{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:30:41Z","timestamp":1764052241003,"version":"3.45.0"},"reference-count":128,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Due to the aging population, the prevalence of aortic stenosis continues to rise, transcatheter aortic valve replacement (TAVR) has become an important method for treating severe symptomatic aortic stenosis. Although TAVR significantly improves the survival and symptoms of patients with aortic stenosis, this population is generally characterized by advanced age, frailty, and multiple comorbidities, posing challenges to postoperative functional recovery and quality of life improvement. Cardiac rehabilitation (CR) constitutes a cornerstone of secondary prevention for cardiovascular disease (CVD), and plays a pivotal role in optimizing outcomes for patients undergoing TAVR. This review aims to discuss the mechanistic, current practical evidence, existing challenges, and future directions of CR in TAVR patients.<\/jats:p>","DOI":"10.3389\/fcvm.2025.1701764","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:27:07Z","timestamp":1764052027000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac rehabilitation for TAVR patients: mechanisms, current status, and future directions"],"prefix":"10.3389","volume":"12","author":[{"given":"Huan","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"758","DOI":"10.4081\/monaldi.2016.758","article-title":"Advances in cardiac rehabilitation: cardiac rehabilitation after transcatheter aortic valve implantation","volume":"86","author":"Eichler","year":"2016","journal-title":"Monaldi Arch Chest Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1161\/CIRCULATIONAHA.119.043391","article-title":"Global, regional, and national burden of calcific aortic valve and degenerative mitral valve diseases, 1990\u20132017","volume":"141","author":"Yadgir","year":"2020","journal-title":"Circulation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1093\/eurheartj\/ehw229","article-title":"Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the OxVALVE population cohort study","volume":"37","author":"d'Arcy","year":"2016","journal-title":"Eur Heart J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"16006","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic stenosis","volume":"2","author":"Lindman","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"B5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/s12872-021-02154-8","article-title":"Current status and etiology of valvular heart disease in China: a population-based survey","volume":"21","author":"Yang","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"B6","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1093\/eurjpc\/zwad042","article-title":"Invited editorial: professor Attila Kardos MD PhD FRCP FESC in search for a mechanism of poor outcome in patients with aortic valve sclerosis without aortic stenosis and left ventricular hypertrophy. Results of a populational observational study with normal LV geometry","volume":"30","author":"Kardos","year":"2023","journal-title":"Eur J Prev Cardiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e72","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jcin.2022.11.003","article-title":"Antithrombotic after TAVR: no treatment, No problem?","volume":"16","author":"Auffret","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"B9","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3390\/jcm10040810","article-title":"Transcatheter aortic valve implantation: the new challenges of cardiac rehabilitation","volume":"10","author":"Sperlongano","year":"2021","journal-title":"J Clin Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/j.jcin.2016.05.025","article-title":"Mitral regurgitation after transcatheter aortic valve replacement: prognosis, imaging predictors, and potential management","volume":"9","author":"Cort\u00e9s","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"B11","doi-asserted-by":"publisher","first-page":"15006","DOI":"10.1038\/s41598-025-99173-8","article-title":"Risk factors and prognosis of silent cerebral infarction after transcatheter aortic valve replacement","volume":"15","author":"Wu","year":"2025","journal-title":"Sci Rep"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.jvs.2013.03.046","article-title":"Incidence and prognosis of vascular complications after transcatheter aortic valve implantation","volume":"58","author":"Mwipatayi","year":"2013","journal-title":"J Vasc Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jacc.2005.10.002","article-title":"Cardiac rehabilitation, exercise training, and psychosocial risk factors","volume":"47","author":"Lavie","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12955-022-01994-y","article-title":"Mental and psychosocial health and health related quality of life before and after cardiac rehabilitation: a prospective cohort study with comparison to specific population norms","volume":"20","author":"Angst","year":"2022","journal-title":"Health Qual