{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:14:03Z","timestamp":1778649243664,"version":"3.51.4"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"\n Background and aims<\/jats:title>\n \n The revised CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n -VA score facilitates stroke risk assessment in patients with atrial fibrillation. This study investigates the value of the CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n -VA for prediction of all-cause and cardiovascular mortality and ventricular arrhythmia (VA) in patients with ischemic heart disease (IHD) and dilated cardiomyopathy (DCM) undergoing implantable cardioverter-defibrillator (ICD) therapy.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We analyzed data from 1,626 ICD recipients with IHD (\n n<\/jats:italic>\n \u2009=\u20091,225) or DCM (\n n<\/jats:italic>\n \u2009=\u2009401) enrolled in a prospective registry at University Hospital Basel. Patients were stratified into low and high CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n -VA groups based on median score within each condition. Mortality and VA outcomes were assessed using Kaplan\u2013Meier survival analysis and Cox proportional hazards models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The median CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n -VA was 3 overall, 2 in DCM, and 4 in IHD patients. During a median follow-up of 7.5 years, 46% died, with an all-cause mortality rate of 6.1 per 100 patient-years. Higher CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n -VA scores were associated with increased all-cause and cardiovascular mortality in both IHD (HR 2.36, 95% CI 1.99\u20132.80,\n p<\/jats:italic>\n \u2009&lt;\u20090.001 for all-cause death) and DCM (HR 1.98, 95% CI 1.44\u20132.73,\n p<\/jats:italic>\n \u2009&lt;\u20090.001 for all-cause death). Each one-point increase in CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n -VA increased mortality risk (HR 1.4, 95% CI 1.34\u20131.47,\n p<\/jats:italic>\n \u2009&lt;\u20090.001 for all-cause death). No association was observed between CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n -VA and VA occurrence in the overall cohort or subgroups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n -VA is strongly associated with all-cause and cardiovascular mortality in ICD patients with IHD and DCM, but does not predict VA. Thus, it may aid in mortality risk stratification but should not be used as a primary tool for arrhythmic risk assessment.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1743535","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:47:40Z","timestamp":1778647660000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["CHA2DS2-VA score for predicting ventricular arrhythmias and mortality in ICD patients with ischemic heart disease and dilated cardiomyopathy: results from a prospective cohort"],"prefix":"10.3389","volume":"13","author":[{"given":"Benjamin","family":"V\u00f6geli","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University Basel","place":["Basel, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Badertscher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University Basel","place":["Basel, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Schaerli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University Basel","place":["Basel, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Sticherling","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University Basel","place":["Basel, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University Basel","place":["Basel, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University Basel","place":["Basel, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Krisai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University Basel","place":["Basel, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"Sch\u00e4r","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University Basel","place":["Basel, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC guidelines for the management of atrial fibrillation developed in collaboration with the European association for cardio-thoracic surgery (EACTS)","volume":"45","author":"Van 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