{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:30:28Z","timestamp":1764916228663,"version":"3.46.0"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>The Taussig-Bing anomaly is a rare form of double outlet right ventricle (DORV) characterized by complex physiology, often requiring multiple surgeries. This report describes the use of the VenusP-Valve System ina 36-year-old patient with Taussig-Bing anomaly, transposition of the great arteries (TGA), and prior surgical interventions including Blalock\u2013Taussig shunt, arterial switch, and ventricular septal defect (VSD) closure. The patient presented with atrial fibrillation, baseline clinical signs of right-sided heart failure (jugular venous distension, edema, holosystolic murmur), New York Heart Association (NYHA) III symptoms, severe tricuspid regurgitation (TR), residual VSD, and significant pulmonary stenosis. Right-heart catheterization revealed an extremely high baseline Qp\/Qs of 10.4, derived by the Fick method with oxygen consumption estimation and mixed venous sampling; this value was interpreted as artifact-influenced, and normalized to \u223c2 after medical optimization. After multidisciplinary discussion, a transcatheter pulmonary valve replacement (TPVR) using the VenusP-Valve System was successfully performed. At 30 days, the patient improved to NYHA II with no major complications, reduction of TR to moderate, and stable residual VSD shunt (Qp\/Qs \u223c2). This case highlights the feasibility and clinical utility of VenusP-Valve in managing complex congenital heart disease, particularly in enlarged, irregular, patch-augmented right ventricular outflow tracts (RVOTs) not suitable for balloon-expandable or hourglass-anchoring valves.<\/jats:p>","DOI":"10.3389\/fcvm.2025.1672008","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:25:08Z","timestamp":1764915908000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcatheter pulmonary valve replacement with the venusP-valve system in a patient with double outlet right ventricle and transposition of the great arteries a first-in-human case report"],"prefix":"10.3389","volume":"12","author":[{"given":"Federica","family":"Gramegna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Saccocci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Buzzatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Faggi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eustachio","family":"Agricola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ottavio","family":"Alfieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Chessa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Maisano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/0002-9149(65)90732-0","article-title":"The anatomy of common aorticopulmonary trunk (truncus arteriosus communis) and its embryologic implications. A study of 57 necropsy cases","volume":"16","author":"Van Praagh","year":"1965","journal-title":"Am J Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1053\/pcsu.2001.24649","article-title":"Late results of the rastelli operation for transposition of the great arteries","volume":"4","author":"Dearani","year":"2001","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"key":"B3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.amjcard.2022.12.010","article-title":"Congenital pulmonic valve dysfunction treated with SAPIEN 3 transcatheter heart valve (from the COMPASSION S3 trial)","volume":"190","author":"Lim","year":"2023","journal-title":"Am J Cardiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1016\/j.jcin.2018.06.001","article-title":"3-Year Outcomes of the edwards SAPIEN transcatheter heart valve for conduit failure in the pulmonary position from the COMPASSION multicenter clinical trial","volume":"11","author":"Kenny","year":"2018","journal-title":"JACC Cardiovasc Interv"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1016\/j.jcin.2024.07.036","article-title":"Multicenter pivotal study of the alterra adaptive prestent for the treatment of pulmonary regurgitation","volume":"17","author":"Dimas","year":"2024","journal-title":"JACC Cardiovasc Interv"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.jcin.2017.05.034","article-title":"Harmony feasibility trial: acute and short-term outcomes with a self-expanding transcatheter pulmonary valve","volume":"10","author":"Bergersen","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e010852","DOI":"10.1161\/CIRCINTERVENTIONS.121.010852","article-title":"Long-Term outcomes after melody transcatheter pulmonary valve replacement in the US investigational device exemption trial","volume":"15","author":"Jones","year":"2022","journal-title":"Circ Cardiovasc Interv"},{"key":"B8","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/ccd.30916","article-title":"Five-year follow-up after percutaneous pulmonary valve implantation using the Venus P-valve system for patients with pulmonary regurgitation and an enlarged native right ventricular outflow tract","volume":"103","author":"Jin","year":"2024","journal-title":"Catheter Cardiovasc Interv"},{"key":"B9","doi-asserted-by":"publisher","first-page":"100452","DOI":"10.1016\/j.jscai.2022.100452","article-title":"Transcatheter pulmonary valve replacement: a review of current valve technologies","volume":"1","author":"Patel","year":"2022","journal-title":"J Soc Cardiovasc Angiogr Interv"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2040622319857635","DOI":"10.1177\/2040622319857635","article-title":"Percutaneous pulmonary valve implantation in patients with right ventricular outflow tract dysfunction: a systematic review and meta-analysis","volume":"10","author":"Ran","year":"2019","journal-title":"Ther Adv Chronic Dis"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1672008\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:25:08Z","timestamp":1764915908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1672008\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":10,"alternative-id":["10.3389\/fcvm.2025.1672008"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2025.1672008","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,5]]},"article-number":"1672008"}}