Life Outcomes"},{"key":"B15","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1161\/CIRCRESAHA.125.325705","article-title":"Benefits of cardiac rehabilitation: mechanisms to restore function and clinical impact","volume":"137","author":"Damluji","year":"2025","journal-title":"Circ Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.3390\/jcm10102125","article-title":"Inpatient cardiac rehabilitation after transcatheter aortic valve replacement is associated with improved clinical performance and quality of life","volume":"10","author":"Kleczynski","year":"2021","journal-title":"J Clin Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"114","DOI":"10.2459\/JCM.0000000000000494","article-title":"Cardiac rehabilitation after transcatheter aortic valve implantation compared to patients after valve replacement","volume":"18","author":"Tarro Genta","year":"2017","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"B18","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/14017431.2022.2095432","article-title":"Long-term effects of cardiac rehabilitation after heart valve surgery - results from the randomised CopenHeartVR trial","volume":"56","author":"Sibilitz","year":"2022","journal-title":"Scand Cardiovasc J"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e009175","DOI":"10.1161\/CIRCOUTCOMES.122.009175","article-title":"Variation in cardiac rehabilitation participation during aortic valve replacement episodes of care","volume":"15","author":"Guduguntla","year":"2022","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1001\/jamacardio.2019.4032","article-title":"Association of cardiac rehabilitation with decreased hospitalization and mortality risk after cardiac valve surgery","volume":"4","author":"Patel","year":"2019","journal-title":"JAMA Cardiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1177\/2047487320913379","article-title":"Secondary prevention through comprehensive cardiovascular rehabilitation: from knowledge to implementation. 2020 update. A position paper from the secondary prevention and rehabilitation section of the European association of preventive cardiology","volume":"28","author":"Ambrosetti","year":"2021","journal-title":"Eur J Prev Cardiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e328","DOI":"10.1161\/CIR.0000000000001289","article-title":"Core components of cardiac rehabilitation programs: 2024 update: a scientific statement from the American Heart Association and the American association of cardiovascular and pulmonary rehabilitation","volume":"150","author":"Brown","year":"2024","journal-title":"Circulation"},{"key":"B23","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1177\/2047487320924912","article-title":"Standardization and quality improvement of secondary prevention through cardiovascular rehabilitation programmes in Europe: the avenue towards EAPC accreditation programme: a position statement of the secondary prevention and rehabilitation section of the European association of preventive cardiology (EAPC)","volume":"28","author":"Abreu","year":"2021","journal-title":"Eur J Prev Cardiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/eurheartj\/ehaa605","article-title":"2020 ESC guidelines on sports cardiology and exercise in patients with cardiovascular disease","volume":"42","author":"Pelliccia","year":"2021","journal-title":"Eur Heart J"},{"key":"B25","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3969\/j.issn.1004-8812.2020.07.001","article-title":"Expert consensus on exercise rehabilitation after transcatheter aortic valve replacement","volume":"28","author":"Ge","year":"2020","journal-title":"Chin J Interv Cardiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1177\/2047487318792099","article-title":"Comparison of phase 2 cardiac rehabilitation outcomes between patients after transcatheter versus surgical aortic valve replacement","volume":"25","author":"Imran","year":"2018","journal-title":"Eur J Prev Cardiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"75","DOI":"10.5334\/gh.1458","article-title":"Cardiac rehabilitation in patients with coronary heart disease - provision, attendance, and outcomes: results from the INTERASPIRE survey from fourteen countries across six WHO regions","volume":"20","author":"Kotseva","year":"2025","journal-title":"Glob Heart"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e18773","DOI":"10.2196\/18773","article-title":"Digital health interventions for cardiac rehabilitation: systematic literature review","volume":"23","author":"Wongvibulsin","year":"2021","journal-title":"J Med Internet Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e005902","DOI":"10.1161\/CIRCOUTCOMES.119.005902","article-title":"Tracking cardiac rehabilitation participation and completion among medicare beneficiaries to inform the efforts of a national initiative","volume":"13","author":"Ritchey","year":"2020","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"B30","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3390\/geriatrics9060161","article-title":"A