{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:05:20Z","timestamp":1780031120899,"version":"3.53.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between the time-weighted cumulative Life's Essential 8 (TWC-LE8) score and aortic valve calcification (AVC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This analysis included 15,321 adults (mean age, 63.79 years; 76.44% men) from the Kailuan cohort who completed four health examinations between 2006 and 2012 and subsequently underwent standardized echocardiography. The TWC-LE8 score (range, 0\u2013100) was used to classify cardiovascular health (CVH) as low (&amp;lt;50), moderate (50\u201379), or high (\u226580). Multivariable logistic regression was used to estimate odds ratios (ORs) for AVC across CVH categories, and restricted cubic spline models were applied to assess the dose\u2013response relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2,894 AVC cases were identified. Compared with low CVH, moderate CVH was associated with lower odds of AVC (OR\u2009=\u20090.53, 95% CI: 0.47\u20130.61), and high CVH was associated with even lower odds of AVC (OR\u2009=\u20090.25, 95% CI: 0.15\u20130.40). A linear inverse association between TWC-LE8 score and AVC was observed (P for trend\u2009&amp;lt;\u20090.001). Age-stratified analyses showed significant heterogeneity. Among participants aged \u226555 years, high CVH was associated with 74% lower odds of AVC (OR\u2009=\u20090.26, 95% CI: 0.15\u20130.45), whereas no significant association was observed among those aged &amp;lt;55 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher cumulative LE8 scores were strongly associated with lower odds of AVC, particularly among older adults. These findings support an inverse association between long-term cardiovascular health and AVC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1763288","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:52:42Z","timestamp":1780030362000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between time-weighted cumulative life's essential 8 and aortic valve calcification"],"prefix":"10.3389","volume":"13","author":[{"given":"Man","family":"Gui","sequence":"first","affiliation":[{"name":"School of Nursing and Rehabilitation, North China University of Science and Technology","place":["Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kailuan General Hospital","place":["Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonghaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Imaging Department, Children\u2019s Hospital Affiliated to Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Nursing and Rehabilitation, North China University of Science and Technology","place":["Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Huo","sequence":"additional","affiliation":[{"name":"School of Public Health, North China University of Science and Technology","place":["Tangshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nursing, North China University of Science and Technology Affiliated Hospital","place":["Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nursing, North China University of Science and Technology Affiliated Hospital","place":["Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[{"name":"School of Nursing and Rehabilitation, North China University of Science and Technology","place":["Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Clinical, North China University of Science and Technology","place":["Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Spine and Spinal Cord, Affiliated Hospital of North China University of Science and Technology","place":["Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Public Health Clinical Center, Shandong University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kailuan General Hospital","place":["Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Xing","sequence":"additional","affiliation":[{"name":"School of Clinical, North China University of Science and Technology","place":["Tangshan, Hebei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e037991","DOI":"10.1161\/JAHA.124.037991","article-title":"Global, regional, and national burden of valvular heart disease, 1990 to 2021","volume":"13","author":"Chen","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1093\/eurheartj\/ehab316","article-title":"Dusp26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells","volume":"42","author":"Wang","year":"2021","journal-title":"Eur Heart J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1161\/CIRCULATIONAHA.110.006767","article-title":"Calcific aortic valve disease: not simply a degenerative process: a review and agenda for research from the national heart and lung and blood institute aortic stenosis working group. 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