{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:01:43Z","timestamp":1780916503402,"version":"3.54.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to investigate the real-world experience of drug-coated balloon (DCB) in coronary intervention therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a single-center, retrospective study included 1,118 patients who underwent DCB treatment at Shanghai Putuo Central Hospital from January 2019 to December 2023, with a follow-up period ranging from 2 to 5 years. Clinical data, biochemical test results, interventional parameters, and clinical follow-up data of patients were collected, the effectiveness and safety of DCB in a real-world setting were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 1,118 patients who underwent drug-coated balloon (DCB) treatment, the incidence of major adverse cardiovascular events (MACE) was 17.1% (191 cases), including 21 deaths (1.9%), 14 recurrent myocardial infarctions (1.3%), and 167 target vessel revascularizations (14.9%). Procedural coronary artery dissection occurred in 144 patients (12.9%). Multivariable Cox regression analysis identified cutting balloon use (HR\u2009=\u20092.07; 95% CI: 1.31\u20133.28;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002) and smoking (HR\u2009=\u20097.65; 95% CI: 5.51\u201310.62;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) as independent risk factors for MACE. Conversely, larger culprit vessel diameter (HR\u2009=\u20090.22; 95% CI: 0.14\u20130.35;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) wa\n                      <jats:underline>s<\/jats:underline>\n                      independently associated with a reduced risk of MACE after DCB treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this real-world cohort of patients undergoing DCB-based coronary intervention, mortality and recurrent MI were infrequent, whereas MACE occurred in nearly one-fifth of the cohort, predominantly driven by TVR. Target vessel revascularization was associated with culprit vessel diameter, cutting balloon use, smoking status, vascular calcification, bailout stenting, and culprit vessel length.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1794399","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:52:18Z","timestamp":1779339138000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A single-centre real-world study on the application of drug-coated balloons in coronary intervention therapy"],"prefix":"10.3389","volume":"13","author":[{"given":"Chen","family":"Shuangyu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, 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