qualitative study of barriers and facilitators to the uptake of cardiac rehabilitation in octogenarians","volume":"9","author":"Nichol","year":"2024","journal-title":"Geriatrics (Basel, Switzerland)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.pcad.2014.02.006","article-title":"The global burden of aortic stenosis","volume":"56","author":"Thaden","year":"2014","journal-title":"Prog Cardiovasc Dis"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1016\/j.jacc.2012.02.093","article-title":"Calcific aortic stenosis: a disease of the valve and the myocardium","volume":"60","author":"Dweck","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/1532-429X-14-50","article-title":"Left ventricular remodeling and hypertrophy in patients with aortic stenosis: insights from cardiovascular magnetic resonance","volume":"14","author":"Dweck","year":"2012","journal-title":"J Cardiovasc Magn Reson"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1093\/eurheartj\/eht157","article-title":"Preserved ejection fraction can accompany low gradient severe aortic stenosis: impact of pathophysiology on diagnostic imaging","volume":"34","author":"Bartel","year":"2013","journal-title":"Eur Heart J"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1007\/s10741-023-10312-7","article-title":"Acute advanced aortic stenosis","volume":"28","author":"Avvedimento","year":"2023","journal-title":"Heart Fail Rev"},{"key":"B36","doi-asserted-by":"publisher","first-page":"100089","DOI":"10.1016\/j.shj.2022.100089","article-title":"Left ventricular systolic dysfunction in aortic stenosis: pathophysiology, diagnosis, management, and future directions","volume":"6","author":"Spilias","year":"2022","journal-title":"Structural Heart"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1056\/NEJM198211253072202","article-title":"Decreased coronary reserve: a mechanism for angina pectoris in patients with aortic stenosis and normal coronary arteries","volume":"307","author":"Marcus","year":"1982","journal-title":"N Engl J Med"},{"key":"B38","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1161\/01.CIR.78.3.573","article-title":"Demonstration of an imbalance between coronary perfusion and excessive load as a mechanism of ischemia during stress in patients with aortic stenosis","volume":"78","author":"Smucker","year":"1988","journal-title":"Circulation"},{"key":"B39","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1161\/01.CIR.80.4.769","article-title":"Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of arterial perfusion pressure","volume":"80","author":"Sullivan","year":"1989","journal-title":"Circulation"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1161\/01.CIR.98.24.2709","article-title":"Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure","volume":"98","author":"Hambrecht","year":"1998","journal-title":"Circulation"},{"key":"B41","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1253\/circj.CJ-17-0817","article-title":"Transcatheter aortic valve implantation improves cardiac sympathetic nerve activity on 123I-metaiodobenzylguanidine myocardial scintigraphy in severe aortic valve stenosis","volume":"82","author":"Sobajima","year":"2018","journal-title":"Circ J"},{"key":"B42","doi-asserted-by":"publisher","first-page":"I23","DOI":"10.1161\/01.cir.0000032919.33237.4d","article-title":"Left ventricular reverse remodeling after surgical therapy for aortic stenosis: correlation to renin-angiotensin system gene expression","volume":"106","author":"Walther","year":"2002","journal-title":"Circulation"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1161\/CIRCULATIONAHA.106.654210","article-title":"B-type natriuretic peptide in low-flow, low-gradient aortic stenosis: relationship to hemodynamics and clinical outcome: results from the multicenter truly or Pseudo-severe aortic stenosis (TOPAS) study","volume":"115","author":"Bergler-Klein","year":"2007","journal-title":"Circulation"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1093\/cvr\/cvad117","article-title":"Aortic valve calcification is promoted by interleukin-8 and restricted through antagonizing CXC motif chemokine receptor 2","volume":"119","author":"Dhayni","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1136\/hrt.2009.180661","article-title":"Short-term effects of transcatheter aortic valve implantation on neurohormonal activation, quality of life and 6-minute walk test in severe and symptomatic aortic stenosis","volume":"96","author":"Gotzmann","year":"2010","journal-title":"Heart (British Cardiac Society)"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/0735-1097(93)90231-O","article-title":"Physical training improves skeletal muscle metabolism in patients with chronic heart failure","volume":"21","author":"Adamopoulos","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ijcard.2004.08.073","article-title":"Exercise training modulates cytokines activity in coronary heart disease patients","volume":"100","author":"Goldhammer","year":"2005","journal-title":"Int J