{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:11:20Z","timestamp":1777511480149,"version":"3.51.4"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Severe aortic stenosis (AS) management increasingly requires multidisciplinary coordination across diagnostic, interventional, and rehabilitation stages. Integrated care pathways (ICPs) supported by structured data systems may improve safety and outcomes, but real-world evidence in AS remains limited. We aimed to characterize a contemporary cohort of patients with severe AS managed within an ICP at a tertiary hospital, comparing profiles and outcomes by treatment strategy, and to describe diagnostic procedures and the implementation of cardiac rehabilitation (CR) interventions embedded in the pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study of all consecutive patients with AS evaluated by a multidisciplinary heart team between 2018 and 2022. Baseline characteristics and frailty, diagnostic tests, CR interventions, procedural details, and outcomes were collected via an interoperable data management platform and compared across treatment groups: surgical (SAVR) or transcatheter (TAVR) valve replacement, or conservative management. Early survival was assessed using Kaplan\u2013Meier analysis with log-rank testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 984 patients (median age 78 years, 42% women), 43.9% underwent SAVR, 49.8% TAVR, and 6.3% were managed conservatively. TAVR and conservative groups were older, frailer, and had higher comorbidity. Device success at 30 days was high (\u224891%), with periprocedural death at 2.5% for interventions, vs. 9.7% early mortality for conservative management (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Early survival differed significantly (log-rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). TAVR had higher permanent pacemaker implantation (21.7% vs. 7.4% for SAVR,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) and major vascular complications (4.1% vs. 0.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), while SAVR had more reoperations (8.3% vs. 0.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) and atrial fibrillation (18.9% vs. 10.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Prehabilitation was implemented in 64.6% of candidates, while postprocedural CR remained underutilized (11.3%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Integrated care for a cohort of patients with AS, supported by structured data management, enabled comprehensive profiling, systematic outcome monitoring, and identification of improvement areas. Both SAVR and TAVR achieved high success with low early mortality, while conservative management had poor survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2025.1745204","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:16:16Z","timestamp":1768569376000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Implementation of an integrated care pathway for severe aortic stenosis: a prospective cohort study of clinical profiles, safety, and outcomes"],"prefix":"10.3389","volume":"12","author":[{"given":"Violeta","family":"Gonz\u00e1lez-Salvado","sequence":"first","affiliation":[{"name":"Cardiology Department, University Clinical Hospital of Santiago de Compostela","place":["Santiago de Compostela, Spain"]},{"name":"Health Research Institute of Santiago de Compostela (IDIS)","place":["Santiago de Compostela, Spain"]},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Sestayo Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Health Research Institute of Santiago de Compostela (IDIS)","place":["Santiago de Compostela, Spain"]},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Alonso-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Health Research Institute of Santiago de Compostela (IDIS)","place":["Santiago de Compostela, Spain"]},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"de la Fuente-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Clinical Hospital of Santiago de Compostela","place":["Santiago de Compostela, Spain"]},{"name":"Health Research Institute of Santiago de Compostela (IDIS)","place":["Santiago de Compostela, Spain"]},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana Maria","family":"Laranjeira Correia","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Cardiologia, Unidade Local de Sa\u00fade T\u00e2mega e Sousa","place":["Guilhufe, Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ux\u00eda","family":"Lens-Bravo","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Clinical Hospital of Santiago de Compostela","place":["Santiago de Compostela, Spain"]},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1nxel","family":"Ruzo-Cedillo","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Clinical Hospital of Santiago de Compostela","place":["Santiago de Compostela, Spain"]},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibiana","family":"Villamayor-Blanco","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, University Clinical Hospital of Santiago de Compostela","place":["Santiago de Compostela, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Gonz\u00e1lez-Juanatey","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Clinical Hospital of Santiago de Compostela","place":["Santiago