{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:15:45Z","timestamp":1783430145499,"version":"3.54.6"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non-bacterial thrombotic endocarditis (NBTE) is a rare, sterile valvular condition associated with hypercoagulable states, malignancy, or autoimmune diseases. Diagnosis is challenging due to nonspecific symptoms and unknown cause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      A 14-year-old male presented with acute-onset severe abdominal pain. Imaging studies revealed extensive thrombi involving multiple organ veins, as well as a large vegetation on the tricuspid valve, consistent with NBTE. Although routine thrombophilia screening was unremarkable, a significant family history of thrombotic events prompted further genetic evaluation. Whole-exome sequencing identified a pathogenic heterozygous variant in the\n                      <jats:italic>F2<\/jats:italic>\n                      gene (\n                      <jats:italic>F2<\/jats:italic>\n                      c.1621C\u2009&amp;gt;\u2009T, p.Arg541Trp), confirming an underlying hereditary thrombophilia. The patient underwent successful surgical excision of the vegetation with tricuspid valve repair. Anticoagulation therapy resulted in complete resolution of symptoms, and long-term management was initiated to mitigate recurrent thrombosis risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome<\/jats:title>\n                    <jats:p>At one-year follow-up, repeat imaging showed recanalization of the portal and splenic veins without recurrent thrombosis, underscoring the effectiveness of anticoagulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case demonstrates an atypical NBTE presentation with tricuspid valve involvement and extensive venous thrombosis due to a rare\n                      <jats:italic>F2<\/jats:italic>\n                      mutation. The successful treatment reflects the importance of early recognition, multidisciplinary management and detailed consultation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1775477","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:34:11Z","timestamp":1783427651000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Non-bacterial thrombotic endocarditis and multiple thrombi uncover a hidden prothrombotic mutation"],"prefix":"10.3389","volume":"13","author":[{"given":"Yongchao","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, 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