Cardiol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.jacc.2011.04.020","article-title":"The role of exercise training in heart failure","volume":"58","author":"Downing","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1195028","DOI":"10.3389\/fpsyt.2023.1195028","article-title":"The pathophysiology and management of depression in cardiac surgery patients","volume":"14","author":"Vu","year":"2023","journal-title":"Front Psychiatry"},{"key":"B50","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1177\/2047487316679527","article-title":"Multicomponent cardiac rehabilitation in patients after transcatheter aortic valve implantation: predictors of functional and psychocognitive recovery","volume":"24","author":"Eichler","year":"2017","journal-title":"Eur J Prev Cardiol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e75325","DOI":"10.2196\/75325","article-title":"The effectiveness of nurse-led multidimensional digital cardiac rehabilitation in patients with unstable angina undergoing percutaneous coronary intervention: emulated target trial","volume":"27","author":"Zhou","year":"2025","journal-title":"J Med Internet Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1253\/circj.CJ-23-0668","article-title":"Comprehensive cardiac rehabilitation following acute myocardial infarction improves clinical outcomes regardless of exercise capacity","volume":"88","author":"Hiruma","year":"2024","journal-title":"Circ J"},{"key":"B53","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/HCR.0000000000000703","article-title":"Impact of comprehensive cardiac rehabilitation in elderly patients with acute heart failure","volume":"42","author":"Yamazaki","year":"2022","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-5683.25.06885-1","article-title":"Cardiac rehabilitation in patients with atrial fibrillation","volume":"73","author":"Cersosimo","year":"2025","journal-title":"Minerva Cardiol Angiol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"jrm39974","DOI":"10.2340\/jrm.v57.39974","article-title":"Barriers and facilitators to physical activity after transcatheter aortic valve replacement: a mixed-methods study","volume":"57","author":"Shen","year":"2025","journal-title":"J Rehabil Med"},{"key":"B56","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.jcin.2019.02.049","article-title":"Habitual physical activity in older adults undergoing TAVR: insights from the FRAILTY-AVR study","volume":"12","author":"Sathananthan","year":"2019","journal-title":"JACC Cardiovasc Interv"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1136\/heartjnl-2015-308827","article-title":"Physical activity increases survival after heart valve surgery","volume":"102","author":"Lund","year":"2016","journal-title":"Heart (British Cardiac Society)"},{"key":"B58","doi-asserted-by":"publisher","first-page":"200238","DOI":"10.1016\/j.ijcrp.2024.200238","article-title":"Efficacy of exercise training-based cardiac rehabilitation programmes after transcatheter aortic valve implantation: a systematic review and meta-analysis","volume":"20","author":"Hosseinpour","year":"2024","journal-title":"Int J Cardiol Cardiovasc Risk Prev"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.3390\/nu17061082","article-title":"The role of dietary education in cardiac rehabilitation","volume":"17","author":"Popiolek-Kalisz","year":"2025","journal-title":"Nutrients"},{"key":"B60","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pcad.2015.04.003","article-title":"Benefits of the Mediterranean diet: insights from the PREDIMED study","volume":"58","author":"Mart\u00ednez-Gonz\u00e1lez","year":"2015","journal-title":"Prog Cardiovasc Dis"},{"key":"B61","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1177\/2047487318817082","article-title":"Improvement of low-density lipoprotein cholesterol target achievement rates through cardiac rehabilitation for patients after ST elevation myocardial infarction or non-ST elevation myocardial infarction in Germany: results of the PATIENT CARE registry","volume":"26","author":"Schwaab","year":"2019","journal-title":"Eur J Prev Cardiol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"279","DOI":"10.11909\/j.issn.1671-5411.2014.04.001","article-title":"Cardiac rehabilitation and mid-term follow-up after transcatheter aortic valve implantation","volume":"11","author":"Zanettini","year":"2014","journal-title":"J Geriatr Cardiolol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/eurjpc\/zwad304","article-title":"Preinterventional frailty assessment in patients scheduled for cardiac surgery or transcatheter aortic valve implantation: a consensus statement of the European association for cardio-thoracic surgery (EACTS) and the European association of preventive cardiology (EAPC) of the European Society of Cardiology (ESC)","volume":"31","author":"Niebauer","year":"2024","journal-title":"Eur J Prev Cardiol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jjcc.2018.11.013","article-title":"Prognostic value of objective nutritional status after