{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T12:25:19Z","timestamp":1771935919790,"version":"3.50.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>\n                    Few studies have explored the relationship between the creatinine-to-body weight ratio (Cre\/BW) and arterial stiffness. Consequently, this research aimed to investigate the association in the Chinese population. This investigation used data from the Asymptomatic Polyvascular Abnormalities Community (APAC) study, where brachial-ankle pulse wave velocity (baPWV) was measured. After a 2-year follow-up period, 1,651 individuals participated in the longitudinal analysis, among whom 464 people had baPWV \u22651,400\u2005cm\/s. Multivariable-adjusted logistic regression was employed to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of arterial stiffness. The findings from both the cross-sectional and longitudinal analyses were largely in agreement, with the fully adjusted ORs in the highest tertile of the Cre\/BW ratio being 1.36 (95% CI, 1.21\u20131.64) and 2.09 (95% CI, 1.52\u20132.87), respectively. Restricted cubic splines (RCS) analyses revealed a J-shaped associated in both cross-sectional and longitudinal studies. Subgroup analysis showed that the associations were stronger in participants younger than 60 years (1.40; 95% CI, 1.15\u20131.71,\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>int<\/jats:sub>\n                    \u2009=\u20090.0481). In the cross-sectional analysis, the optimal cutoff value of the Cre\/BW ratio to predict arterial stiffness was 1.25, while in the longitudinal analysis, it was 1.29, with corresponding Youden indices of 6.7% and 11%. The study suggested that the Cre\/BW ratio was positively associated with the risk of arterial stiffness in Chinese adults.\n                  <\/jats:p>","DOI":"10.3389\/fcvm.2026.1640962","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:31:56Z","timestamp":1771399916000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between creatinine-to-body weight ratio and arterial stiffness: a cross-sectional and longitudinal study in the Chinese population"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuan","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, China"]},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, 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and Clinical Trial, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, China"]},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, China"]},{"name":"Department of Epidemiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University","place":["Beijing, China"]},{"name":"Department of Clinical Epidemiology and Clinical Trial, Capital Medical University","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenhao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Statistics-Mathematics, Rutgers University\u2013New Brunswick","place":["New-Brunswick, NJ, United 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