{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:42:09Z","timestamp":1767681729378,"version":"3.48.0"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Unilateral pulmonary artery agenesis is a rare congenital malformation, typically observed in infancy or childhood, but rarely in adulthood. An elderly female patient admitted to our hospital with a chief complaint of acute chest pain is reported here. The patient experienced a sudden onset of chest pain during physical exertion (folding quilts) 4 days before admission, which progressively worsened. Thoracoabdominal computed tomography angiography (CTA) was performed to rule out acute aortic syndromes, revealing agenesis of the right pulmonary artery with systemic collateral circulation supplying the right lung. A further examination of the clinical history and symptoms uncovered a past medical history of chronic pulmonary disease lasting several decades. The patient's clinical manifestations had consistently presented as symptoms of common conditions such as chronic bronchitis, bronchiectasis, pneumonia, and pulmonary tuberculosis, and a definitive diagnosis of Isolated Unilateral Pulmonary Artery Agenesis (IUAPA) had not been established, nor had the association between this disorder and chronic pulmonary lesions been previously considered. Although follow-up examinations confirmed that the present episode of chest pain resulted from an osteoporotic vertebral fracture, further in-depth research is necessary to fully understand the relationship between the absence of the pulmonary artery and the chronic pulmonary lesions. This report, together with the literature review, discusses the key characteristics, misdiagnosis challenges, and strategies for improving the diagnosis of IUAPA.<\/jats:p>","DOI":"10.3389\/fcvm.2025.1708458","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:37:36Z","timestamp":1767681456000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Congenital isolated unilateral pulmonary artery agenesis: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Weijun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1378\/chest.122.4.1471","article-title":"Isolated unilateral absence of a pulmonary artery: a case report and review of the literature","volume":"122","author":"Ten Harkel","year":"2002","journal-title":"Chest"},{"key":"B2","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1378\/chest.108.3.670","article-title":"The varied manifestation of pulmonary artery agenesis in adulthood","volume":"108","author":"Bouros","year":"1995","journal-title":"Chest"},{"key":"B3","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3760\/cma.j.issn.1004-4477.2019.07.007","article-title":"Prenatal echocardiographic diagnosis of unilateral absence of pulmonary artery","volume":"28","author":"Li","year":"2019","journal-title":"Chin J Ultrason"},{"key":"B4","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3969\/j.issn.1002-0101.2021.06.009","article-title":"Analysis of clinical and ultrasonographic features of unilateral absence of pulmonary artery","volume":"37","author":"Tian","year":"2021","journal-title":"Chin J Ultrason Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3969\/j.issn.1009-6663.2022.03.033","article-title":"Isolated unilateral absence of pulmonary artery in an adult: a case report and literature review","volume":"27","author":"Hu","year":"2022","journal-title":"J Clin Pulmonary Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"E06314","DOI":"10.3760\/cma.j.cmcr.2022.e06314","article-title":"One case of congenital right pulmonary artery deficiency","volume":"4","author":"Hao","year":"2022","journal-title":"Chin Med Case Repository"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e008587","DOI":"10.1161\/JAHA.118.008587","article-title":"Definition and management of segmental pulmonary hypertension","volume":"7","author":"Dimopoulos","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"B8","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3760\/cma.j.issn.1673-436X.2012.005.009","article-title":"Isolated absence of the left pulmonary artery: a case report and literature review","volume":"32","author":"Li","year":"2012","journal-title":"Int J Respiratory Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3969\/j.issn.1007-5062.2013.03.019","article-title":"Imaging diagnosis of congenital unilateral absence of pulmonary artery: 25 cases","volume":"32","author":"Zhang","year":"2013","journal-title":"J Cardiovasc Pulmonary Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.3760\/cma.j.issn.1673-4777.2017.07.011","article-title":"Analysis of clinical characteristics in patients with isolated unilateral absence of pulmonary artery","volume":"12","author":"Wang","year":"2017","journal-title":"Chin Med"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1708458\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:37:42Z","timestamp":1767681462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1708458\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":10,"alternative-id":["10.3389\/fcvm.2025.1708458"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2025.1708458","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"article-number":"1708458"}}