transcatheter aortic valve replacement","volume":"73","author":"Honda","year":"2019","journal-title":"J Cardiol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e026294","DOI":"10.1161\/JAHA.122.026294","article-title":"Prevalence and prognostic significance of malnutrition in older Japanese adults at high surgical risk undergoing transcatheter aortic valve implantation","volume":"11","author":"Ishizu","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"B66","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ijcard.2018.11.097","article-title":"Nutritional risk index predicts survival in patients undergoing transcatheter aortic valve replacement","volume":"276","author":"Gonz\u00e1lez Ferreiro","year":"2019","journal-title":"Int J Cardiol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1161\/CIRCULATIONAHA.118.033887","article-title":"Malnutrition and mortality in frail and non-frail older adults undergoing aortic valve replacement","volume":"138","author":"Goldfarb","year":"2018","journal-title":"Circulation"},{"key":"B68","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00392-017-1183-1","article-title":"Nutrition and mobility predict all-cause mortality in patients 12 months after transcatheter aortic valve implantation","volume":"107","author":"Eichler","year":"2018","journal-title":"Clin Res Cardiol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e009342","DOI":"10.1161\/CIRCINTERVENTIONS.120.009342","article-title":"Prognostic impact of change in nutritional risk on mortality and heart failure after transcatheter aortic valve replacement","volume":"14","author":"Gonz\u00e1lez Ferreiro","year":"2021","journal-title":"Circ Cardiovasc Interv"},{"key":"B70","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1002\/jcsm.12689","article-title":"Frailty in patients undergoing transcatheter aortic valve replacement: prognostic value of the geriatric nutritional risk Index","volume":"12","author":"Seoudy","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"B71","doi-asserted-by":"publisher","first-page":"e037086","DOI":"10.1161\/JAHA.124.037086","article-title":"Association between the malnutrition Status and all-cause mortality in patients with moderate and severe aortic stenosis: a prospective cohort study","volume":"14","author":"Li","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"B72","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1080\/00015385.2020.1757854","article-title":"Value of prognostic nutritional index for survival prediction in trans-catheter aortic valve replacement compared to other common nutritional indexes","volume":"76","author":"Mas-Peiro","year":"2021","journal-title":"Acta Cardiol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/ajcn\/82.4.777","article-title":"Geriatric nutritional risk index: a new index for evaluating at-risk elderly medical patients","volume":"82","author":"Bouillanne","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"B74","doi-asserted-by":"publisher","first-page":"161","DOI":"10.31083\/j.rcm.2019.03.524","article-title":"Serum albumin in patients undergoing transcatheter aortic valve replacement: a meta-analysis","volume":"20","author":"Hsieh","year":"2019","journal-title":"Rev Cardiovasc Med"},{"key":"B75","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1536\/ihj.19-395","article-title":"Meta-analysis of the impact of pre-procedural Serum albumin on mortality in patients undergoing transcatheter aortic valve replacement","volume":"61","author":"Liu","year":"2020","journal-title":"Int Heart J"},{"key":"B76","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.mayocp.2021.11.022","article-title":"C-reactive protein to albumin ratio in patients undergoing transcatheter aortic valve replacement","volume":"97","author":"Seoudy","year":"2022","journal-title":"Mayo Clin Proc"},{"key":"B77","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jjcc.2019.02.017","article-title":"Evaluation of objective nutritional indexes as predictors of one-year outcomes after transcatheter aortic valve implantation","volume":"74","author":"Okuno","year":"2019","journal-title":"J Cardiol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1080\/00015385.2020.1747177","article-title":"Impact of objective nutritional indexes on 1-year mortality after transcatheter aortic valve implantation: a prospective observational cohort study","volume":"76","author":"Kucukosmanoglu","year":"2021","journal-title":"Acta Cardiol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00380-020-01659-0","article-title":"Impact of nutritional index on long-term outcomes of elderly patients with coronary artery disease: sub-analysis of the SHINANO 5 year registry","volume":"36","author":"Maruyama","year":"2021","journal-title":"Heart Vessels"},{"key":"B80","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.3390\/nu12113311","article-title":"Prognostic effect of a novel simply calculated nutritional index in acute decompensated heart