{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:28:42Z","timestamp":1767677322694,"version":"3.48.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["C2025110003"],"award-info":[{"award-number":["C2025110003"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015285","name":"Hebei Province Medical Science Research Key Project","doi-asserted-by":"publisher","award":["20261184"],"award-info":[{"award-number":["20261184"]}],"id":[{"id":"10.13039\/501100015285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The majority of myocardial infarction (MI) cases occur due to plaque rupture in the context of atherosclerosis (AS). This study aimed to elucidate the mechanisms underlying the effect of\n                      <jats:italic>Helianthus Annuus<\/jats:italic>\n                      L. (HAL) on MI in the setting of AS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Apolipoprotein E-deficient mice were divided into four groups of 11. Mice in the Control and MI groups were fed a normal diet for 24-weeks, while mice in the AS\u2009+\u2009MI group were fed a high-fat diet (HFD) and mice in the AS\u2009+\u2009MI\u2009+\u2009HAL group were fed HFD supplemented with 5% HAL powder. After 23 weeks, the mice in the MI, AS\u2009+\u2009MI and AS\u2009+\u2009MI\u2009+\u2009HAL groups underwent coronary artery ligation to induce MI. A week post-ligation, 6 surviving mice were randomly selected from each group for the subsequent experiments, echocardiography was performed, followed by analysis of aortic plaque and myocardial tissue to explore potential mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HAL intervention attenuated cardiac remodeling and dysfunction induced by MI, reduced inflammatory cell infiltration and fibrosis in the myocardium, and consequently improved cardiac function. HAL alleviated the inflammatory response by reducing serum concentrations and myocardial expression of interleukin-1\u03b2, interleukin-6 and tumor necrosis factor-\u03b1. Furthermore, Western blotting analysis demonstrated that HAL reduced nuclear factor-\u03baB (NF-\u03baB) expression. HAL also enhanced superoxide dismutase and glutathione peroxidase levels while suppressing malondialdehyde and myeloperoxidase levels in cardiac infarction tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data indicated that HAL attenuates cardiac remodeling by inhibiting inflammation and reducing oxidative stress. These findings provide novel insights into the effects and mechanisms of HAL in the context of MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2025.1744283","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:18:06Z","timestamp":1767676686000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Helianthus Annuus L. ameliorates atherosclerosis-induced myocardial infarction via inhibiting inflammation and oxidative stress"],"prefix":"10.3389","volume":"12","author":[{"given":"Mengjue","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenqing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoran","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1038\/s41591-023-02513-2","article-title":"A new clinical classification of acute myocardial infarction","volume":"29","author":"Lindahl","year":"2023","journal-title":"Nat Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":":233","DOI":"10.1016\/j.pcad.2020.02.009","article-title":"Role of endothelial dysfunction in determining angina after percutaneous coronary intervention: learning from pathophysiology to optimize treatment","volume":"63","author":"Mangiacapra","year":"2020","journal-title":"Prog Cardiovasc Dis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S0140-6736(21)00249-X","article-title":"Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II): a prospective natural history study","volume":"397","author":"Erlinge","year":"2021","journal-title":"Lancet (London, England)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1111\/dom.14829","article-title":"Interconnection between cardiovascular, renal and metabolic disorders: a narrative review with a focus on Japan","volume":"24","author":"Kadowaki","year":"2022","journal-title":"Diabetes Obes Metab"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1161\/CIRCULATIONAHA.123.065390","article-title":"Piezo1-Mediated neurogenic inflammatory cascade exacerbates ventricular remodeling after myocardial infarction","volume":"149","author":"Sun","year":"2024","journal-title":"Circulation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.jacbts.2023.05.010","article-title":"Extracellular matrix protein-1 as a mediator of inflammation-induced fibrosis after myocardial infarction","volume":"8","author":"Hardy","year":"2023","journal-title":"JACC Basic Transl Sci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"114597","DOI":"10.1016\/j.bcp.2021.114597","article-title":"Pharmacological inhibition of GLUT1 as a new immunotherapeutic approach after myocardial infarction","volume":"190","author":"Chen","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41420-022-01235-7","article-title":"Inflammation in myocardial infarction: roles of mesenchymal stem cells and their secretome","volume":"8","author":"Shao","year":"2022","journal-title":"Cell Death Discov"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1002\/bab.2194","article-title":"Nuciferine from nelumbo nucifera gaertn. 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