{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:00:57Z","timestamp":1785326457839,"version":"3.55.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is a prevalent sleep-disordered breathing condition associated with atrial fibrillation (AF) and cardiovascular morbidity. Its impact on life-threatening arrhythmic events, including cardiac arrest (CA) and ventricular fibrillation (VF), in patients with ischemic heart disease (IHD) and hypertrophic cardiomyopathy (HCM) remains incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to evaluate the association between OSA and arrhythmic outcomes in patients with IHD or HCM and to explore the potential role of AF as an intermediate pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the National Inpatient Sample (2016\u20132020), we identified adults with IHD or HCM. OSA and arrhythmic events were defined by ICD-10 codes. Baseline characteristics were compared, and 1:1 propensity score matching (PSM) was performed. Multivariate logistic regression assessed the relationship between OSA and AF, AF and the composite endpoint of CA\/VF, and the combined effect of OSA and AF in hierarchical models. Odds ratios (ORs) with 95% confidence intervals (CIs) were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 20,590 patients, 3,974 (19.3%) had OSA. OSA was independently associated with AF (OR 1.37, 95% CI 1.15\u20131.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). AF was a strong predictor of CA\/VF (OR 13.88, 95% CI 10.70\u201318.01,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). In hierarchical models, the effect of OSA on CA\/VF was attenuated and non-significant (OR 1.14, 95% CI 0.96\u20131.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.13), whereas AF remained robustly associated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with IHD or HCM, OSA was associated with a higher prevalence of AF, which may represent an important intermediate pathway associated with life-threatening arrhythmic events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1793921","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:10:25Z","timestamp":1785323425000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of obstructive sleep apnea on arrhythmic risk in ischemic heart disease and hypertrophic cardiomyopathy: insights from a large national cohort"],"prefix":"10.3389","volume":"13","author":[{"given":"Qingqing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Cardiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Clinical Research Center for Metabolic Heart Disease of Fujian Province","place":["Fuzhou, China"]},{"name":"Key Laboratory of Metabolic Heart Disease in Fujian Province","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Cardiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Clinical Research Center for Metabolic Heart Disease of Fujian Province","place":["Fuzhou, China"]},{"name":"Key Laboratory of Metabolic Heart Disease in Fujian Province","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Department of Cardiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital of Fujian Medical University","place":["Fuzhou, China"]},{"name":"Clinical Research Center for Metabolic Heart Disease of Fujian Province","place":["Fuzhou, China"]},{"name":"Key Laboratory of Metabolic Heart Disease in Fujian Province","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/s41392-023-01496-3","article-title":"Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome","volume":"8","author":"Lv","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.3390\/jcm13113223","article-title":"The effects of obstructive sleep apnea on the cardiovascular system: a comprehensive review","volume":"13","author":"DiCaro","year":"2024","journal-title":"J Clin Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.chest.2016.09.014","article-title":"OSA and cardiac 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