{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:47:24Z","timestamp":1767682044152,"version":"3.48.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to compare echocardiographic outcomes and analyze the changes in ventricular remodeling at different time points after surgery in patients with severe aortic stenosis (AS) undergoing either surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study consecutively enrolled 175 patients with severe AS who underwent either SAVR or TAVR. Transthoracic echocardiograms obtained at baseline, 30 days, and 1 year after the procedure were analyzed by multiple echocardiographers at our institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, the TAVR group was significantly older (74\u2009\u00b1\u20097 years vs. 62\u2009\u00b1\u20099 years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) and had a higher prevalence of hypertension (53.5% vs. 31.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), coronary artery disease (38.4% vs. 23.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028), and atrial fibrillation (16.3% vs. 2.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Additionally, the TAVR cohort demonstrated significantly worse cardiac functional status (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Compared to TAVR patients, SAVR patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200987) exhibited a more pronounced reduction in left ventricular end-systolic dimension (\u22120.5\u2009\u00b1\u20090.65\u2005cm vs. \u22120.2\u2009\u00b1\u20090.47\u2005cm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) and left ventricular end-diastolic dimension (\u22120.6\u2009\u00b1\u20090.64\u2005cm vs. \u22120.3\u2009\u00b1\u20090.55\u2005cm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) at the 1-month follow-up. A decrease in left ventricular mass was observed in both groups from baseline to 1 month postoperatively, with the SAVR group showing a significantly greater reduction (LV mass: \u221267.3\u2009\u00b1\u200959.31\u2005g vs. \u221238.2\u2009\u00b1\u200946.49\u2005g,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003; LVMI: \u221239.1\u2009\u00b1\u200933.93\u2005g\/m\n                      <jats:sup>2<\/jats:sup>\n                      vs. \u221222.5\u2009\u00b1\u200927.08\u2005g\/m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005). However, these differences were not sustained at the 1-year follow-up. SAVR patients experienced a transient decline in right ventricular function at 1 month, which recovered by 1 year postoperatively. At the 1-year follow-up, the TAVR group experienced a higher incidence of Major Adverse Cardiac Events (MACE) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), despite showing significant improvement in the severity of both mitral and tricuspid regurgitation compared to baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Although pulmonary artery pressure improved in both groups after AVR, the SAVR group demonstrated significantly lower pressure at 1 year (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with severe aortic stenosis, SAVR was associated with more significant regression of left ventricular dimensions and mass at 1 month compared to TAVR, alongside a transient impairment of right ventricular function. By 1 year postoperatively, however, no significant differences in ventricular remodeling were observed between the two groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2025.1712400","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:43:48Z","timestamp":1767681828000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative study of transcatheter aortic valve implantation versus conventional surgical aortic valve replacement in the treatment of severe aortic stenosis with reverse ventricular remodeling"],"prefix":"10.3389","volume":"12","author":[{"given":"Haoyan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.hfc.2006.09.010","article-title":"The epidemiology of valvular heart disease: a growing public health problem","volume":"2","author":"Supino","year":"2006","journal-title":"Heart Fail Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S0140-6736(09)60211-7","article-title":"Aortic stenosis","volume":"373","author":"Carabello","year":"2009","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","article-title":"Transcatheter versus surgical aortic-valve replacement in high-risk patients","volume":"364","author":"Smith","year":"2011","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or surgical aortic-valve replacement in intermediate-risk patients","volume":"374","author":"Leon","year":"2016","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"Mack","year":"2019","journal-title":"N Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1056\/NEJMoa1400590","article-title":"Transcatheter aortic-valve replacement with a self-expanding prosthesis","volume":"370","author":"Adams","year":"2014","journal-title":"N Engl J Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.jcmg.2019.02.034","article-title":"Multimodality imaging markers of adverse myocardial remodeling in aortic stenosis","volume":"12","author":"Treibel","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1407566","DOI":"10.3389\/fcvm.2024.1407566","article-title":"Reverse left ventricular remodeling after aortic valve replacement for aortic stenosis: a systematic review and meta-analysis","volume":"11","author":"Sousa Nunes","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1161\/CIRCULATIONAHA.119.044574","article-title":"Echocardiographic results of transcatheter versus surgical aortic valve replacement in low-risk patients: the PARTNER 3 trial","volume":"141","author":"Pibarot","year":"2020","journal-title":"Circulation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e003426","DOI":"10.1161\/CIRCINTERVENTIONS.115.003426","article-title":"Self-expanding transcatheter aortic valve replacement versus surgical valve replacement in patients at high risk for surgery: a study of echocardiographic change and risk prediction","volume":"9","author":"Little","year":"2016","journal-title":"Circ Cardiovasc Interv"},{"key":"B11","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1161\/01.cir.72.4.810","article-title":"Noninvasive estimation of valve area in patients with aortic stenosis by Doppler ultrasound and two-dimensional echocardiography","volume":"72","author":"Skjaerpe","year":"1985","journal-title":"Circulation"},{"key":"B12","first-page":"I280","article-title":"Two-dimensional echocardiographic determination of left ventricular volume, systolic function, and mass. 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