{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:06:33Z","timestamp":1790139993816,"version":"4.0.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017959","name":"Health Commission of Hebei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017959","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to systematically evaluate the microstructure changes of the myocardium at the left atrium\u2013left atrial appendage (LA\u2013LAA) junction in patients with atrial fibrillation (AF)-related cardioembolic stroke, and to explore its potential role as an imaging marker associated with stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included four groups: AF-related cardioembolic stroke group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960), AF-non-stroke group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929), non-AF-stroke (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953), and non-AF-non-stroke (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953). All subjects underwent cardiac computed tomography examination. Myocardial thickness at the LA\u2013LAA junction was measured, and radiomics features were extracted. Radiomics features included first-order statistical features, shape features, and texture features. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to screen features, and a logistic regression model combining radiomics features and clinical parameters was constructed. Group comparisons were performed using t-tests or Mann\u2013Whitney U tests. The predictive ability of the model was evaluated with the receiver operating characteristic (ROC) curve, and a nomogram was used for risk assessment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with AF patients without stroke, patients with AF-related cardioembolic stroke significantly increased myocardial thickness at the LA\u2013LAA junction [7.1 (6.43\u20138.33)\u2005mm vs. 6.58\u2009\u00b1\u20091.45\u2005mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05]. In addition, multivariate logistic regression demonstrated that myocardial thickness was independently associated with AF-related cardioembolic stroke. Three radiomics features were selected by LASSO regression in AF-related cardioembolic stroke and non-AF-non-stroke patients, and a radiomics score (Rad-score) was generated. The Rad-score was statistically significant between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). The combined model incorporating Rad-score and clinical parameters achieved an area under curve (AUC) of 0.968 in the test cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both myocardial radiomics features and myocardial thickness at the LA\u2013LAA junction may serve as potential imaging markers associated with AF-related cardioembolic stroke. Their incremental value for stroke risk stratification beyond established clinical risk factors requires further validation in larger prospective cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1817530","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:46:22Z","timestamp":1790138782000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between myocardial radiomics features at the left atrium\u2013left atrial appendage junction and stroke risk in atrial fibrillation patients: a retrospective case\u2013control study"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiao-xuan","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, The Second Hospital of Hebei Medical University","place":["Shijiazhuang, 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