{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:27:15Z","timestamp":1787218035741,"version":"build-2736575974"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac involvement by extranodal natural killer\/T-cell lymphoma (ENKTL) and aggressive NK-cell leukaemia (ANKL) is exceedingly rare and presents with heterogeneous manifestations, often leading to diagnostic uncertainty and delay. We contribute three additional biopsy- or autopsy-proven cases and place them in the context of a literature review of previously reported cases classified according to the 5th edition of the World Health Organization (WHO) Classification of Hematolymphoid Tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case series<\/jats:title>\n                    <jats:p>Three men (ages 58\u201372) presented with diverse cardiac manifestations. A 72-year-old with progressive dyspnoea and cardiogenic shock had cMRI findings interpreted as myocarditis on an infiltrative substrate; endomyocardial biopsy confirmed cardiac infiltration by ENKTL. Despite brentuximab vedotin (BV)-based therapy he died shortly thereafter. A 60-year-old with encephalopathy, biventricular dysfunction, and widespread nodal\/multiorgan disease had nodal pathology consistent with EBV-negative ANKL according to the criteria of the 5th edition of the WHO Classification of Hematolymphoid Tumors; he declined chemotherapy and died within six days, with autopsy confirming multiorgan (including myocardial and bone marrow) infiltration. A 58-year-old with prior sinonasal ENKTL treated with four cycles of SMILE developed a new right atrial mass one month later; the mass was diagnosed by cMRI\/PET-CT concordance and an extracardiac (EBUS-lung) tissue confirmation of the same recurrence. BV followed by gemcitabine\/oxaliplatin failed to control progression and he died approximately one month after cardiac spread. Across cases, CD56 was positive in all, EBER in two, and CD30 was expressed variably.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cardiac ENKTL\/ANKL is a rapidly fatal entity with protean features. Multimodal imaging aids early recognition and tissue targeting, but definitive diagnosis rests on tissue confirmation. L-asparaginase-based chemotherapy remains the treatment backbone; CD30- and PD-L1-guided agents such as BV, PD-1 blockade, and daratumumab may offer transient control after biomarker-guided selection but lack randomized data in cardiac disease. Across the reported experience, survival after cardiac involvement was uniformly short, typically days to a few months. Our three cases add to this literature by illustrating the diversity of cardiac presentations, the variable CD30 expression relevant to brentuximab vedotin use, and the contribution of multimodal imaging to diagnosis. Findings from our series and the pooled literature are descriptive rather than constituting a formal survival analysis, and underscore the need for earlier diagnosis and prospective investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1794186","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:10:27Z","timestamp":1787217027000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Clinical characteristics and outcomes in natural killer (NK)\/T-cell lymphomas with cardiac involvement: a case series and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Guy","family":"Robinson","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyan","family":"Heybati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic","place":["Rochester, MN, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Tayon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupashi","family":"Mukhia","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Yang","sequence":"additional","affiliation":[{"name":"The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine","place":["Chicago, IL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan C.","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivienne","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Tun","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Mayo Clinic","place":["Jacksonville, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1002\/cncr.30697","article-title":"The impact of the omission or inadequate dosing of radiotherapy in extranodal natural killer T-cell lymphoma, nasal type, in the United States","volume":"123","author":"Vargo","year":"2017","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1182\/blood-2017-12-791418","article-title":"Advances in the treatment of extranodal NK\/T-cell lymphoma, nasal type","volume":"131","author":"Yamaguchi","year":"2018","journal-title":"Blood"},{"key":"B3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13045-022-01293-5","article-title":"How we treat NK\/T-cell lymphomas","volume":"15","author":"Tse","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1590\/s0004-27492012000600013","article-title":"Ocular masquerade syndrome associated with extranodal nasal natural killer\/T-cell lymphoma: case report","volume":"75","author":"Abe","year":"2012","journal-title":"Arq Bras Oftalmol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.2169\/internalmedicine.53.2764","article-title":"Cardiac involvement in CD56 negative primary pancreatic extranodal NK\/T-cell lymphoma, nasal type, presenting with ventricular