{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:19:01Z","timestamp":1788153541576,"version":"build-2803163510"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2005202"],"award-info":[{"award-number":["U2005202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020J01998"],"award-info":[{"award-number":["2020J01998"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2025J01118"],"award-info":[{"award-number":["2025J01118"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aortic dissection (AD) is a catastrophic cardiovascular emergency with high morbidity and mortality. Despite advances in diagnosis and treatment, its complex pathogenesis, optimal therapies, and postoperative complications remain major challenges. Although AD research has expanded substantially, quantitative analyses integrating global knowledge structures with molecular mechanisms remain limited. This study mapped the development, contributors, hotspots, and emerging frontiers of global AD research to support future investigation and clinical translation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>AD-related literature published from January 1, 2000, to December 31, 2025, was retrieved from the Web of Science Core Collection and Scopus. Excel, VOSviewer, CiteSpace, Scimago Graphica, and bibliometrix were used for bibliometric analyses, and a logistic growth model characterized publication trends. Single-cell RNA sequencing datasets GSE254132 and GSE213740 served as discovery and external-validation cohorts, respectively. Seurat, Harmony, donor-level pseudobulk differential expression, and exact donor-label permutation tests were applied. Differentially expressed genes were linked to target-specific PubMed trajectories to distinguish established AD genes from literature-sparse candidates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 5,170 publications were included. Output accelerated after 2010 and reached 712 articles in 2025. China produced the most publications, whereas the United States had the highest citation count and strongest international collaboration. Four convergent frontiers emerged: endovascular therapy, inflammation and vascular-wall remodeling, candidate molecular markers, and machine-learning-based prognosis. In GSE254132, AD was associated with vascular smooth muscle cell remodeling and a higher proportion of SPP1\u207a remodeling macrophages. GSE213740 reproduced the direction of this remodeling program and showed a smaller increase in SPP1\u207a macrophages despite compositional differences. During 2000\u20132025, PubMed indexed 1,483 publications on angiopoietin-like 4 (ANGPTL4) and 240 on matrix metalloproteinase 19 (MMP19) across biomedical fields. Output increased by 49.9% and 43.5%, respectively, in 2021\u20132025 versus 2016\u20132020. Record-level screening identified only two original AD-relevant publications for each target.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study maps the global structure and changing priorities of AD research and uses human single-cell data as a biological cross-check and candidate-prioritization layer. The combined evidence identifies ANGPTL4 and MMP19 as literature-sparse molecules that warrant mechanistic investigation, not as validated therapeutic targets. Independent cohorts and functional experiments are required before either molecule can be assigned diagnostic or therapeutic value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1822129","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:29:46Z","timestamp":1788150586000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging macro bibliometrics and micro molecular mechanisms: an integrated analysis of global aortic dissection research"],"prefix":"10.3389","volume":"13","author":[{"given":"Yunnan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Fujian Medical University Union Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixie","family":"He","sequence":"additional","affiliation":[{"name":"First Clinical Medical School, Southern Medical University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fujian Medical University Union Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangwan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Fujian Medical University Union Hospital","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.26635\/6965.6207","article-title":"A glimpse into the incidence and mortality of aortic dissection in aotearoa New Zealand","volume":"136","author":"Lim","year":"2023","journal-title":"N Z Med J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e17955","DOI":"10.1016\/j.heliyon.2023.e17955","article-title":"Global trends in research of acute type a aortic dissection: a bibliometric analysis from 2002 to 2022","volume":"9","author":"Qi","year":"2023","journal-title":"Heliyon"},{"key":"B3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1136\/heartjnl-2023-323042","article-title":"Temporal trends in mortality of aortic dissection and rupture in the UK, Japan, the USA and Canada","volume":"110","author":"Hibino","year":"2024","journal-title":"Heart"},{"key":"B4","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s11596-022-2662-9","article-title":"Aortic dissection research in China: analysis of studies funded by the national natural science foundation of China","volume":"43","author":"Yue","year":"2023","journal-title":"Curr