{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:05:07Z","timestamp":1789362307327,"version":"build-2803163510"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute myocardial infarction complicated by cardiogenic shock (AMICS) carries high in-hospital mortality. We evaluated the combined prognostic value of the Atherogenic Index of Plasma (AIP), reflecting lipid metabolism, and the Lactate-to-Albumin Ratio (LAR), reflecting tissue hypoperfusion and inflammation, in AMICS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort included 207 consecutive patients with AMICS between January 2023 and January 2025, classified as survivors (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009174) or non-survivors (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933). Admission clinical, laboratory, echocardiographic, and treatment variables were collected. Least Absolute Shrinkage and Selection Operator (LASSO) regression selected candidate predictors; multivariable logistic regression identified independent predictors and generated a nomogram. Performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration metrics, bootstrap internal validation, and decision curve analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Non-survivors had higher AIP (0.33\u2009\u00b1\u20090.23 vs. 0.06\u2009\u00b1\u20090.30) and LAR than survivors (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). LASSO identified six candidate predictors. Mechanical ventilation (OR\u2009=\u200910.10, 95% CI: 3.09\u201333.09,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), LVEF &amp;lt;40% (OR\u2009=\u20093.49, 95% CI: 1.23\u20139.90,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.019), AIP (OR\u2009=\u20094.30 per SD increase,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), and LAR (OR\u2009=\u20091.88 per SD increase,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005) were independently associated with in-hospital mortality. The combined model showed good-to-excellent internal discrimination (AUC\u2009=\u20090.909, bootstrap 95% CI: 0.853\u20130.957), exceeding AIP (AUC\u2009=\u20090.777) or LAR (AUC\u2009=\u20090.735) alone. Calibration was acceptable (Hosmer\u2013Lemeshow\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.853; Brier score\u2009=\u20090.077, bootstrap 95% CI: 0.052\u20130.103). The model underwent internal validation only and should be considered hypothesis-generating pending external validation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AIP and LAR were independently associated with in-hospital mortality and may reflect complementary lipid-metabolic and hypoperfusion-inflammatory pathways. The nomogram combines these biomarkers with hemodynamic and respiratory severity parameters and may support early risk stratification, but requires external multicenter validation before routine clinical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1816471","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:38:18Z","timestamp":1789360698000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of the atherogenic index of plasma combined with lactate-to-albumin ratio for in-hospital mortality in patients with acute myocardial infarction complicated by cardiogenic shock"],"prefix":"10.3389","volume":"13","author":[{"given":"Yinsheng","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Cardiac Care Unit (CCU), Renmin Hospital, Hubei University of Medicine","place":["Shiyan, Hubei, 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