{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:46:18Z","timestamp":1782279978768,"version":"3.54.5"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recurrent cerebral embolism due to direct cardiac invasion by lung cancer is exceedingly rare yet clinically significant, representing a convergence of neuro-oncologic and cardiogenic stroke mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>A 41-year-old woman presented with acute right-sided hemiparesis and aphasia. Imaging revealed left middle cerebral artery occlusion, treated successfully with mechanical thrombectomy. Four days later, she developed a second embolic stroke in the right middle cerebral artery (MCA) territory\u2014again resolved via thrombectomy. Further evaluation uncovered a right lung adenocarcinoma infiltrating the pericardium, pulmonary vein, and left atrium. The patient received systemic chemotherapy and anticoagulation. No subsequent embolic events occurred during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case demonstrates a rare but important cause of recurrent cerebral embolism\u2014direct cardiac invasion by malignancy\u2014and highlights the efficacy of thrombectomy in cancer-associated large-vessel occlusion. Clinicians should maintain high suspicion for tumor-related stroke in atypical embolic presentations, especially in younger individuals without conventional risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1688578","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:46:58Z","timestamp":1782276418000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Recurrent cerebral embolism secondary to direct cardiac invasion by lung adenocarcinoma"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiangxiong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Shunde Hospital of Jinan University","place":["Foshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenwen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Shunde Hospital of Jinan University","place":["Foshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayao","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Shunde Hospital of Jinan University","place":["Foshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Shunde Hospital of Jinan University","place":["Foshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Shunde Hospital of Jinan University","place":["Foshan, China"]},{"name":"Department of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3208","DOI":"10.1161\/STROKEAHA.114.006536","article-title":"Secular trends in ischemic stroke subtypes and stroke risk factors","volume":"45","author":"Bogiatzi","year":"2014","journal-title":"Stroke"},{"key":"B2","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1161\/CIRCRESAHA.116.308407","article-title":"Cardioembolic 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