{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:02:55Z","timestamp":1779951775717,"version":"3.53.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Childhood hypertension and obesity are among the most prevalent health conditions worldwide, with obesity increasing the risk of hypertension in children. However, there has been limited focus on children with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To identify the risk factors of hypertension in children with obesity and the relationship between them, we collected information from children who were registered at the Child Health Development Center of Hunan Children's Hospital between October 2021 and December 2023. Logistic regression combined with restricted cubic spline was used to examine the relationship between the variables and hypertension in children with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 756 children with obesity were included in the study. The detection rate of hypertension in children with obesity was 20.6%, with a mean age of 11.9\u00b12.0 years. The logistic regression indicated that neutrophils (NE), the ratio of neutrophils to lymphocytes (NLR), platelet count (PLT), albumin (ALB) and triglycerides (TG) were independent risk factors for hypertension in children with obesity. Restricted cubic spline curves showed NE, NLR, PLT, ALB and TG increasing linearly with the risk of hypertension. There was a significant linear relationship between NE, NLR, ALB, TG and systolic blood pressure (SBP)\/diastolic blood pressure (DBP). A nonlinear dose-response relationship is observed between PLT and SBP, but no dose-response relationship between PLT and DBP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Elevated levels of NE, NLR, PLT, ALB, and TG are associated with hypertension in children with obesity. Future studies need normal-weight controls to better examine these links.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1805009","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:19:08Z","timestamp":1779949148000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["An evaluation of factors associated with hypertension in children and adolescents with obesity"],"prefix":"10.3389","volume":"13","author":[{"given":"Kexin","family":"Zhou","sequence":"first","affiliation":[{"name":"Pediatrics Research Institute of Hunan Province, Hunan Children\u2019s Hospital","place":["Changsha, China"]},{"name":"School of Public Health, Changsha Medical University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Cai","sequence":"additional","affiliation":[{"name":"Child Health Development Center, Hunan Children\u2019s Hospital","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiting","family":"Xiang","sequence":"additional","affiliation":[{"name":"Pediatrics Research Institute of Hunan Province, Hunan Children\u2019s Hospital","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Wei","sequence":"additional","affiliation":[{"name":"Xiangya School of Public Health, Central South University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manxin","family":"Deng","sequence":"additional","affiliation":[{"name":"Pediatrics Research Institute of Hunan Province, Hunan Children\u2019s Hospital","place":["Changsha, China"]},{"name":"School of Public Health, Changsha Medical University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Pediatrics Research Institute of Hunan Province, Hunan Children\u2019s Hospital","place":["Changsha, China"]},{"name":"School of Public Health, Changsha Medical University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tan","sequence":"additional","affiliation":[{"name":"Child Health Development Center, Hunan Children\u2019s Hospital","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Pediatric Orthopedics, Hunan children\u2019s Hospital","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Public Health, Changsha Medical University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Child Health Development Center, Hunan Children\u2019s Hospital","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemei","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Public Health, Changsha Medical University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Pediatrics Research Institute of Hunan Province, Hunan Children\u2019s Hospital","place":["Changsha, China"]},{"name":"School of Public Health, Changsha Medical University","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"B1","year":""},{"key":"B2","first-page":"521","article-title":"Bureau of Disease Prevention and Control, National Health Commission. 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