{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:14:30Z","timestamp":1769534070467,"version":"3.49.0"},"reference-count":4,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myocardial infarction is the most common cause of pathological Q waves on electrocardiogram (ECG), but other conditions that cause myocardial injury or abnormal conduction (such as cardiomyopathy, myocarditis, cardiac tumors or amyloidosis, WPW, etc.) can also produce pathological Q waves. Whether myocardial calcification can lead to pathological Q waves remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A 24-year-old man with a solitary kidney and multiple childhood abdominal surgeries had been on maintenance hemodialysis since 2017 (three times weekly), with a dialysis vintage of approximately 8 years. He was admitted for left upper-limb swelling of 2 months\u2019 duration. On admission his temperature was 36.6\u00b0C, blood pressure 93\/75\u2005mmHg, and heart rate 95\u2005bpm. ECG showed complete left bundle branch block (cLBBB) and pathological Q waves in leads I, aVL, V5 and V6, without significant ST-T elevation. Transthoracic echocardiography(TTE) revealed global cardiac enlargement with marked systolic and diastolic dysfunction (LVEF\u2009\u2248\u200922%, LVEDD 80\u2005mm), and an irregular hyperechoic mass at the cardiac apex measuring approximately 3.0\u2009\u00d7\u20094.0\u2005cm. Contrast chest CT confirmed focal calcifications in the high lateral wall and a hemispherical calcified lesion at the apex. Laboratory tests showed severe renal impairment (serum creatinine 827\u2005\u00b5mol\/L), markedly elevated NT-proBNP (32,961\u2005pg\/ml), mildly elevated troponin I (0.216\u2005ng\/ml) and myoglobin &amp;gt;1,000\u2005ng\/ml. Prior records documented severe disturbances of mineral metabolism: serum calcium 1.88\u2005mmol\/L, serum phosphorus 3.27\u2005mmol\/L, 25-OH vitamin D 13.05\u2005ng\/ml, and iPTH up to 2,000\u2005pg\/ml.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management and outcome<\/jats:title>\n                    <jats:p>The patient underwent diagnostic evaluation, vascular access revision, and continued dialysis; his symptoms improved and he was discharged. He continues regular outpatient hemodialysis and is under follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We report a rare case of focal myocardial calcification with pathological Q waves in a maintenance dialysis patient. Chronic kidney disease (CKD)-related disturbances of calcium\u2013phosphate metabolism can cause metastatic myocardial calcification. Severe focal calcification may produce mechanical compression and cell necrosis, disrupt electrical coupling, create electrically silent zones, and result in pathological Q waves. In CKD patients with abnormal ECG findings, myocardial calcification should be included in the differential diagnosis and evaluated using imaging and metabolic data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2025.1745357","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:19:05Z","timestamp":1769411945000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A case of myocardial calcification combined with abnormal Q waves on electrocardiogram"],"prefix":"10.3389","volume":"12","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Electrocardiogram, Jiangmen Central Hospital","place":["Jiangmen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qixiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Electrocardiogram, Jiangmen Central Hospital","place":["Jiangmen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxian","family":"Situ","sequence":"additional","affiliation":[{"name":"Department of Electrocardiogram, Jiangmen Central Hospital","place":["Jiangmen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jiangmen Central Hospital","place":["Jiangmen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Jiangmen Central Hospital","place":["Jiangmen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"103498","DOI":"10.1016\/j.jaccas.2025.103498","article-title":"Incidental discovery of dystrophic myocardial calcification","volume":"30","author":"Ramos-C\u00e1zares","year":"2025","journal-title":"JACC Case Rep"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e591","DOI":"10.1016\/j.amjmed.2020.02.045","article-title":"Myocardial calcifications: thinking beyond the heart","volume":"133","author":"Hoang","year":"2020","journal-title":"Am J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e67226","DOI":"10.7759\/cureus.67226","article-title":"An intriguing case of myocardial deposits","volume":"16","author":"Pawa","year":"2024","journal-title":"Cureus"},{"key":"B4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1159\/000495946","article-title":"Utility of cardiac biomarkers in the setting of kidney disease","volume":"141","author":"Savoj","year":"2019","journal-title":"Nephron"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1745357\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:19:27Z","timestamp":1769411967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1745357\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":4,"alternative-id":["10.3389\/fcvm.2025.1745357"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2025.1745357","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]},"article-number":"1745357"}}