{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:55:17Z","timestamp":1781758517384,"version":"3.54.5"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Patients with obesity-related coronary heart disease continue to experience substantial residual cardiovascular risk despite progress in secondary prevention. We propose that this risk originates from a self-perpetuating cycle between inflammation and metabolism\u2014termed the inflammation-metabolism axis\u2014which extends beyond conventional risk factors. This axis forms a complex pathological network that existing single-target therapies cannot adequately address, representing a core mechanism of persistent residual risk. Effective management therefore requires integrated strategies capable of systemically modulating this network. Herbal medicines, with their inherent multi-target properties and network-level activity, offer a dual opportunity: they act as both potential therapeutic agents and as scientific tools for validating this integrative paradigm. This perspective article outlines the inflammation-metabolism axis as a unifying framework and discusses the rationale and future directions for developing systemic herbal-based interventions to mitigate residual cardiovascular risk.<\/jats:p>","DOI":"10.3389\/fcvm.2026.1806765","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:34:25Z","timestamp":1781757265000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond metabolism and blood flow: toward an inflammation-metabolism axis paradigm for herbal medicine in obesity-related coronary heart disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Jia-mei","family":"Fu","sequence":"first","affiliation":[{"name":"Second Department of Cardiology, First Afliated Hospital of Heilongjiang University of Chinese Medicine","place":["Harbin, China"]},{"name":"Postdoctoral Research Station of Heilongjiang University of Chinese 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