de Compostela, Spain"]},{"name":"Health Research Institute of Santiago de Compostela (IDIS)","place":["Santiago de Compostela, Spain"]},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Pe\u00f1a-Gil","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Clinical Hospital of Santiago de Compostela","place":["Santiago de Compostela, Spain"]},{"name":"Health Research Institute of Santiago de Compostela (IDIS)","place":["Santiago de Compostela, Spain"]},{"name":"Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III (ISCIII)","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/s41569-021-00570-z","article-title":"Global epidemiology of valvular heart disease","volume":"18","author":"Coffey","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1161\/CIRCULATIONAHA.119.041080","article-title":"Contemporary presentation and management of valvular heart disease: the EUrobservational research programme valvular heart disease II survey","volume":"140","author":"Iung","year":"2019","journal-title":"Circulation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","article-title":"Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study","volume":"62","author":"Osnabrugge","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1093\/eurheartj\/ehad887","article-title":"Severe aortic stenosis: secular trends of incidence and outcomes","volume":"45","author":"Benfari","year":"2024","journal-title":"Eur Heart J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1016\/j.jacc.2023.09.796","article-title":"The mortality burden of untreated aortic stenosis","volume":"82","author":"G\u00e9n\u00e9reux","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"E72","DOI":"10.1161\/CIR.0000000000000923","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"B7","doi-asserted-by":"publisher","first-page":"ezaf276","DOI":"10.1093\/eurheartj\/ehaf194","article-title":"2025 ESC\/EACTS guidelines for the management of valvular heart disease: developed by the task force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European association for cardio-thoracic surgery (EACTS)","volume":"67","author":"Praz","year":"2025","journal-title":"Eur Heart J"},{"key":"B8","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1186\/s12913-022-07960-0","article-title":"Definition and conceptualization of the patient-centered care pathway, a proposed integrative framework for consensus: a concept analysis and systematic review","volume":"22","author":"Gartner","year":"2022","journal-title":"BMC Health Serv Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1186\/S12913-022-08625-8","article-title":"Development and operationalization of a data framework to assess quality of integrated diabetes care in the fragmented data landscape of Belgium","volume":"22","author":"Veerle","year":"2022","journal-title":"BMC Health Serv Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1093\/jamia\/ocab039","article-title":"Clinical data sharing improves quality measurement and patient safety","volume":"28","author":"D\u2019amore","year":"2021","journal-title":"J Am Med Inform Assoc"},{"key":"B11","doi-asserted-by":"publisher","first-page":"E009297","DOI":"10.1161\/CIRCINTERVENTIONS.120.009297","article-title":"Increasing wait-time mortality for severe aortic stenosis: a population-level study of the transition in practice from surgical aortic valve replacement to transcatheter aortic valve replacement","volume":"13","author":"Albassam","year":"2020","journal-title":"Circ Cardiovasc Interv"},{"key":"B12","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.rec.2018.03.023","article-title":"Prognosis of patients with severe aortic stenosis after the decision to perform an intervention","volume":"72","author":"Gonz\u00e1lez Saldivar","year":"2019","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"B13","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1093\/ehjci\/jew335","article-title":"Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European association of cardiovascular imaging and the American society of echocardiography","volume":"18","author":"Baumgartner","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging classification of aortic stenosis based on the extent of cardiac damage","volume":"38","author":"G\u00e9n\u00e9reux","year":"2017","journal-title":"Eur Heart J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1093\/eurheartj\/ehaa799","article-title":"Valve academic research consortium 3: updated endpoint definitions for aortic valve clinical research","volume":"42","author":"G\u00e9n\u00e9reux","year":"2021","journal-title":"Eur Heart J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.medcli.2023.06.025","article-title":"Impact of SARS-CoV-2 infection in patients with cardiac amyloidosis: results of a multicentre registry","volume":"161","author":"Larra\u00f1aga-Moreira","year":"2023","journal-title":"Med Clin (Barc)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1002\/ehf2.13964","article-title":"Impact of SARS-cov-2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry","volume":"9","author":"Gimeno","year":"2022","journal-title":"ESC Heart Fail"},{"key":"B18","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.repc.2016.11.015","article-title":"Advantages of a prospective multidisciplinary approach in