failure","volume":"12","author":"Ishiwata","year":"2020","journal-title":"Nutrients"},{"key":"B81","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s00392-023-02220-5","article-title":"A simply calculated nutritional index provides clinical implications in patients undergoing transcatheter aortic valve replacement","volume":"113","author":"Sudo","year":"2024","journal-title":"Clin Res Cardiol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1001\/jama.295.6.655","article-title":"Low-fat dietary pattern and risk of cardiovascular disease: the women\u2019s health initiative randomized controlled dietary modification trial","volume":"295","author":"Howard","year":"2006","journal-title":"JAMA"},{"key":"B83","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.1161\/STROKEAHA.120.033214","article-title":"Mediterranean Diet reduces atherosclerosis progression in coronary heart disease: an analysis of the CORDIOPREV randomized controlled trial","volume":"52","author":"Jimenez-Torres","year":"2021","journal-title":"Stroke"},{"key":"B84","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ijcard.2020.08.007","article-title":"Impact of cognitive behavioral therapy on depression symptoms after transcatheter aortic valve replacement: a randomized controlled trial","volume":"321","author":"Edwards","year":"2020","journal-title":"Int J Cardiol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.genhosppsych.2023.11.009","article-title":"Mental health and transcatheter aortic valve replacement: a scoping systematic review","volume":"86","author":"Suen","year":"2024","journal-title":"Gen Hosp Psychiatry"},{"key":"B86","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1001\/jamacardio.2017.5065","article-title":"Is depression an important new mortality risk factor after aortic valve replacement or simply a component of the geriatric disease spectrum?","volume":"3","author":"Patel","year":"2018","journal-title":"JAMA Cardiology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e012875","DOI":"10.1161\/CIRCINTERVENTIONS.123.012875","article-title":"Association of depression and cognitive dysfunction with patient-centered outcomes after transcatheter aortic valve replacement","volume":"16","author":"El-Sabawi","year":"2023","journal-title":"Circ Cardiovasc Interv"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1136\/heartjnl-2016-309414","article-title":"Cardiac rehabilitation increases physical capacity but not mental health after heart valve surgery: a randomised clinical trial","volume":"102","author":"Sibilitz","year":"2016","journal-title":"Heart (British Cardiac Society)"},{"key":"B89","doi-asserted-by":"publisher","first-page":"e024377","DOI":"10.1161\/JAHA.121.024377","article-title":"Anxiety and depression following aortic valve replacement","volume":"11","author":"Wegermann","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"B90","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1177\/2047487318765258","article-title":"Exercise intervention after transcatheter aortic valve implantation: current evidence and issues to be resolved","volume":"25","author":"Hansen","year":"2018","journal-title":"Eur J Prev Cardiol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3109\/14659891.2013.765515","article-title":"The association of tobacco use and gender to cardiac rehabilitation outcomes: a preliminary investigation","volume":"19","author":"Weinberger","year":"2014","journal-title":"J Subst Use"},{"key":"B92","doi-asserted-by":"publisher","first-page":"2497","DOI":"10.1161\/01.CIR.101.21.2497","article-title":"New insights into the progression of aortic stenosis: implications for secondary prevention","volume":"101","author":"Palta","year":"2000","journal-title":"Circulation"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.jacc.2017.01.025","article-title":"Association between cardiovascular risk factors and aortic stenosis: the CANHEART aortic stenosis study","volume":"69","author":"Yan","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/S0022-5223(02)73619-2","article-title":"Risk factors for atherosclerosis and the degeneration of pericardial valves after aortic valve replacement","volume":"126","author":"Nollert","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B95","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur Heart J"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2025.0716","article-title":"Optimal evaluation and treatment of cardiac rehabilitation for patients following TAVR: a personalized program based on the five prescriptions","volume":"15","author":"Han","year":"2025","journal-title":"Aging Dis"},{"key":"B97","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jacc.2013.02.088","article-title":"Evaluation and management of paravalvular aortic regurgitation after transcatheter aortic valve replacement","volume":"62","author":"Sinning","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"B98","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1016\/j.jacc.2014.08.052","article-title":"Incidence, predictors, and prognostic impact of late bleeding complications