{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:34:03Z","timestamp":1773815643367,"version":"3.50.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The WiSE-CRT system offers an innovative approach to biventricular pacing in individuals who previously were considered too high risk or had failed traditional transvenous CRT therapy. The impact on LV volumes and systolic function have previously been published. This study evaluates the impact of the WiSE CRT system on diastolic filling parameters and mitral regurgitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study of patients in SOLVE-CRT with device implantation, activated CRT therapy, and a 6-month follow-up TTE. Baseline and 6-month parameters of diastolic function and mitral regurgitation were evaluation. Most patients had sufficient data for analysis. A sub-group analysis examined results in ischemic and non-ischemic cardiomyopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Individual parameters of diastolic function and mitral regurgitation trended towards improvement at 6-months. Summative classification of diastolic function and mitral regurgitation both showed statistically significant improvement at 6-months follow-up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In addition to the established improvement in LV volumes and LV EF, patients with the WiSE-CRT biventricular pacing system demonstrate improvement in aggregate assessment of diastolic function and mitral regurgitation at 6-months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1768362","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:38:32Z","timestamp":1773812312000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of cardiac resynchronization therapy on diastolic parameters and mitral regurgitation: echocardiographic analysis of ultrasound-based left ventricular endocardial pacing system"],"prefix":"10.3389","volume":"13","author":[{"given":"Ryan","family":"Wilson","sequence":"first","affiliation":[{"name":"Penn State College of Medicine","place":["Hershey, PA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"NCH Healthcare System","place":["Naples, Florida"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"James","sequence":"additional","affiliation":[{"name":"NHS South Tees Hospital , Northallerton","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine","place":["Hershey, PA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Orihara","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine","place":["Hershey, PA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Navas","sequence":"additional","affiliation":[{"name":"NCH Healthcare System","place":["Naples, Florida"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Loma Linda University Hospital","place":["Loma Linda, CA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine","place":["Hershey, PA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer H.","family":"Kubo","sequence":"additional","affiliation":[{"name":"United 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