Med Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e33160","DOI":"10.1097\/md.0000000000033160","article-title":"Hotspots and development frontiers of postoperative complications of ad: bibliometric analysis - a review","volume":"102","author":"Feng","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2371401","DOI":"10.1155\/2022\/2371401","article-title":"Noncoding rna in the regulation of acute aortic dissection: from profile to mechanism","volume":"2022","author":"Wei","year":"2022","journal-title":"Cardiovasc Ther"},{"key":"B7","doi-asserted-by":"publisher","first-page":"545","DOI":"10.22038\/abjs.2023.70791.331","article-title":"Recent trends and hotspots in knee arthroplasty: a bibliometric analysis and visualization study of the last five-year publications","volume":"11","author":"Poursalehian","year":"2023","journal-title":"Arch Bone Jt Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13019-025-03400-2","article-title":"Research progress and hotspot analysis of type B aortic dissection: a bibliometric analysis from 2004 to 2023","volume":"20","author":"Zhao","year":"2025","journal-title":"J Cardiothorac Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1436600","DOI":"10.3389\/fcvm.2024.1436600","article-title":"A bibliometric analysis of abdominal aortic aneurysm (2014\u22122024)","volume":"11","author":"Liu","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.joi.2018.09.002","article-title":"Google scholar, web of science, and scopus: a systematic comparison of citations in 252 subject categories","volume":"12","author":"Mart\u00edn-Mart\u00edn","year":"2018","journal-title":"J Informetr"},{"key":"B11","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/asi.20317","article-title":"Citespace ii: detecting and visualizing emerging trends and transient patterns in scientific literature","volume":"57","author":"Chen","year":"2006","journal-title":"J Am Soc Inf Sci Technol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: vosviewer, a computer program for bibliometric mapping","volume":"84","author":"Van Eck","year":"2010","journal-title":"Scientometrics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J Informetr"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.1097\/js9.0000000000000720","article-title":"Global trends and prospects in health economics of robotic surgery: a bibliometric analysis","volume":"109","author":"Peng","year":"2023","journal-title":"Int J Surg"},{"key":"B15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: ncbi gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"399","DOI":"10.3390\/biom13020399","article-title":"Single-Cell RNA-Seq analysis reveals macrophages are involved in the pathogenesis of human sporadic acute type A aortic dissection","volume":"13","author":"Zhang","year":"2023","journal-title":"Biomolecules"},{"key":"B17","doi-asserted-by":"publisher","first-page":"104608","DOI":"10.1016\/j.neubiorev.2022.104608","article-title":"Half a century of research on antipsychotics and schizophrenia: a scientometric study of hotspots, nodes, bursts, and trends","volume":"136","author":"Sabe","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"B18","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.jacc.2015.05.029","article-title":"Presentation, diagnosis, and outcomes of acute aortic dissection: 17-year trends from the international registry of acute aortic dissection","volume":"66","author":"Pape","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1161\/circinterventions.113.000463","article-title":"Endovascular repair of type B aortic dissection: long-term results of the randomized investigation of stent grafts in aortic dissection trial","volume":"6","author":"Nienaber","year":"2013","journal-title":"Circ Cardiovasc Interv"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1378\/chest.117.5.1271","article-title":"Epidemiology and clinicopathology of aortic dissection","volume":"117","author":"M\u00e9sz\u00e1ros","year":"2000","journal-title":"Chest"},{"key":"B21","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1378\/chest.122.1.311","article-title":"Clinical, diagnostic, and management perspectives of aortic dissection","volume":"122","author":"Khan","year":"2002","journal-title":"Chest"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1161\/circulationaha.112.000483","article-title":"Population-Based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the Oxford vascular study","volume":"127","author":"Howard","year":"2013","journal-title":"Circulation"},{"key":"B23","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1038\/ncpcardio1417","article-title":"Observational study of mortality risk stratification by ischemic presentation in patients with acute type a aortic dissection: the penn classification","volume":"6","author":"Augoustides","year":"2009","journal-title":"Nat Clin Pract Cardiovasc Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"Cd012992","DOI":"10.1002\/14651858.CD012992.pub2","article-title":"Endovascular versus open surgical repair for complicated chronic type B aortic dissection","volume":"12","author":"Jordan","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"B25","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.ejvs.2025.09.039","article-title":"Ten year clinical and aortic remodelling outcomes following endovascular repair of chronic type B aortic