after transcatheter aortic valve replacement","volume":"64","author":"G\u00e9n\u00e9reux","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1016\/j.jacc.2018.08.2172","article-title":"Stroke after surgical versus transfemoral transcatheter aortic valve replacement in the PARTNER trial","volume":"72","author":"Kapadia","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.jcin.2010.09.009","article-title":"Renal function as predictor of mortality in patients after percutaneous transcatheter aortic valve implantation","volume":"3","author":"Sinning","year":"2010","journal-title":"JACC Cardiovasc Interv"},{"key":"B101","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.jacc.2022.11.028","article-title":"Infective endocarditis after transcatheter aortic valve replacement: JACC state-of-the-art review","volume":"81","author":"Del Val","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1161\/CIRCULATIONAHA.117.028352","article-title":"Conduction disturbances after transcatheter aortic valve replacement: current Status and future perspectives","volume":"136","author":"Auffret","year":"2017","journal-title":"Circulation"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s40520-018-1088-5","article-title":"The influence of age on the psychological profile of patients with cardiac implantable electronic devices: results from the Italian population in a multicenter study conducted by the European heart rhythm association","volume":"31","author":"Fumagalli","year":"2018","journal-title":"Aging Clin Exp Res"},{"key":"B104","doi-asserted-by":"publisher","first-page":"4543","DOI":"10.3390\/jcm12134543","article-title":"Long-Term outcomes of transvenous lead extraction: a comparison in patients with or without infection from the Italian region with the oldest population","volume":"12","author":"Barca","year":"2023","journal-title":"J Clin Med"},{"key":"B105","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jacc.2017.06.024","article-title":"Frailty in older adults undergoing aortic valve replacement: the FRAILTY-AVR study","volume":"70","author":"Afilalo","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1093\/eurjpc\/zwae239","article-title":"Cardiac rehabilitation and frailty: a systematic review and meta-analysis","volume":"31","author":"MacEachern","year":"2024","journal-title":"Eur J Prev Cardiol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"e040459","DOI":"10.1136\/bmjopen-2020-040459","article-title":"Measurement and prognosis of frail patients undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis","volume":"11","author":"Li","year":"2021","journal-title":"BMJ Open"},{"key":"B108","doi-asserted-by":"publisher","first-page":"e008566","DOI":"10.1161\/CIRCOUTCOMES.121.008566","article-title":"Role of frailty in identifying benefit from transcatheter versus surgical aortic valve replacement","volume":"14","author":"Strom","year":"2021","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"B109","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1161\/CIRCULATIONAHA.116.025630","article-title":"Impact of the clinical frailty scale on outcomes after transcatheter aortic valve replacement","volume":"135","author":"Shimura","year":"2017","journal-title":"Circulation"},{"key":"B110","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1053\/j.jvca.2019.01.023","article-title":"Cardiac prehabilitation","volume":"33","author":"McCann","year":"2019","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"B111","doi-asserted-by":"publisher","first-page":"e081164","DOI":"10.1136\/bmj-2024-081164","article-title":"Relative efficacy of prehabilitation interventions and their components: systematic review with network and component network meta-analyses of randomised controlled trials","volume":"388","author":"McIsaac","year":"2025","journal-title":"BMJ (Clinical Research ed.)"},{"key":"B112","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1161\/CIR.0000000000001150","article-title":"Digital technologies in cardiac rehabilitation: a science advisory from the American Heart Association","volume":"148","author":"Golbus","year":"2023","journal-title":"Circulation"},{"key":"B113","doi-asserted-by":"publisher","first-page":"767","DOI":"10.26599\/1671-5411.2023.11.003","article-title":"Exercise-based real-time telerehabilitation for older patients recently discharged after transcatheter aortic valve implantation: an extended feasibility study","volume":"20","author":"Brocki","year":"2023","journal-title":"J Geriatr Cardiol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"e45247","DOI":"10.2196\/45247","article-title":"Efficacy and safety of home-based cardiac telemonitoring rehabilitation in patients after transcatheter aortic valve implantation: single-center usability and feasibility study","volume":"10","author":"Ashikaga","year":"2023","journal-title":"JMIR Rehabilitation and Assistive Technologies"},{"key":"B115","doi-asserted-by":"publisher","first-page":"e20072","DOI":"10.2196\/20072","article-title":"Using wearable devices to