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The integrin-dependent and -independent downstream signals of Kindlin-2 is now widely recognized to be essential in many events in cardiovascular system including angiogenesis, vascular permeability, cardiac development. Furthermore, the important role of Kindlins has been demonstrated in the pathogenesis of arteriosclerosis, ischemia\/reperfusion injury, acute lung injury, pulmonary hypertension, heart failure and even osteoporosis. 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