tachycardia during the early stages of chemotherapy","volume":"53","author":"Baek","year":"2014","journal-title":"Intern Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/jha2.396","article-title":"A rare case of massive myocardial infiltration by a disseminated extra-nodal NK\/T-cell lymphoma","volume":"3","author":"Bayoudh","year":"2022","journal-title":"EJHaem"},{"key":"B7","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1177\/0218492318798230","article-title":"Primary cardiac natural killer\/T-cell lymphoma, a very rare form of lymphoma","volume":"27","author":"Farf\u00e1n-Leal","year":"2019","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"B8","doi-asserted-by":"publisher","first-page":"337","DOI":"10.30699\/IJP.2021.139566.2524","article-title":"Cardiac involvement and subsequent death due to extranodal NK\/T cell cutaneous T-cell lymphoma: an autopsy case and brief review of the literature","volume":"16","author":"Goutas","year":"2021","journal-title":"Iran J Pathol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e833","DOI":"10.1200\/JCO.2011.36.7276","article-title":"Cardiac involvement of natural killer\/T-cell lymphoma presenting with electrical storm after cardioverter-defibrillator implantation","volume":"29","author":"Huang","year":"2011","journal-title":"J Clin Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1080\/02841860902740923","article-title":"Malignant arrhythmia: a case report of nasal NK\/T-cell lymphoma with cardiac involvement","volume":"48","author":"Kanesvaran","year":"2009","journal-title":"Acta Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1080\/10428190801947518","article-title":"A case of primary cutaneous natural killer\/T-cell lymphoma, nasal type, directly invading to the heart","volume":"49","author":"Kawasaki","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"B12","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12308-023-00572-5","article-title":"Initial diagnosis of extranodal NK\/T-cell lymphoma in pericardial fluid with concomitant hemophagocytic lymphohistiocytosis (HLH)","volume":"17","author":"Khasawneh","year":"2024","journal-title":"J Hematop"},{"key":"B13","doi-asserted-by":"publisher","first-page":"ytac363","DOI":"10.1093\/ehjcr\/ytac363","article-title":"Cardiac relapse of extranodal NK\/T-cell lymphoma manifesting as incessant ventricular tachycardia: a case report","volume":"6","author":"Kolesnik","year":"2022","journal-title":"Eur Heart J Case Rep"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e233190","DOI":"10.1136\/bcr-2019-233190","article-title":"Heart failure enigma in young man: the acute onset of a frequently encountered condition with an unexpected cause","volume":"13","author":"Leonor Lopez","year":"2020","journal-title":"BMJ Case Rep"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.4081\/hr.2011.e9","article-title":"Extranodal NK\/T-cell lymphoma presenting with primary cardiac involvement","volume":"3","author":"Lepeak","year":"2011","journal-title":"Hematol Rep"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2394809","DOI":"10.1155\/2016\/2394809","article-title":"Extranodal NK\/T cell lymphoma causing cardiorespiratory failure","volume":"2016","author":"Li","year":"2016","journal-title":"Case Rep Hematol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1548785","DOI":"10.3389\/fonc.2025.1548785","article-title":"The role of F-FDG PET\/CT in diagnosing cardiac infiltration and therapeutic evaluation in extranodal nasal-type NK\/T-cell lymphoma: a case report","volume":"15","author":"Liao","year":"2025","journal-title":"Front Oncol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e2021246","DOI":"10.4322\/acr.2021.246","article-title":"Extranodal NK\/T-cell lymphoma, nasal type with extensive cardiopulmonary involvement","volume":"11","author":"Marques-Piubelli","year":"2021","journal-title":"Autops Case Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1159\/000487268","article-title":"Beneath the retinal pigment epithelium: histopathologic findings in metastatic extranodal natural killer\/T-cell lymphoma, nasal type","volume":"4","author":"Thompson","year":"2018","journal-title":"Ocul Oncol Pathol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1011894","DOI":"10.3389\/fonc.2022.1011894","article-title":"Extranodal natural killer\/T-cell lymphoma invading a patient's Heart: a rare case report and literature review","volume":"12","author":"Xiang","year":"2022","journal-title":"Front Oncol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"394","DOI":"10.21037\/tcr.2019.11.42","article-title":"Rarely seen primary cardiac natural killer\/T cell lymphoma: a case report","volume":"9","author":"Yang","year":"2020","journal-title":"Transl Cancer Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"685736","DOI":"10.3389\/fcvm.2021.685736","article-title":"Progressive heart failure and death as the initial manifestation of NK\/T-cell lymphoma: a case report and literature review","volume":"8","author":"Zhang","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e45817","DOI":"10.1097\/MD.0000000000045817","article-title":"Nasal-type NK\/T-cell lymphoma with concurrent myocardial and central nervous system involvement: a rare case report","volume":"104","author":"Huang","year":"2025","journal-title":"Medicine (Baltimore)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"S881","DOI":"10.1016\/S2152-2650(25)02530-3","article-title":"TCL-1291: atypical relapse of extranodal NK\/T-cell lymphoma with cardiac and adrenal involvement [abstract]","volume":"25","author":"Singh","year":"2025","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1093\/eurheartj\/ehm218","article-title":"Pericardial involvement in a non-hodgkin lymphoma patient: coregistered FDG-PET and CT imaging","volume":"28","author":"Weijs","year":"2007","journal-title":"Eur Heart J"},{"key":"B26","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.tcm.2021.08.010","article-title":"The role of cardiac CT and MRI in the diagnosis and management of primary cardiac lymphoma: a comprehensive review","volume":"32","author":"Asadian","year":"2022","journal-title":"Trends Cardiovasc Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the world health organization classification of haematolymphoid tumours: lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"B28","doi-asserted-by":"publisher","first-page":"21621","DOI":"10.1038\/s41598-025-05843-y","article-title":"Genetic and clinical distinction between aggressive NK-cell leukemia and extranodal NK\/T-cell lymphoma with bone marrow involvement","volume":"15","author":"Lee","year":"2025","journal-title":"Sci Rep"},{"key":"B29","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00277-008-0494-8","article-title":"Fluorine-18 fluorodeoxyglucose positron emission tomography in mature T-cell and natural killer cell malignancies","volume":"87","author":"Khong","year":"2008","journal-title":"Ann Hematol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1097\/RLU.0b013e3181e4dcbf","article-title":"Metabolic activity measured by F-18 FDG PET in natural killer-cell lymphoma compared to aggressive B- and T-cell lymphomas","volume":"35","author":"Chan","year":"2010","journal-title":"Clin Nucl Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00277-023-05562-2","article-title":"Appropriate timing to perform an interim F-FDG PET\/CT in patients with nasal-type extranodal natural killer\/T cell lymphoma","volume":"103","author":"Wang","year":"2024","journal-title":"Ann Hematol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/s12149-015-0964-8","article-title":"Assessment of the prognostic capacity of pretreatment, interim, and post-therapy (18)F-FDG PET\/CT in extranodal natural killer\/T-cell lymphoma, nasal type","volume":"29","author":"Jiang","year":"2015","journal-title":"Ann Nucl Med"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s00277-021-04466-3","article-title":"Dynamic evaluation of the prognostic value of 18F-FDG PET\/CT in extranodal NK\/T-cell lymphoma, nasal type","volume":"100","author":"Xu","year":"2021","journal-title":"Ann Hematol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1007\/s00259-021-05232-3","article-title":"Weakly supervised deep learning for determining the prognostic value of F-FDG PET\/CT in extranodal natural killer\/T cell lymphoma, nasal type","volume":"48","author":"Guo","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"B35","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1097\/RLU.0000000000000892","article-title":"The deauville 5-point scale improves the prognostic value of interim FDG PET\/CT in extranodal natural killer\/T-cell lymphoma","volume":"40","author":"Jiang","year":"2015","journal-title":"Clin Nucl Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/modpathol.3800157","article-title":"Nasal-type extranodal natural killer\/T-cell lymphomas: a clinicopathologic and genotypic study of 42 cases in Singapore","volume":"17","author":"Ng","year":"2004","journal-title":"Mod Pathol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.cardfail.2024.08.045","article-title":"Cardio-Oncology and heart failure: a scientific statement from the heart failure society of America","volume":"31","author":"Bloom","year":"2025","journal-title":"J Card Fail"},{"key":"B38","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.beha.2019.06.005","article-title":"NK\/T-cell lymphomas","volume":"32","author":"Tse","year":"2019","journal-title":"Best Pract Res Clin Haematol"},{"key":"B39","volume-title":"Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book)FDA","year":""},{"key":"B40","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.1182\/blood.2019001821","article-title":"Brentuximab vedotin in the treatment of CD30+ PTCL","volume":"134","author":"Barta","year":"2019","journal-title":"Blood"},{"key":"B41","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00277-022-05054-9","article-title":"Anti-CD30 antibody-drug conjugate therapy in lymphoma: current knowledge, remaining controversies, and future perspectives","volume":"102","author":"Prince","year":"2023","journal-title":"Ann Hematol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1182\/blood-2013-12-542142","article-title":"Objective responses in relapsed T-cell lymphomas with single-agent brentuximab vedotin","volume":"123","author":"Horwitz","year":"2014","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.3109\/10428194.2014.974048","article-title":"Prognostic implications of CD30 expression in extranodal natural killer\/T-cell lymphoma according to treatment