{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:12:02Z","timestamp":1787026322206,"version":"build-2736575974"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014125","name":"Fujian Provincial Health Commission","doi-asserted-by":"publisher","award":["2024CXA007"],"award-info":[{"award-number":["2024CXA007"]}],"id":[{"id":"10.13039\/501100014125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017954","name":"Fujian Provincial Finance Department","doi-asserted-by":"publisher","award":["2023248"],"award-info":[{"award-number":["2023248"]}],"id":[{"id":"10.13039\/100017954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lipoprotein(a) [Lp(a)] is a well-established independent risk factor for cardiovascular disease. However, the long-term effects of Lp(a) on coronary plaque phenotype remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the potential association between Lp(a) levels and coronary plaque volume, composition, and progression using coronary computed tomography angiography (CCTA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with available data for Lp(a) and underwent baseline CCTA examinations between January 2009 to December 2015 and subsequently underwent a follow-up coronary CTA were retrospectively enrolled. Quantitative CCTA analyses measured plaque length, total plaque volume and composition volume. Patients were categorized into an elevated Lp(a) group (\u226530\u2005mg\/dL) and a normal Lp(a) group (&amp;lt;30\u2005mg\/dL). The association between Lp(a) and baseline plaque characteristic and progression were investigated in linear mixed-effects models adjusted for clinical factors. Subgroup analyses were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 453 patients (mean age 64.7 years, 77.7% male) with a median follow-up of 6.15 years. elevated Lp(a) was linked to higher baseline plaque burden (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) and accelerated LAP volume progression (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.55\u2005mm\n                      <jats:sup>3<\/jats:sup>\n                      \/year, 95% CI: 0.04\u20131.06;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036) after adjusting for confounders. In addition, patients with diabetes, female gender, family history of CAD, or aged &amp;lt;60 years and with normal lipid profiles showed higher progression in total plaque volume and LAP, fibro-fatty, and fibrous components. Increased calcification volume progression was also seen in those with diabetes, female gender, smoking, drinking, or normal LDL-C levels. The association between Lp(a) and calcification progression was more pronounced in statin users.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated Lp (a) level was associated with high coronary artery plaque burden at baseline and rapid progression of LAP at follow-up. Lp(a) may serve as a significant residual risk factor in seemingly \u201clow-risk\u201d populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1699503","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:46:03Z","timestamp":1770273963000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lipoprotein(a) and plaque progression: insights from serial coronary computed tomography angiography and quantitative plaque assessment"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaofang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital","place":["Fuzhou, Fujian, 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