dissection","volume":"71","author":"Urick","year":"2025","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e010673","DOI":"10.1161\/circoutcomes.123.010673","article-title":"Acute aortic dissection: observational lessons learned from 11 000 patients","volume":"17","author":"Bossone","year":"2024","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"B27","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.ejvs.2023.05.015","article-title":"Editor\u2019s choice - trends in management and outcomes of type B aortic dissection: a report from the international registry of aortic dissection","volume":"66","author":"Trimarchi","year":"2023","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B28","doi-asserted-by":"publisher","first-page":"znaf300","DOI":"10.1093\/bjs\/znaf300","article-title":"Open surgery versus branched endovascular repair of the aortic arch in residual dissections after type a surgical repair","volume":"113","author":"Tinelli","year":"2026","journal-title":"Br J Surg"},{"key":"B29","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1097\/sla.0000000000006548","article-title":"Anatomical feasibility of endobentall strategies for management of acute type a aortic dissection","volume":"283","author":"Vall\u00e9e","year":"2024","journal-title":"Ann Surg"},{"key":"B30","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ejvs.2025.02.041","article-title":"Long term outcomes of endovascular treatment for retrograde ascending aortic dissection","volume":"70","author":"Peng","year":"2025","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B31","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ejvs.2025.04.044","article-title":"Inner branch off the shelf technology for chronic post-dissection thoraco-abdominal aneurysm with narrow true lumen: results of a European multicentre study","volume":"70","author":"Tinelli","year":"2025","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B32","doi-asserted-by":"publisher","first-page":"znaf227","DOI":"10.1093\/bjs\/znaf227","article-title":"Endovascular aortic arch repair with a triple branch arch device","volume":"112","author":"Grasso","year":"2025","journal-title":"Br J Surg"},{"key":"B33","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ejvs.2025.07.020","article-title":"Editor\u2019s choice - five year outcomes of the fabulous stent system in the management of complicated type B aortic dissection: a prospective multicentre study","volume":"71","author":"Hu","year":"2026","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B34","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1001\/jamacardio.2022.4187","article-title":"Initial thoracic endovascular aortic repair vs medical therapy for acute uncomplicated type B aortic dissection","volume":"8","author":"Weissler","year":"2023","journal-title":"JAMA Cardiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1148\/rg.220028","article-title":"Thoracic endovascular aortic repair for chronic type B aortic dissection: pre- and postprocedural imaging","volume":"42","author":"Shen","year":"2022","journal-title":"Radiographics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e018220","DOI":"10.1161\/circimaging.125.018220","article-title":"Steal phenomenon of thoracic false lumen: imaging insights from postdissection cases","volume":"18","author":"Ge","year":"2025","journal-title":"Circ Cardiovasc Imaging"},{"key":"B37","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ejvs.2024.04.041","article-title":"Post-Dissection thoraco-abdominal aortic aneurysm managed by fenestrated or branched endovascular aortic repair","volume":"68","author":"Gorgatti","year":"2024","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B38","doi-asserted-by":"publisher","first-page":"3577","DOI":"10.1111\/bph.70033","article-title":"Fibrin induces infiltration of macrophages and neutrophils via integrin \u0391m\u03b22 and triggers aortic dissection","volume":"182","author":"Li","year":"2025","journal-title":"Br J Pharmacol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s10020-024-00926-4","article-title":"Ace2 deficiency inhibits thoracic aortic dissection by enhancing Sirt3 mediated inhibition of inflammation and vscms phenotypic switch","volume":"30","author":"Jiang","year":"2024","journal-title":"Mol Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1007\/s11427-024-2693-5","article-title":"Role of macrophages in aortic dissection pathogenesis: insights from preclinical studies to translational prospective","volume":"67","author":"Li","year":"2024","journal-title":"Sci China Life Sci"},{"key":"B41","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1093\/eurheartj\/ehad534","article-title":"The activator protein-1 Complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture","volume":"45","author":"Luo","year":"2024","journal-title":"Eur Heart J"},{"key":"B42","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1161\/circulationaha.123.063332","article-title":"Epigenetic induction of smooth muscle cell phenotypic alterations in aortic aneurysms and dissections","volume":"148","author":"Chakraborty","year":"2023","journal-title":"Circulation"},{"key":"B43","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1161\/atvbaha.121.316237","article-title":"Large vessel cell heterogeneity and plasticity: focus in aortic