOI":"10.1111\/chd.12115","article-title":"Neonatal acute myocardial infarction of unknown etiology treated with surgical thrombectomy","volume":"9","author":"Ramlogan","year":"2014","journal-title":"Congenit Heart Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/S1569-9293(03)00209-3","article-title":"Successful thrombectomy of the superior vena cava thrombosis in a newborn after cardiopulmonary bypass surgery","volume":"2","author":"Dittrich","year":"2003","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1017\/S1047951112000212","article-title":"Aortic arch thrombectomy in a 2.8 kilogram neonate - 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