{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:29:43Z","timestamp":1787509783254,"version":"build-2736575974"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardioprotection is an important aspect of preventive medicine. Quercetin, a plant-derived flavonoid with antioxidant and anti-inflammatory properties, has been linked to reduced cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the cardioprotective effects of quercetin in rats with traumatic cardiac injury (TCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty-two Wistar Albino rats were randomly divided into six groups: control (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20097); TCI only (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099); TCI\u2009+\u2009DMSO (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096); and TCI\u2009+\u2009quercetin at 10, 20, or 40\u2005mg\/kg (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099 each). Quercetin or DMSO was given intraperitoneally at 0.5, 12, and 24\u2005h after trauma. Cardiac trauma was induced by dropping a standardized weight on the chest. Serum biochemical parameters (GPx, SOD, IL-1, IL-33, sST2, MDA) were measured by ELISA, and histopathological damage was scored semiquantitatively. Data were analyzed using ANOVA or Kruskal\u2013Wallis tests with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05 as significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GPx elevation was detected only at 10 and 20\u2005mg\/kg (vs. TCI;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05); 40\u2005mg\/kg was non-significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;gt;\u20090.05). Overall, IL-1 differed among groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), with no pairwise comparisons significant after correction (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;gt;\u20090.05). For IL-33, an overall group effect was observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025), while adjusted pairwise tests did not show a consistent between-group pattern (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;gt;\u20090.05). In contrast, malondialdehyde (MDA) levels were significantly reduced, particularly at the highest dose of 40\u2005mg\/kg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). Superoxide dismutase (SOD) and soluble suppression of tumorigenicity-2 (sST2) levels showed no significant differences among groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;gt;\u20090.05). Histopathological evaluation demonstrated that quercetin mitigated myocardial degeneration, inflammatory infiltration, edema, vascular congestion, hemorrhage, and necrosis in a dose-dependent manner, with the most pronounced protective effects observed at 40\u2005mg\/kg (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Quercetin, especially at 40\u2005mg\/kg, may help prevent secondary cardiac injury after trauma by reducing oxidative stress and limiting histopathological damage. These results support quercetin's cardioprotective potential and warrant confirmation in larger preclinical models with broader designs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2025.1683944","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:27:26Z","timestamp":1762324046000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of the effect of quercetin on experimental traumatic cardiac injury in rats"],"prefix":"10.3389","volume":"12","author":[{"given":"Muhammed Enes","family":"Taysi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa 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