aneurysms","volume":"42","author":"Jauhiainen","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1161\/atvbaha.122.317953","article-title":"Aortic cellular diversity and quantitative genome-wide association study trait prioritization through single-nuclear rna sequencing of the aneurysmal human aorta","volume":"42","author":"Chou","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e70147","DOI":"10.1002\/ctm2.70147","article-title":"Deficiency of Atf3 facilitates both angiotensin ii-induced and spontaneously formed aortic aneurysm and dissection development by activating cgas-sting pathway","volume":"15","author":"Du","year":"2025","journal-title":"Clin Transl Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12964-023-01120-5","article-title":"Single-cell rna sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm","volume":"21","author":"Cao","year":"2023","journal-title":"Cell Commun Signal"},{"key":"B47","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1161\/atvbaha.124.321421","article-title":"Sgk1-Mediated vascular smooth muscle cell phenotypic transformation promotes thoracic aortic dissection progression","volume":"45","author":"Leng","year":"2025","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1161\/atvbaha.124.321429","article-title":"Trem2\/tyrobp signaling protects against aortic dissection and rupture by inhibiting macrophage activation in mice","volume":"45","author":"Zhang","year":"2025","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.jare.2025.03.003","article-title":"From inflammation to remodelling: a novel Basp1(+) monocyte subset as a catalyst for acute aortic dissection","volume":"78","author":"He","year":"2025","journal-title":"J Adv Res"},{"key":"B50","doi-asserted-by":"publisher","first-page":"6592","DOI":"10.1038\/s41467-022-34469-1","article-title":"Jak2v617f mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm","volume":"13","author":"Al-Rifai","year":"2022","journal-title":"Nat Commun"},{"key":"B51","doi-asserted-by":"publisher","first-page":"3218","DOI":"10.3390\/cells11203218","article-title":"Targeted inhibition of matrix metalloproteinase-8 prevents aortic dissection in a murine model","volume":"11","author":"Zhang","year":"2022","journal-title":"Cells"},{"key":"B52","doi-asserted-by":"publisher","first-page":"107029","DOI":"10.1016\/j.phrs.2023.107029","article-title":"A proteome-wide screen identifies the calcium binding proteins, S100a8\/S100a9, as clinically relevant therapeutic targets in aortic dissection","volume":"199","author":"Jiang","year":"2024","journal-title":"Pharmacol Res"},{"key":"B53","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.advms.2024.09.006","article-title":"Angiopoietin-Like 4 facilitates human aortic smooth muscle cell phenotype switch and dysfunctions through the PI3\u2005K\/akt signaling in aortic dissection","volume":"69","author":"He","year":"2024","journal-title":"Adv Med Sci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s11748-020-01441-z","article-title":"Dysregulated long non-coding RNAs involved in regulation of matrix degradation during type-B aortic dissection pathogenesis","volume":"69","author":"Xu","year":"2021","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"B55","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.yjmcc.2025.02.004","article-title":"MMP19 In vascular smooth muscle cells protects against thoracic aortic aneurysm and dissection via the MMP19\/aggrecan\/wnt\/\u03b2-catenin axis","volume":"202","author":"Ma","year":"2025","journal-title":"J Mol Cell Cardiol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"905908","DOI":"10.3389\/fcvm.2022.905908","article-title":"Prediction nomogram for postoperative 30-day mortality in acute type a aortic dissection patients receiving total aortic arch replacement with frozen elephant trunk technique","volume":"9","author":"Lin","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B57","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1186\/s13019-024-02921-6","article-title":"A novel nomogram model to predict in-hospital mortality in patients with acute type a aortic dissection after surgery","volume":"19","author":"Zhou","year":"2024","journal-title":"J Cardiothorac Surg"},{"key":"B58","doi-asserted-by":"publisher","first-page":"E379","DOI":"10.1532\/hsf.3765","article-title":"Predictive factors for in-hospital preoperative rupture in hyperacute type a aortic dissection","volume":"24","author":"Tang","year":"2021","journal-title":"Heart Surg Forum"},{"key":"B59","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12872-021-01932-8","article-title":"Prognostic dynamic nomogram integrated with metabolic acidosis for in-hospital mortality and organ malperfusion in acute type B aortic dissection patients undergoing thoracic endovascular aortic repair","volume":"21","author":"Liu","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"B60","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s12931-025-03415-2","article-title":"Development and validation of a predictive model for postoperative acute respiratory distress syndrome in patients with type a aortic dissection based on the 2023 updated definition","volume":"26","author":"Tang","year":"2025","journal-title":"Respir Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"e34171","DOI":"10.1016\/j.heliyon.2024.e34171","article-title":"Machine learning-based model to predict severe acute kidney injury after total