{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:02:27Z","timestamp":1779692547015,"version":"3.53.1"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the safety, hemodynamic efficacy, and short-term outcomes of CorVad mechanical circulatory support as a bridge to left ventricular assist device (LVAD) therapy for cardiogenic shock and the changes in related hemolysis indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed three patients with Society for Cardiovascular Angiography and Interventions (SCAI) stage D Cardiogenic shock (CS) admitted between November 2024 and May 2025 to the First Affiliated Hospital of Anhui Medical University. All received CorVad support and were bridged to LVAD. Hemodynamic parameters, short-term prognosis, and dynamic changes in hemoglobin (Hb), hematocrit (Hct) and Indirect bilirubin within 24\u2005h post-implantation were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CorVad support led to rapid improvements in mean arterial pressure, cardiac output, and cardiac index, accompanied by a marked reduction in lactate. All three patients successfully underwent elective LVAD implantation without procedural complications or in-hospital mortality. All patients remained alive and ambulatory at 30-day and 3-month follow-up. Within 24\u2005h post-implantation, Hb, Hct declined modestly and indirect bilirubin levels have slightly increased, suggesting mild hemolysis or transient hemodilution, without severe hemolysis-related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CorVad provides effective and timely hemodynamic rescue in patients with CS, enabling safe transition to durable LVAD implantation, with favorable short-term prognosis. Serial monitoring of hemolysis-related indicators is required postoperatively to identify and manage potential hemolysis risks at an early stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1816772","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:03:54Z","timestamp":1779689034000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Corvad as a bridge to LVAD implantation in end-stage heart disease complicated by cardiogenic shock: a three-case series"],"prefix":"10.3389","volume":"13","author":[{"given":"Jianhao","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"451","DOI":"10.4244\/EIJ-D-20-01296","article-title":"Management of cardiogenic shock: cardiogenic shock","volume":"17","author":"Thiele","year":"2021","journal-title":"EuroIntervention"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.3390\/pharmaceutics15071935","article-title":"Nanosystems in cardiovascular medicine: advancements, applications, and future perspectives","volume":"15","author":"Omidian","year":"2023","journal-title":"Pharmaceutics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.21037\/cdt-20-283","article-title":"Mechanical circulatory support systems: evolution, the systems and outlook","volume":"11","author":"Hetzer","year":"2021","journal-title":"Cardiovasc Diagn Ther"},{"key":"B4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1177\/0391398818822267","article-title":"Mechanical circulatory support: 60 years of evolving knowledge","volume":"42","author":"Terzi","year":"2019","journal-title":"Int J Artif Organs"},{"key":"B5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.xjtc.2022.02.039","article-title":"Extracorporeal membrane oxygenation and left ventricular unloading: what is the evidence?","volume":"13","author":"Lorusso","year":"2022","journal-title":"JTCVS tech"},{"key":"B6","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1001\/jamainternmed.2015.0569","article-title":"Intra-aortic balloon pump therapy for acute myocardial infarction: a meta-analysis","volume":"175","author":"Ahmad","year":"2015","journal-title":"JAMA Intern Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"CD007398","DOI":"10.1002\/14651858.CD007398.pub3","article-title":"Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock","volume":"2015","author":"Unverzagt","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/j.jcin.2023.05.043","article-title":"Management of bleeding and hemolysis during percutaneous microaxial flow pump support: a practical approach","volume":"16","author":"Van Edom","year":"2023","journal-title":"Cardiovasc Interv"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1816772\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:03:55Z","timestamp":1779689035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1816772\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":8,"alternative-id":["10.3389\/fcvm.2026.1816772"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2026.1816772","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"article-number":"1816772"}}