{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:06:24Z","timestamp":1784700384889,"version":"3.55.0"},"reference-count":125,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Heart failure is a significant disease that threatens human life and health globally, yet its pathogenesis remains incompletely understood, posing challenges for targeted treatment. The pleiotropic transcription factor c-Myc participates in the regulation of various biological processes and has been extensively studied in the field of oncology. Recent studies have increasingly indicated that c-Myc is also associated with the development of non-oncological diseases such as heart failure, playing a role in regulating key biological processes including cardiac hypertrophy, cardiac fibrosis, energy metabolism, and cardiac regeneration and repair in heart failure. This article reviews the latest research progress on c-Myc in heart failure, discussing its role in the pathogenesis of heart failure, its clinical significance, its potential as a therapeutic target, and the regulatory effects of traditional Chinese medicine on c-Myc. c-Myc is widely involved in the pathological process of the occurrence and development of HF, but its function is highly diverse. The specific effects of c-Myc vary considerably depending on the pathological context, disease stage, and its expression level. Current research on c-Myc is primarily at the preclinical stage. In order to facilitate the clinical translation of c-Myc as a potential therapeutic target for HF, future research may focus on precise targeting of c-Myc, optimal expression and timing, exploration of its mechanisms, and the potential of traditional Chinese medicine in modulating its effects.<\/jats:p>","DOI":"10.3389\/fcvm.2026.1832539","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:52:23Z","timestamp":1784699543000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["c-Myc: an emerging participant in heart failure"],"prefix":"10.3389","volume":"13","author":[{"given":"Yifeng","family":"Wu","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital","place":["Beijing, China"]},{"name":"Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital","place":["Beijing, China"]},{"name":"Department of Cardiovascular, Ordos Hospital of Traditional Chinese Medicine","place":["Ordos, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital","place":["Beijing, China"]},{"name":"Beijing Bei Zhong Asset Management Co. 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