aortic arch replacement for acute type a aortic dissection","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1554579","DOI":"10.3389\/fmed.2025.1554579","article-title":"Predicting the risk of postoperative gastrointestinal bleeding in patients with type a aortic dissection based on an interpretable machine learning model","volume":"12","author":"Li","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"B63","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.avsg.2025.08.028","article-title":"Interpretable machine learning approaches for identification of acute aortic dissection in chest pain patients","volume":"122","author":"Li","year":"2026","journal-title":"Ann Vasc Surg"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.jtcvs.2024.09.019","article-title":"Enhanced machine learning models for predicting one-year mortality in individuals suffering from type a aortic dissection","volume":"169","author":"Zhang","year":"2025","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B65","doi-asserted-by":"publisher","first-page":"675431","DOI":"10.3389\/fcvm.2021.675431","article-title":"Predicting intensive care unit length of stay after acute type a aortic dissection surgery using machine learning","volume":"8","author":"Chen","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"B66","doi-asserted-by":"publisher","first-page":"3642","DOI":"10.1111\/jocs.16884","article-title":"Predicting postoperative hypoxemia risk factors in the patients after triple-branched stent graft implantation surgery with acute type a aortic dissection: a retrospective study","volume":"37","author":"Wang","year":"2022","journal-title":"J Card Surg"},{"key":"B67","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1186\/s12911-024-02770-2","article-title":"Prediction model of icu readmission in Chinese patients with acute type a aortic dissection: a retrospective study","volume":"24","author":"Ni","year":"2024","journal-title":"BMC Med Inform Decis Mak"},{"key":"B68","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s41747-023-00342-z","article-title":"Deep learning-aided extraction of outer aortic surface from ct angiography scans of patients with Stanford type B aortic dissection","volume":"7","author":"Kes\u00e4vuori","year":"2023","journal-title":"Eur Radiol Exp"},{"key":"B69","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1007\/s00330-025-12116-9","article-title":"Deep learning-driven false-lumen volumes predict adverse remodeling better than diameter in patients with residual aortic dissection on ct","volume":"36","author":"Fournel","year":"2025","journal-title":"Eur Radiol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"15266028241275828","DOI":"10.1177\/15266028241275828","article-title":"Radiomics-Based risk assessment correlates with outcomes in patients with acute type B aortic dissection undergoing thoracic endovascular repair","volume":"33","author":"Wu","year":"2024","journal-title":"J Endovasc Ther"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1681989","DOI":"10.3389\/fimmu.2025.1681989","article-title":"Identification of novel lipid metabolism-related biomarkers of aortic dissection by integrating single-cell rna sequencing analysis and machine learning algorithms","volume":"16","author":"Li","year":"2025","journal-title":"Front Immunol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"e45846","DOI":"10.1097\/md.0000000000045846","article-title":"Gene-Metabolite interactions in aortic dissection: insights from metabolic and single-cell analyses","volume":"104","author":"Yao","year":"2025","journal-title":"Medicine (Baltimore)"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.2147\/jir.S496007","article-title":"Development and validation of the systemic inflammatory response Index-based nomogram for predicting short-term adverse events in patients with acute uncomplicated type B aortic intramural hematoma","volume":"18","author":"Wang","year":"2025","journal-title":"J Inflamm Res"},{"key":"B74","doi-asserted-by":"publisher","first-page":"101329","DOI":"10.1016\/j.jacbts.2025.101329","article-title":"The reduction of comp serves as a predictor for warning of aortic dissection progression","volume":"10","author":"Li","year":"2025","journal-title":"JACC Basic Transl Sci"},{"key":"B75","doi-asserted-by":"publisher","first-page":"101346","DOI":"10.1016\/j.jacbts.2025.101346","article-title":"Cartilage oligomeric matrix protein, a potential biomarker for thoracic aortic dissection","volume":"10","author":"Khachigian","year":"2025","journal-title":"JACC Basic Transl Sci"},{"key":"B76","doi-asserted-by":"publisher","first-page":"133008","DOI":"10.1016\/j.ijcard.2025.133008","article-title":"A deep-learning system integrating electrocardiograms and laboratory indicators for diagnosing acute aortic dissection and acute myocardial infarction","volume":"423","author":"Wang","year":"2025","journal-title":"Int J Cardiol"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1822129\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:29:47Z","timestamp":1788150587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1822129\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":76,"alternative-id":["10.3389\/fcvm.2026.1822129"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2026.1822129","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"article-number":"1822129"}}