{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:13:02Z","timestamp":1785906782590,"version":"3.56.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the predictive value of preoperative platelet-to-white blood cell ratio (PWR) for postoperative outcomes in patients with acute type A aortic dissection (ATAAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-center retrospective cohort study, 363 ATAAD patients undergoing emergency type II hybrid aortic arch repair between January 2021 and February 2024 were stratified by median PWR into low PWR (&amp;lt;13.259) and high PWR (\u226513.259) groups. Clinical variables, operative details, and outcomes were collected. Primary outcome was in-hospital postoperative adverse events (PAEs) incidence; secondary outcomes included short- and mid-term mortality. Associations were analyzed using multivariable logistic regression and Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A considerably higher incidence of PAEs was observed in the low PWR (&amp;lt;13.259) relative to the high PWR (41.99% vs. 21.43%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) groups. Moreover, patients with low PWR showed increased in-hospital (13.81% vs. 3.30%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), 90-day (14.36% vs. 4.40%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), and 1-year (16.38% vs. 5.56%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) mortalities. Multivariable logistic regression detected low preoperative PWR as a distinct marker of PAEs. The areas under the curve for PWR in estimating PAEs was 0.705 (95% CI, 0.649\u20130.760). Cox regression analysis confirmed a significant association between low PWR and elevated short- and mid-term mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative low PWR independently predicts postoperative complications and mortality in ATAAD patients, serving as an accessible and cost-effective biomarker for risk stratification and clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2025.1669151","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:18:20Z","timestamp":1767676700000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Platelet-to-white blood cell ratio as a predictor of postoperative outcomes in acute type A aortic dissection: a single-center retrospective 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