{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:45:56Z","timestamp":1782708356617,"version":"3.54.5"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thoracic aortic diseases (TAD) require complex surgical and longitudinal follow-up care. Evidence on health-related quality of life (HRQoL) and psychological distress in real-world TAD outpatient cohorts remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe longitudinal trajectories of HRQoL and psychological distress in patients with TAD and to examine associations with key demographic and clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 111 patients (256 visits, 2023\u20132025). Primary outcomes were EQ-5D-5L index values, EQ-VAS scores, and PHQ-4 total scores. Linear mixed-effects models (random intercepts for patient ID) and logistic regression (PHQ-4 \u22656) were used to account for repeated measures. Primary predictors included sex, surgical status, and time since surgery; age and visit number were examined exploratorily.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median EQ-5D-5L was 0.71 (IQR 0.55\u20130.88), EQ-VAS 70 (60\u201380), and PHQ-4 3 (1\u20135). Time since surgery predicted HRQoL improvement (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009&amp;gt;\u20090,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Preoperative patients showed lower HRQoL (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009&amp;lt;\u20090,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.01) and twice the odds of clinically relevant distress (OR 2.0, 95% CI 1.2\u20133.3). Female sex showed nonsignificant trends toward lower HRQoL and higher distress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative TAD patients reported lower HRQoL and higher distress, while postoperative recovery was associated with gradual improvement. Findings reflect real-world patterns in a mixed pre-\/postoperative outpatient cohort and support integrating brief psychosocial screening into routine TAD follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1715132","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T04:26:01Z","timestamp":1782707161000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Anxiety, depression and health-related quality of life in patients with thoracic aortic disease: a longitudinal study in a cardiothoracic outpatient clinic"],"prefix":"10.3389","volume":"13","author":[{"given":"Ismail","family":"Dalyanoglu","sequence":"first","affiliation":[{"name":"Department for Vascular and Endovascular Surgery, Sankt Marien-Hospital Buer GmbH","place":["Gelsenkirchen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Markser","sequence":"additional","affiliation":[{"name":"Clinical Institute for Psychosomatic Medicine and Psychotherapy, University Hospital Duesseldorf","place":["Duesseldorf, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Nienhaus","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University Hospital Duesseldorf","place":["Duesseldorf, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esma","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Duesseldorf","place":["Duesseldorf, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Morjan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Duesseldorf","place":["Duesseldorf, 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