{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:15:37Z","timestamp":1778652937878,"version":"3.51.4"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Kawasaki disease (KD) is the leading cause of acquired pediatric heart disease, characterized by acute systemic vasculitis. We report a 7-year-6-month-old boy with typical KD [meeting the 2017 American Heart Association (AHA) diagnostic criteria] who responded completely to initial intravenous immunoglobulin (IVIG) therapy (2\u2005g\/kg), with rapid defervescence and normalized inflammatory markers. Despite this favorable initial response and no coronary abnormalities, he uniquely developed a triad of acute heart failure with cardiomegaly [New York Heart Association (NYHA) class II], severe hypertension (&amp;gt;\u200999th percentile), and early glomerular injury (elevated urinary albumin-to-creatinine ratio, urinary transferrin, and urinary albumin) during the clinically quiescent subacute phase. This \u201cinflammatory-silent but vascular-loud\u201d phenotype underscores that effective initial treatment and normalization of inflammatory markers do not equate to vascular safety, highlighting persistent endothelial dysfunction as a critical driver of morbidity. The case supports redefining subacute-phase monitoring to include blood pressure surveillance, comprehensive echocardiographic assessment of chamber dimensions and function, and screening for early glomerular injury.<\/jats:p>","DOI":"10.3389\/fcvm.2026.1804390","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:56:07Z","timestamp":1778651767000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A triad of hypertension, heart failure, and glomerular injury in subacute Kawasaki disease: a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Qian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Emergency, Wuhan Children\u2019s Hospital, Tongji Medical College, Huazhong University of Science & Technology","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Wuhan Children\u2019s Hospital, Tongji Medical College, Huazhong University of Science & Technology","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Emergency, Wuhan Children\u2019s Hospital, Tongji Medical College, Huazhong University of Science & Technology","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Emergency, Wuhan Children\u2019s Hospital, Tongji Medical College, Huazhong University of Science & Technology","place":["Wuhan, Hubei, 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