transcatheter aortic valve implantation: eight years of experience","volume":"36","author":"Costa","year":"2017","journal-title":"Rev Port Cardiol"},{"key":"B19","year":""},{"key":"B20","year":""},{"key":"B21","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1093\/eurheartj\/ehab773","article-title":"Trends in aortic valve replacement for aortic stenosis: a French nationwide study","volume":"43","author":"Nguyen","year":"2022","journal-title":"Eur Heart J"},{"key":"B22","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.amjcard.2023.11.024","article-title":"Temporal trends in patient characteristics and outcomes of transcatheter aortic valve implantation and surgical aortic valve replacement: a nationwide study","volume":"211","author":"Lundahl","year":"2024","journal-title":"Am J Cardiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1253\/circj.CJ-21-1062","article-title":"Rationale, design, and baseline characteristics of the CURRENT AS registry-2","volume":"86","author":"Takeji","year":"2022","journal-title":"Circ J"},{"key":"B24","doi-asserted-by":"publisher","first-page":"36657","DOI":"10.1161\/JAHA.124.036657","article-title":"Clinical outcomes according to aortic stenosis management: insights from real-world practice","volume":"13","author":"Coisne","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"B25","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/eurjpc\/zwad304","article-title":"Preinterventional frailty assessment in patients scheduled for cardiac surgery or transcatheter aortic valve implantation: a consensus statement of the European association for cardio-thoracic surgery (EACTS) and the European association of preventive cardiology (EAPC) of the European Society of Cardiology (ESC)","volume":"31","author":"Niebauer","year":"2024","journal-title":"Eur J Prev Cardiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1253\/circj.CJ-19-0247","article-title":"Reasons for choosing conservative management in symptomatic patients with severe aortic stenosis\u2014observations from the CURRENT AS registry","volume":"83","author":"Ishii","year":"2019","journal-title":"Circ J"},{"key":"B27","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.jcin.2024.09.044","article-title":"Low-Gradient severe aortic stenosis: insights from the CURRENT AS registry-2","volume":"18","author":"Taniguchi","year":"2025","journal-title":"JACC Cardiovasc Interv"},{"key":"B28","doi-asserted-by":"publisher","first-page":"100959","DOI":"10.1016\/j.jacadv.2024.100959","article-title":"Cardiac damage staging predicts outcomes in aortic valve stenosis after aortic valve replacement: meta-analysis","volume":"3","author":"Abdelfattah","year":"2024","journal-title":"JACC Adv"},{"key":"B29","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.jcmg.2022.10.009","article-title":"Aortic stenosis progression: a systematic review and meta-analysis","volume":"16","author":"Willner","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"key":"B30","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.echo.2020.11.015","article-title":"Excess mortality associated with progression rate in asymptomatic aortic valve stenosis","volume":"34","author":"Benfari","year":"2021","journal-title":"J Am Soc Echocardiogr"},{"key":"B31","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.amjcard.2023.07.148","article-title":"Outcomes of patients with very severe aortic stenosis treated with transcatheter aortic valve implantation","volume":"205","author":"Angelillis","year":"2023","journal-title":"Am J Cardiol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e001681","DOI":"10.1136\/openhrt-2021-001681","article-title":"Impact of COVID-19 on the imaging diagnosis of cardiac disease in Europe","volume":"8","author":"Williams","year":"2021","journal-title":"Open Heart"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.rec.2021.10.008","article-title":"Spanish Cardiac catheterization and coronary intervention registry. 30th official report of the interventional cardiology association of the Spanish society of cardiology (1990\u20132020) in the year of the COVID-19 pandemic","volume":"74","author":"Romaguera","year":"2021","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"B34","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s12471-023-01795-y","article-title":"Changing haemodynamic status of patients referred for transcatheter aortic valve intervention during the COVID-19 pandemic","volume":"31","author":"Ooms","year":"2023","journal-title":"Neth Heart J"},{"key":"B35","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/ehjci\/jeae263","article-title":"Echocardiographic phenotype in severe aortic stenosis with and without transthyretin cardiac amyloidosis: the AMY-TAVI study","volume":"26","author":"Bastos-Fernandez","year":"2025","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"B36","doi-asserted-by":"publisher","first-page":"200238","DOI":"10.1016\/j.ijcrp.2024.200238","article-title":"Efficacy of exercise training-based cardiac rehabilitation programmes after transcatheter aortic valve implantation: a systematic review and meta-analysis","volume":"20","author":"Hosseinpour","year":"2024","journal-title":"Int J Cardiol Cardiovasc Risk Prev"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1001\/jamacardio.2019.4032","article-title":"Association