monitor physical activity in patients undergoing aortic valve replacement: protocol for a prospective observational study","volume":"9","author":"Lorenzoni","year":"2020","journal-title":"JMIR Res Protoc"},{"key":"B116","doi-asserted-by":"publisher","first-page":"3347","DOI":"10.3390\/s23063347","article-title":"Wearable activity trackers objectively measure incidental physical activity in older adults undergoing aortic valve replacement","volume":"23","author":"Straiton","year":"2023","journal-title":"Sensors (Basel, Switzerland)"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1136\/heartjnl-2015-308966","article-title":"Telehealth exercise-based cardiac rehabilitation: a systematic review and meta-analysis","volume":"102","author":"Rawstorn","year":"2016","journal-title":"Heart (British Cardiac Society)"},{"key":"B118","doi-asserted-by":"publisher","first-page":"102087","DOI":"10.1016\/j.jacadv.2025.102087","article-title":"Outcomes of telemedicine TAVR preoperative evaluations","volume":"4","author":"Tobia","year":"2025","journal-title":"JACC. Advances"},{"key":"B119","doi-asserted-by":"publisher","first-page":"e007741","DOI":"10.1161\/CIRCOUTCOMES.121.007741","article-title":"Digital health intervention in acute myocardial infarction","volume":"14","author":"Marvel","year":"2021","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"B120","doi-asserted-by":"publisher","first-page":"e030654","DOI":"10.1161\/JAHA.123.030654","article-title":"Rationale and design of the mTECH-rehab randomized controlled trial: impact of a Mobile technology enabled corrie cardiac rehabilitation program on functional Status and cardiovascular health","volume":"13","author":"Isakadze","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"B121","doi-asserted-by":"publisher","first-page":"e70848","DOI":"10.2196\/70848","article-title":"Effectiveness of smartwatch device on adherence to home-based cardiac rehabilitation in patients with coronary heart disease: randomized controlled trial","volume":"13","author":"Zhang","year":"2025","journal-title":"JMIR Mhealth Uhealth"},{"key":"B122","doi-asserted-by":"publisher","first-page":"e63797","DOI":"10.2196\/63797","article-title":"Wearable devices in remote cardiac rehabilitation with and without weekly online coaching for patients with coronary artery disease: randomized controlled trial","volume":"13","author":"Nishio","year":"2025","journal-title":"JMIR Mhealth Uhealth"},{"key":"B123","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/HCR.0000000000000912","article-title":"Effect of exercise-based cardiac rehabilitation on patients with chronic heart failure after transcatheter aortic valve replacement: a randomized controlled trial","volume":"45","author":"Song","year":"2025","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"B124","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/eurjpc\/zwac269","article-title":"Inspiratory muscle training improves cardiopulmonary function in patients after transcatheter aortic valve replacement: a randomized clinical trial","volume":"30","author":"Xu","year":"2023","journal-title":"Eur J Prev Cardiol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1016\/j.jamda.2023.04.025","article-title":"Efficacy and safety of moderate-intensity continuous training on the improvement of cardiopulmonary function in patients after transcatheter aortic valve replacement (ENERGY): a randomized controlled trial","volume":"24","author":"Hu","year":"2023","journal-title":"J Am Med Dir Assoc"},{"key":"B126","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3390\/jcdd10080343","article-title":"The effects of exercise training on exercise capacity and vascular function after transcatheter aortic valve implantation-A pilot study","volume":"10","author":"Vitez","year":"2023","journal-title":"J Cardiovasc Dev Dis"},{"key":"B127","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/ehjdh\/ztab007","article-title":"Effect of a pragmatic home-based mobile health exercise intervention after transcatheter aortic valve replacement: a randomized pilot trial","volume":"2","author":"Lindman","year":"2021","journal-title":"European Heart Journal. Digital Health"},{"key":"B128","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12877-020-01964-3","article-title":"The impact of additional resistance and balance training in exercise-based cardiac rehabilitation in older patients after valve surgery or intervention: randomized control trial","volume":"21","author":"Tamulevi\u010di\u016bt\u0117-Prascien\u0117","year":"2021","journal-title":"BMC Geriatr"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1701764\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:27:12Z","timestamp":1764052032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1701764\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":128,"alternative-id":["10.3389\/fcvm.2025.1701764"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2025.1701764","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"article-number":"1701764"}}