{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T06:15:11Z","timestamp":1783318511932,"version":"3.54.6"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to compare the impact of isolated innominate artery antegrade perfusion (IA) versus combined innominate and femoral artery perfusion (IA\u2009+\u2009FA) on surgical efficiency and short-term outcomes in patients undergoing surgery for acute type A aortic dissection (ATAAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single-center, retrospective cohort study was conducted involving 94 consecutive ATAAD patients who underwent surgery between May 2024 and May 2025. Patients were allocated into two groups based on the perfusion strategy: the IA group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956) and the IA\u2009+\u2009FA group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938). The primary endpoint was 30-day all-cause mortality. Secondary endpoints included total operative duration, aortic cross-clamp time, and the incidence of major postoperative complications (e.g., cerebral infarction, acute kidney injury, re-sternotomy). Statistical analyses were performed to compare intergroup differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two groups were well-balanced in terms of baseline demographics and preoperative risk profiles. The total operative time was significantly shorter in the IA group compared to the IA\u2009+\u2009FA group (370.05\u2009\u00b1\u200963.34\u2005min vs. 397.26\u2009\u00b1\u200962.11\u2005min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), while no significant differences were observed in aortic cross-clamp time or deep hypothermic circulatory arrest duration. Regarding safety outcomes, there were no statistically significant differences in 30-day mortality (10.71% vs. 21.05%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.28), postoperative cerebral infarction (14.29% vs. 15.79%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00), or acute kidney injury (21.43% vs. 26.32%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.76). However, numerical trends favoring the IA group were observed for rates of re-sternotomy and new requirement for hemodialysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For ATAAD surgery, an isolated innominate artery antegrade perfusion strategy significantly improves surgical efficiency by reducing operative time without compromising early safety outcomes, compared to a combined IA\u2009+\u2009FA approach. The routine addition of femoral artery perfusion did not confer measurable clinical benefits in this cohort. Thus, IA should be considered as a streamlined and efficient first-line perfusion strategy, potentially reserving IA\u2009+\u2009FA for select cases with specific indications. These findings warrant further validation in larger, prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1808621","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:37:21Z","timestamp":1783316241000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Innominate artery versus combined innominate and femoral artery perfusion in acute type A aortic dissection: a comparison of surgical efficiency and early outcomes"],"prefix":"10.3389","volume":"13","author":[{"given":"Lina","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, XuZhou Clinical School of Xuzhou Medical University","place":["Xuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, XuZhou Clinical School of Xuzhou Medical University","place":["Xuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e334","DOI":"10.1161\/CIR.0000000000001106","article-title":"2022 ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association\/American College of Cardiology joint committee on clinical practice guidelines","volume":"146","author":"Isselbacher","year":"2022","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.hjc.2024.10.001","article-title":"New guidelines of EACTS\/STS on aortic disease: a useful tool for the management of \u201caortic organ\u201d disease","volume":"84","author":"Schizas","year":"2025","journal-title":"Hellenic J Cardiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. 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