of cardiac rehabilitation with decreased hospitalization and mortality risk after cardiac valve surgery","volume":"4","author":"Patel","year":"2019","journal-title":"JAMA Cardiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"100581","DOI":"10.1016\/j.jacadv.2023.100581","article-title":"Predictors and variation in cardiac rehabilitation participation after transcatheter aortic valve replacement","volume":"2","author":"Sukul","year":"2023","journal-title":"JACC Adv"},{"key":"B39","doi-asserted-by":"publisher","first-page":"E009175","DOI":"10.1161\/CIRCOUTCOMES.122.009175","article-title":"Variation in cardiac rehabilitation participation during aortic valve replacement episodes of care","volume":"15","author":"Guduguntla","year":"2022","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"B40","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/eurjpc\/zwaa104","article-title":"Offering, participation and adherence to cardiac rehabilitation programmes in the elderly: a European comparison based on the EU-CaRE multicentre observational study","volume":"28","author":"Gonz\u00e1lez-Salvado","year":"2021","journal-title":"Eur J Prev Cardiol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jacc.2025.05.021","article-title":"Outcomes in older patients undergoing surgical aortic valve replacement with concomitant procedures","volume":"86","author":"Kundi","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.ahj.2025.07.001","article-title":"Incremental cost of complications after TAVR and SAVR in contemporary clinical practice","volume":"290","author":"Harvey","year":"2025","journal-title":"Am Heart J"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1016\/j.jcin.2024.07.032","article-title":"Conduction disturbances after transcatheter aortic valve replacement: an update on epidemiology, preventive strategies, and management","volume":"17","author":"Nuche","year":"2024","journal-title":"JACC Cardiovasc Interv"},{"key":"B44","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.amjcard.2025.05.009","article-title":"Comparative prognostic value of risk factors for predicting pacemaker implantation after transcatheter aortic valve replacement: a systematic review and network meta-analysis","volume":"250","author":"Hosseini Mohammadi","year":"2025","journal-title":"Am J Cardiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1056\/NEJMoa1700456","article-title":"Surgical or transcatheter aortic-valve replacement in intermediate-risk patients","volume":"376","author":"Reardon","year":"2017","journal-title":"N Engl J Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients","volume":"380","author":"Popma","year":"2019","journal-title":"N Engl J Med"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.jcin.2023.05.020","article-title":"Incidence, predictors, and prognostic impact of new permanent pacemaker implantation after TAVR with self-expanding valves","volume":"16","author":"Pagnesi","year":"2023","journal-title":"JACC Cardiovasc Interv"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.jcin.2025.03.028","article-title":"Long-Term outcomes of patients requiring pacemaker implantation after transcatheter aortic valve replacement: the SwissTAVI registry","volume":"18","author":"Badertscher","year":"2025","journal-title":"JACC Cardiovasc Interv"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients","volume":"380","author":"Mack","year":"2019","journal-title":"N Engl J Med"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or surgical aortic-valve replacement in intermediate-risk patients","volume":"374","author":"Leon","year":"2016","journal-title":"N Engl J Med"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1093\/eurheartj\/ehs255","article-title":"Updated standardized endpoint definitions for transcatheter aortic valve implantation: the valve academic research consortium-2 consensus document","volume":"33","author":"Kappetein","year":"2012","journal-title":"Eur Heart J"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.cjca.2025.03.034","article-title":"Vascular complications in patients undergoing transcatheter aortic valve replacement with contemporary devices","volume":"41","author":"Cepas-Guill\u00e9n","year":"2025","journal-title":"Can J Cardiol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1093\/eurheartj\/ehad019","article-title":"Postoperative atrial fibrillation: from mechanisms to treatment","volume":"44","author":"Gaudino","year":"2023","journal-title":"Eur Heart J"},{"key":"B54","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.jcin.2022.01.018","article-title":"New-Onset atrial fibrillation after transcatheter aortic valve replacement: a systematic review and meta-analysis","volume":"15","author":"Ryan","year":"2022","journal-title":"JACC Cardiovasc Interv"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1745204\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:16:17Z","timestamp":1768569377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1745204\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,16]]},"references-count":54,"alternative-id":["10.3389\/fcvm.2025.1745204"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2025.1745204","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,16]]},"article-number":"1745204"}}