{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T06:42:15Z","timestamp":1765953735060,"version":"3.48.0"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>A 49-year-old woman with a congenital quadricuspid aortic valve presented in cardiogenic shock due to severe aortic regurgitation. She underwent transfemoral transcatheter aortic valve replacement with a 29\u2005mm self-expanding prosthesis. The procedure was technically successful with minimal paravalvular leak and significant symptomatic improvement. However, her long-term course was complicated by medication nonadherence, valve thrombosis, thromboembolic coronary events, and progressive heart failure. This case highlights the anatomical and technical challenges of transcatheter valve therapy in non-tricuspid anatomy, including annular sizing and valve anchoring without calcification, and underscores the critical importance of post-procedural anticoagulation adherence and meticulous follow-up to prevent thrombotic complications.<\/jats:p>","DOI":"10.3389\/fcvm.2025.1716669","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T06:37:33Z","timestamp":1765953453000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcatheter aortic valve replacement for severe aortic regurgitation in quadricuspid aortic valve: a case report"],"prefix":"10.3389","volume":"12","author":[{"given":"Abdullah","family":"Aljudaibi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Sonbol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haytham","family":"Allaham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1161\/CIRCULATIONAHA.115.017743","article-title":"Quadricuspid aortic valve: characteristics, associated structural cardiovascular abnormalities, and clinical outcomes","volume":"133","author":"Tsang","year":"2016","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.14740\/cr1308","article-title":"Quadricuspid aortic valve: an Introduction for clinicians","volume":"13","author":"Saith","year":"2022","journal-title":"Cardiol Res"},{"key":"B3","doi-asserted-by":"publisher","first-page":"7815279","DOI":"10.1155\/crp\/7815279","article-title":"Transcatheter aortic valve replacement in patients with quadricuspid aortic valve: a case series and systematic review","volume":"2025","author":"Sheng","year":"2025","journal-title":"Cardiol Res Pract"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1011466","DOI":"10.3389\/fcvm.2022.1011466","article-title":"Transcatheter aortic valve replacement in patients with quadricuspid aortic valve in a single center","volume":"9","author":"Liu","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"qyad032","DOI":"10.1093\/ehjimp\/qyad032","article-title":"Transcatheter aortic valve replacement in quadricuspid aortic valve: the crucial role of three-dimensional simulation in risk assessment","volume":"1","author":"Oba","year":"2023","journal-title":"Eur Heart J Imaging Methods Pract"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.1016\/j.jcin.2021.01.014","article-title":"TAVR In a patient with quadricuspid aortic stenosis: the role of patient-specific computer simulation in treatment\u202fplanning and outcome prediction","volume":"14","author":"Han","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e39536","DOI":"10.7759\/cureus.39536","article-title":"Quadricuspid aortic valve: an incidental finding in an elderly man","volume":"15","author":"Khatun","year":"2023","journal-title":"Cureus"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1716669\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T06:37:39Z","timestamp":1765953459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1716669\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":7,"alternative-id":["10.3389\/fcvm.2025.1716669"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2025.1716669","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]},"article-number":"1716669"}}