{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:54:44Z","timestamp":1781758484500,"version":"3.54.5"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The previously published randomized trial comparing an extensive (targeting both clinical arrhythmia and bi-atrial arrhythmogenic substrate) and a limited (clinical arrhythmia only) approach to catheter ablation in patients with pulmonary hypertension did not demonstrate a significant difference in atrial tachyarrhythmia (ATA) recurrence during the one-year follow-up. This study presents the long-term results of these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants enrolled in the randomized trial (NCT04053361) were further followed and checked for ATA recurrence and all-cause mortality. Follow-up was primarily clinically driven, as the protocol for this secondary analysis was not fully prespecified<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 74 patients [41 males, median age 71 years (IQR: 61; 75)] were randomized to the extended (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200936) and limited (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200938) ablation groups and followed for a median of 45 and 41 months, respectively. The ATAs recurred in 22 (61%) patients after extended vs. 19 (50%) patients after limited ablation [hazard ratio (HR) 1.22, 95% confidence interval (CI): 0.66\u20132.3]. There were 21 (58%) deaths in the extended ablation group, and 22 (58%) patients died during follow-up after the limited ablation (HR: 0.74, 95% CI: 0.39\u20131.4). No recurrence of typical atrial flutter was noted among the 23 patients treated by the ablation of the cavo-tricuspid isthmus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Extensive catheter ablation in patients with pulmonary hypertension did not reduce ATA recurrence during the routine follow-up of more than 40 months. Cavo-tricuspid isthmus ablation appears effective in preventing recurrence of typical atrial flutter, even in this high-risk population. Given the exploratory nature of these analyses, further research is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1826752","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:33:33Z","timestamp":1781757213000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term follow-up of patients with pulmonary hypertension after catheter ablation of atrial fibrillation and atrial tachycardia"],"prefix":"10.3389","volume":"13","author":[{"given":"Milan","family":"Dusik","sequence":"first","affiliation":[{"name":"2nd Department of Medicine\u2014Department of Cardiovascular Medicine of the 1st Faculty of Medicine and General University Hospital in Prague","place":["Prague, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stepan","family":"Havranek","sequence":"additional","affiliation":[{"name":"2nd Department of 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