modalities","volume":"56","author":"Kim","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"B44","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1309\/V561QTM6854W4WAV","article-title":"Immunohistochemical characterization of nasal-type extranodal NK\/T-cell lymphoma using a tissue microarray: an analysis of 84 cases","volume":"130","author":"Schwartz","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/PAS.0000000000002184","article-title":"EBV-positive Nodal T-cell and NK-cell lymphoma: a study of 26 cases including a subset with strong CD30 expression mimicking anaplastic large cell lymphoma","volume":"48","author":"Yu","year":"2024","journal-title":"Am J Surg Pathol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00277-016-2818-4","article-title":"Expression of programmed cell death 1 and programmed cell death ligand 1 in extranodal NK\/T-cell lymphoma, nasal type","volume":"96","author":"Jo","year":"2017","journal-title":"Ann Hematol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00428-016-2011-0","article-title":"Expression of programmed cell death ligand 1 (PD-L1) in advanced stage EBV-associated extranodal NK\/T cell lymphoma is associated with better prognosis","volume":"469","author":"Kim","year":"2016","journal-title":"Virchows Arch"},{"key":"B48","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/ehf2.13693","article-title":"99mTechnetium-Pyrophosphate Scintigraphy: a practical guide for early diagnosis of transthyretin amyloid cardiomyopathy","volume":"9","author":"Tahara","year":"2022","journal-title":"ESC Heart Fail"},{"key":"B49","doi-asserted-by":"publisher","first-page":"ytab321","DOI":"10.1093\/ehjcr\/ytab321","article-title":"Grade 3 myocardial uptake in 99mTc-pyrophosphate scintigraphy in light chain cardiac amyloidosis","volume":"5","author":"Okada","year":"2021","journal-title":"Eur Heart J Case Rep"},{"key":"B50","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.hfc.2023.03.009","article-title":"Viral myocarditis and dilated cardiomyopathy as a consequence: changing insights from advanced imaging","volume":"19","author":"Kang","year":"2023","journal-title":"Heart Fail Clin"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.hrthm.2014.03.043","article-title":"HRS Expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis","volume":"11","author":"Birnie","year":"2014","journal-title":"Heart Rhythm"},{"key":"B52","doi-asserted-by":"publisher","first-page":"27","DOI":"10.15406\/htij.2023.11.00303","article-title":"Primary cardiac lymphoma: a comprehensive review","volume":"11","author":"Zhao","year":"2023","journal-title":"Hematol Transfus Int J"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1002\/ajh.26200","article-title":"Outcome after hematopoietic stem cell transplantation in patients with extranodal natural killer\/T-cell lymphoma, nasal type: a French study from the SFGM-TC","volume":"96","author":"Philippe Walter","year":"2021","journal-title":"Am J Hematol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1182\/blood-2018-01-791335","article-title":"Allogeneic hematopoietic stem cell transplantation for T-cell lymphomas","volume":"132","author":"Schmitz","year":"2018","journal-title":"Blood"},{"key":"B55","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13045-018-0559-7","article-title":"Activity of pembrolizumab in relapsed\/refractory NK\/T-cell lymphoma","volume":"11","author":"Li","year":"2018","journal-title":"J Hematol Oncol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3080","DOI":"10.1182\/blood-2023-184325","article-title":"Pembrolizumab in relapsed\/refractory extranodal NK\/T-cell lymphoma and mature T-cell lymphoma: a prospective phase II study","volume":"142","author":"Chan","year":"2023","journal-title":"Blood"},{"key":"B57","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s41392-021-00768-0","article-title":"Sintilimab for relapsed\/refractory extranodal NK\/T-cell lymphoma: a multicenter, single-arm, phase 2 trial (ORIENT-4)","volume":"6","author":"Tao","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e013757","DOI":"10.1161\/JAHA.119.013757","article-title":"Immune checkpoint inhibitor myocarditis: pathophysiological characteristics, diagnosis, and treatment","volume":"9","author":"Palaskas","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"B59","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13045-020-01020-y","article-title":"Daratumumab monotherapy for patients with relapsed or refractory natural killer\/T-cell lymphoma, nasal type: an open-label, single-arm, multicenter, phase 2 study","volume":"14","author":"Huang","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"76","DOI":"10.25259\/JHAS_33_2024","article-title":"Can targeted therapy improve outcome in epstein\u2013barr virus-negative aggressive natural killer cell leukemia: a case report","volume":"4","author":"Saxena","year":"2024","journal-title":"J Hematol Allied Sci"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1794186\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:10:28Z","timestamp":1787217028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1794186\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":60,"alternative-id":["10.3389\/fcvm.2026.1794186"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2026.1794186","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"article-number":"1794186"}}