{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:09:16Z","timestamp":1779253756193,"version":"3.51.4"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac injury is a common complication following intracerebral hemorrhage (ICH), contributing to poor prognosis. Systemic inflammation has been proposed as a critical mediator along the brain-heart axis, linking neurological injury to remote cardiac damage. This study aimed to investigate the association between a composite inflammatory indicator and acute cardiac injury following ICH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single-center retrospective cohort study included patients with ICH admitted within 24\u2005h of symptom onset between 2017 and 2022. Composite inflammatory indices (\n                      <jats:italic>N<\/jats:italic>\n                      LR, PLR, MLR, SII, SIRI, AISI) were derived from admission peripheral blood cell counts. The primary outcome, acute cardiac injury, was defined as a hs-cTnT level &amp;gt;0.014\u2005ng\/mL accompanied by at least one electrocardiographic abnormality. Independent associations were evaluated using multivariable logistic regression, with dose-response relationships assessed via trend tests. Mediation analyses were conducted using PROCESS macro (models 4 and 6). Robustness was examined through stratified and sensitivity analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acute cardiac injury occurred in 166 (29.5%) of the 562 patients. The injury group showed significantly elevated levels of MLR, SIRI, and AISI compared to the non-injury group, each of which independently associated with cardiac injury after multivariable adjustment. These inflammatory indices partially mediated the link between lower Glasgow Coma Scale (GCS) scores and cardiac injury. A significant chain mediation pathway was identified: lower GCS\u2009\u2192\u2009elevated SIRI\u2009\u2192\u2009increased hs-cTnT\u2009\u2192\u2009higher 90-day mortality. The findings were robust in stratified and sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MLR, SIRI, and AISI serve as independent factors of acute cardiac injury after intracerebral hemorrhage and play a significant mediating role in the brain-heart axis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1798009","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:33:10Z","timestamp":1779251590000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic inflammatory indexes mediate cardiac injury following intracerebral hemorrhage"],"prefix":"10.3389","volume":"13","author":[{"given":"Tao","family":"Ran","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Cardiovascular Research Center, The First 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China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Song","family":"Yang","sequence":"additional","affiliation":[{"name":"Departments of Neurology, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, 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