{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T21:26:49Z","timestamp":1785706009812,"version":"3.56.0"},"reference-count":226,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Myocardial infarction (MI), a critical condition within the spectrum of cardiovascular diseases, is a leading cause of mortality and morbidity globally. This review focuses on the role of mitochondrial dysfunction in MI, covering fundamental theories, epidemiology, diagnostic approaches, therapeutic strategies, current debates, and future research directions. It explores the development of concepts, underlying pathophysiological mechanisms, and the impact of mitochondrial genetics on MI. The review addresses epidemiological factors, including prevalence, demographic disparities, and associated risk factors. Furthermore, it provides a comprehensive analysis of diagnostic methodologies, encompassing biomarkers, imaging techniques, and molecular diagnostics. The discourse expands to include therapeutic strategies, incorporating pharmacological interventions, gene therapy, and lifestyle modifications. It provides a critical analysis of the controversies regarding the causative role of mitochondrial dysfunction, the challenges in translating research findings into clinical practice, and the associated ethical considerations. 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