{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:06:07Z","timestamp":1780031167420,"version":"3.53.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulsed-field ablation (PFA) is a non-thermal energy source for pulmonary vein isolation (PVI). Data comparing the biological impact of different PFA technologies remain limited. This study assessed changes in biomarkers of hemolysis, inflammation, and biochemical myocardial injury using two PFA systems: a balloon-in-basket (BiB) and a circular catheter (PS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, single-center, non-randomized study enrolled consecutive patients undergoing first-time PVI. leukocytes, C-reactive protein (CRP), platelets, lactate dehydrogenase (LDH), haptoglobin, total bilirubin, troponin T, creatine kinase (CK), myoglobin, creatinine, and estimated glomerular filtration rate (eGFR) were before and 16\u201318\u2005h after ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty patients were included (BiB\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920, PS\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920). Baseline characteristics were comparable. Acute PVI was achieved in all cases. BiB required fewer applications (16 vs. 32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), more contrast (45 vs. 30\u2005mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), and had longer procedure and LA dwell times (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Both systems caused significant increases in leukocytes, CRP, LDH, troponin, and CK without inter-group differences. Haptoglobin decreased significantly in both, more pronounced with PS (\u0394 \u221213 vs. \u22124\u2005mg\/dL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.090). Renal function remained stable overall, with one PS patient developing an acute kidney injury. In the BiB group, \u0394-Hemoglobin correlated inversely with application number (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046). In the PS group,\n                      <jats:italic>\u0394<\/jats:italic>\n                      -Troponin and\n                      <jats:italic>\u0394<\/jats:italic>\n                      -CK correlated positively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite comparable overall biomarker responses, a numerically greater, non-significant haptoglobin decline and an isolated, likely multifactorial transient AKI in the PS group may suggest differences in biomarker responses, warranting further investigation in larger studies. However, the clinical relevance of these findings remains uncertain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1774443","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:51:57Z","timestamp":1780030317000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential biomarker responses of hemolysis, inflammation, and myocardial injury after pulsed-field pulmonary vein isolation: balloon-in-basket vs. circular catheter systems"],"prefix":"10.3389","volume":"13","author":[{"given":"Jan-Per","family":"Wenzel","sequence":"first","affiliation":[{"name":"Department of Rhythmology, Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein","place":["L\u00fcbeck, Germany"]},{"name":"German Center for Cardiovascular Research (DZHK)","place":["Partner Site, L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed","family":"Abdessadok","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein","place":["L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Eitel","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein","place":["L\u00fcbeck, Germany"]},{"name":"German Center for Cardiovascular Research (DZHK)","place":["Partner Site, L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein","place":["L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"de Waha","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein","place":["L\u00fcbeck, Germany"]},{"name":"German Center for Cardiovascular Research (DZHK)","place":["Partner Site, L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Zeller","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK)","place":["Partner Site, L\u00fcbeck, Germany"]},{"name":"Institute for Cardiogenetics, University Hospital Schleswig-Holstein","place":["L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Kuck","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein","place":["L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Richard","family":"Tilz","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein","place":["L\u00fcbeck, Germany"]},{"name":"German Center for Cardiovascular Research (DZHK)","place":["Partner Site, L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Hatahet","sequence":"additional","affiliation":[{"name":"Department of Rhythmology, Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein","place":["L\u00fcbeck, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1056\/NEJMoa2307291","article-title":"Pulsed field or conventional thermal ablation for paroxysmal atrial fibrillation","volume":"389","author":"Reddy","year":"2023","journal-title":"N Engl J 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