{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:09:05Z","timestamp":1780463345144,"version":"3.54.1"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endothelial dysfunction and inflammation play a key role in the pathophysiology of acute coronary syndrome (ACS). Endocan has emerged as a novel biomarker reflecting endothelial activation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate serum endocan levels in patients with non\u2013ST-segment elevation myocardial infarction (NSTEMI) and their association with coronary stenosis severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study included 81 NSTEMI patients undergoing coronary angiography. Patients were classified into clinically significant coronary stenosis and non-significant coronary stenosis groups. Serum endocan levels were measured at admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients who underwent coronary angiography (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200981) were divided into two groups as those with clinically significant coronary stenosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) and non-significant coronary stenosis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200941). Serum endocan levels were significantly higher in the group with clinically significant coronary stenosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Mean age and body mass index (BMI) were higher and statistically significant in the group with clinically significant coronary stenosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042). Inflammation parameters C-reactive protein (CRP), White Blood Cell (WBC) and Neutrophil Lymphocyte ratio (NLR) were higher in the group with clinically significant coronary stenosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038). In multivariate logistic regression analysis, endocan (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001, 95% CI: 1.010\u20131.035), BMI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020, 95% CI: 1.070\u20132.237), and CRP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039, 95% CI: 1.003\u20131.099) were independently associated with clinically significant coronary stenosis. In Receiver operating curve (ROC) analysis performed to discriminate between patients with and without clinically significant coronary stenosis, the endocan cut-off value was determined as\u2009&amp;gt;\u2009393.1\u2005ng\/L [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001, The Area Under the Curve (AUC)\u2009=\u20090.826, 95% CI\u2009=\u20090.732\u20130.919, Likelihood Ratio +\u2009=\u20097.65, LR -\u2009=\u20090.28].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Endocan levels are elevated in NSTEMI patients with clinically significant coronary stenosis and may reflect endothelial dysfunction and atherosclerotic burden.<\/jats:p>\n                  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