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Pre-clinical studies demonstrate that CCR2 inhibition reduces AAA formation, expansion, and progression in animal models. Emerging imaging techniques have validated CCR2 as a biomarker for AAA instability in humans. Although clinical trials targeting CCR2 are currently limited in number, ongoing translational studies highlight that CCR2 blockade is a promising therapeutic strategy to mitigate AAA expansion and the risk of rupture. This review underscores the potential of CCR2-targeting interventions to fill a critical unmet need to develop effective medical therapies for longitudinal clinical AAA management.<\/jats:p>","DOI":"10.3389\/fcvm.2026.1772497","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T16:49:02Z","timestamp":1771346942000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of CCR2\/CCL2 molecular axis in the expansion and rupture of abdominal aortic aneurysms"],"prefix":"10.3389","volume":"13","author":[{"given":"Ryan","family":"Wahidi","sequence":"first","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery, Washington University School of Medicine","place":["St. Louis, MO, United States"]},{"name":"Cardiovascular Research Innovation in Surgery and Engineering Center, Department of Surgery, Washington University in St. Louis","place":["St. Louis, MO, United 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