{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:08:30Z","timestamp":1779170910840,"version":"3.51.4"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Patent ductus arteriosus (PDA) that fails to close after birth can lead to a hemodynamically significant left to right shunt, resulting in pulmonary overcirculation and systemic hypoperfusion. Currently, ligation performed in the operating room or at the bedside in the neonatal intensive care unit (NICU) are options for surgical treatment of hsPDA that has failed to close following pharmacological intervention, and bedside ligation is considered an optimized approach for preterm and extremely low birth weight (ELBW) infants. However, numerous challenges regarding the treatment of neonatal hsPDA via bedside ligation remain unsolved. Recently, a successful bedside PDA ligation has been performed in the NICU of Sichuan Provincial People's Hospital to treat an ELBW neonate with a gestational age of 27\u2009+\u20091 weeks and a birth weight (BW) of 740\u2005g. Echocardiography conducted 2\u2005h after ligation revealed no distinct residual shunt at the great artery level. The infant's overall condition was favorable, and was successfully weaned from invasive mechanical ventilation on postoperative day 4. This article focuses on the diagnosis and comprehensive management of hsPDA in the presented case, synthesizing the findings with an extensive literature review to serve as a reference for managing such newborns with hsPDA.<\/jats:p>","DOI":"10.3389\/fcvm.2026.1824677","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:39:36Z","timestamp":1779169176000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Comprehensive management of bedside ligation of patent ductus arteriosus in an extremely low birth weight infant"],"prefix":"10.3389","volume":"13","author":[{"given":"Juan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine and Life Science of Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"Department of Pediatrics, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maojun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binzhi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3760\/cma.j.cn112140-20241210-00900","article-title":"Collaborating Group of Neonatal Cardiac Diseases, the Subspecialty Group of Cardiology, the Society of Pediatrics, Chinese Medical Association; Pediatric Cardiology Committee, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association; Editorial Board, Chinese Journal of Pediatrics. 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