{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:47:35Z","timestamp":1776919655370,"version":"3.51.2"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Recurrent myocarditis is commonly associated with infectious or immune etiologies. This case suggests a potential association between a\n                      <jats:italic>DSP<\/jats:italic>\n                      gene variant and recurrent myocarditis, highlighting a new direction for etiological investigation in such patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      We present a case of a young female admitted with chest pain and recurrent elevation of serum troponin. Cardiac magnetic resonance imaging (cMRI) revealed late gadolinium enhancement (LGE), indicating myocardial injury. No viral or other infectious causes were identified. Next-generation sequencing detected a heterozygous\n                      <jats:italic>DSP<\/jats:italic>\n                      variant (c.2297G\u2009&amp;gt;\u2009C, p.Ser766Thr), which was confirmed by Sanger sequencing. This finding suggests that the recurrent myocarditis may be associated with the identified\n                      <jats:italic>DSP<\/jats:italic>\n                      gene variant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case indicates that genetic screening should be considered in patients with recurrent myocarditis. The\n                      <jats:italic>DSP<\/jats:italic>\n                      gene should be included in relevant genetic screening panels to facilitate precise diagnosis and inform long-term management strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1750721","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:22:27Z","timestamp":1776918147000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent myocarditis in a young female with a desmoplakin gene variant: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Chenxi","family":"Liu","sequence":"first","affiliation":[{"name":"Chinese People\u2019s Liberation Army Rocket Force Characteristic Medical Center","place":["Beijing, China"]},{"name":"The Graduate Training Base of Jinzhou Medical University, Chinese People\u2019s Liberation Army Rocket Force Characteristic Medical Center","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Wen","sequence":"additional","affiliation":[{"name":"The Graduate Training Base of Jinzhou Medical University, Chinese People\u2019s Liberation Army Rocket Force Characteristic Medical Center","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyue","family":"Qu","sequence":"additional","affiliation":[{"name":"Chinese People\u2019s Liberation Army Rocket Force Characteristic Medical Center","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhitao","family":"Jin","sequence":"additional","affiliation":[{"name":"Chinese People\u2019s Liberation Army Rocket Force Characteristic Medical Center","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaojiao","family":"Xu","sequence":"additional","affiliation":[{"name":"The Graduate Training Base of Jinzhou Medical University, Chinese People\u2019s Liberation Army Rocket Force Characteristic Medical Center","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojiong","family":"Lu","sequence":"additional","affiliation":[{"name":"Chinese People\u2019s Liberation Army Rocket Force Characteristic Medical Center","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese People\u2019s Liberation Army Rocket Force Characteristic Medical Center","place":["Beijing, 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