{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:08:37Z","timestamp":1779253717147,"version":"3.51.4"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bioresorbable scaffolds aim to mitigate long-term complications of drug-eluting stents (DES). The bioresorbable magnesium scaffold Magmaris is an alternative, but its role in acute coronary syndrome (ACS) remains insufficiently studied. Therefore, we aimed to evaluate safety and efficacy of Magmaris in ACS and compare outcomes with DES.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Embase and Cochrane Central Register of Controlled Trials for randomized and observational studies reporting outcomes of Magmaris in ACS. Primary outcome was target-lesion failure (TLF) defined as composite of cardiac death (CD), target-vessel myocardial infarction (TV-MI) and target-lesion revascularization (TLR) at one year. Secondary outcomes included scaffold\/stent thrombosis (ST) and procedural success. Single-arm pooled event rates and pairwise comparisons were estimated using generalized linear mixed-effects models (GLMM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included four studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009622 patients; 322 Magmaris, 300 DES) for pairwise analysis. At one year, no statistically significant difference in TLF was observed between Magmaris and DES (7.5% vs. 5.3%, OR 1.53, 95% CI 0.79\u20132.97;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.21;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200954.7%), although confidence intervals were wide. TLR was significantly higher with Magmaris (6.8% vs. 3.0%, OR 2.63, 95% CI 1.17\u20135.90;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200910.7%), while TV-MI, CD and ST did not differ significantly between groups. Twelve studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091,391 patients) contributed single-arm analyses showing pooled 1-year incidence of TLF 4.97%, TLR 4.16% and ST 0.83%. Procedural success was 98.49% (95% CI 97.21\u201399.18;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200935.4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In ACS, Magmaris was associated with low observed ST rates, nevertheless, comparative safety and efficacy vs. DES remain uncertain due to limited and heterogeneous evidence. Higher TLR rates with Magmaris suggest that further technical improvements in next-generation magnesium scaffolds are needed before this strategy can be considered a robust alternative in ACS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1834712","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:34:38Z","timestamp":1779251678000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Magmaris bioresorbable magnesium scaffold in acute coronary syndromes: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Simon","family":"W\u00f6lbert","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, University Hospital Augsburg, University of Augsburg","place":["Augsburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo F. F.","family":"Escrihuela-Branz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, University Hospital Augsburg, University of Augsburg","place":["Augsburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie Gladys","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, University Hospital Augsburg, University of Augsburg","place":["Augsburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Patrignani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele","place":["Milan, Italy"]},{"name":"Department of Cardiovascular Medicine, Humanitas Clinical and Research Center IRCCS and Humanitas University","place":["Rozzano, Milano, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Chiarito","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele","place":["Milan, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Torzewski","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Oberallgaeu-Kempten","place":["Kempten, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip W. J.","family":"Raake","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, University Hospital Augsburg, University of Augsburg","place":["Augsburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Bongiovanni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, University Hospital Augsburg, University of Augsburg","place":["Augsburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.jacc.2019.11.058","article-title":"Stent-Related adverse events >1 year after percutaneous coronary intervention","volume":"75","author":"Madhavan","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1093\/eurheartj\/ehab280","article-title":"Long-term follow-up after ultrathin vs. Conventional 2nd-generation drug-eluting stents: a systematic review and meta-analysis of randomized controlled trials","volume":"42","author":"Madhavan","year":"2021","journal-title":"Eur Heart J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e003785","DOI":"10.1161\/CIRCINTERVENTIONS.116.003785","article-title":"Failure mechanisms and neoatherosclerosis patterns in very late drug-eluting and bare-metal stent thrombosis","volume":"9","author":"Nakamura","year":"2016","journal-title":"Circ Cardiovasc Interv"},{"key":"B4","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1161\/01.CIR.102.4.399","article-title":"Initial and 6-month results of biodegradable poly-l-lactic acid coronary stents in humans","volume":"102","author":"Tamai","year":"2000","journal-title":"Circulation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1080\/17425247.2025.2495043","article-title":"Drug-eluting resorbable coronary scaffolds: a review of recent advances","volume":"22","author":"Vanoverbeke","year":"2025","journal-title":"Expert Opin Drug Deliv"},{"key":"B6","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.carrev.2024.11.003","article-title":"Five-year clinical outcomes of STEMI patients treated with a pre-specified bioresorbable vascular scaffold implantation technique: final results of the BVS STEMI STRATEGY-IT","volume":"78","author":"Moscarella","year":"2025","journal-title":"Cardiovasc Revasc Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.4244\/EIJ-D-18-01080","article-title":"Angiographic and clinical outcomes of STEMI patients treated with bioresorbable or metallic everolimus-eluting stents: a pooled analysis of individual patient data","volume":"15","author":"Cassese","year":"2020","journal-title":"EuroIntervention"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijcard.2023.04.029","article-title":"Long-term outcomes of patients treated with sirolimus-eluting resorbable magnesium scaffolds: insights from the SHERPA-MAGIC study","volume":"383","author":"Pompei","year":"2023","journal-title":"Int J Cardiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"232","DOI":"10.4244\/EIJ-D-22-01069","article-title":"One- and two-year clinical outcomes of treatment with resorbable magnesium scaffolds for coronary artery disease: the prospective, international, multicentre BIOSOLVE-IV registry","volume":"19","author":"Wlodarczak","year":"2023","journal-title":"EuroIntervention J Eur Collab Work Group Interv Cardiol Eur Soc Cardiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.carrev.2016.05.001","article-title":"In vitro performance investigation of bioresorbable scaffolds\u2014standard tests for vascular stents and beyond","volume":"17","author":"Schmidt","year":"2016","journal-title":"Cardiovasc Revasc Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e004762","DOI":"10.1161\/CIRCINTERVENTIONS.116.004762","article-title":"Comparison of acute thrombogenicity for metallic and polymeric bioabsorbable scaffolds","volume":"10","author":"Waksman","year":"2017","journal-title":"Circ Cardiovasc Interv"},{"key":"B12","doi-asserted-by":"publisher","first-page":"S969","DOI":"10.21037\/jtd.2017.06.136","article-title":"Are acute coronary syndromes an ideal scenario for bioresorbable vascular scaffold implantation?","volume":"9","author":"Moscarella","year":"2017","journal-title":"J Thorac Dis"},{"key":"B13","doi-asserted-by":"crossref","DOI":"10.1002\/9781119536604","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2019"},{"key":"B14","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Br Med J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"828","DOI":"10.4244\/EIJV12I7A137","article-title":"Magmaris preliminary recommendation upon commercial launch: a consensus from the expert panel on 14 April 2016","volume":"12","author":"Fajadet","year":"2016","journal-title":"EuroIntervention"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.11124\/JBISRIR-D-19-00099","article-title":"Methodological quality of case series studies: an introduction to the JBI critical appraisal tool","volume":"18","author":"Munn","year":"2020","journal-title":"JBI Evid Synth"},{"key":"B17","doi-asserted-by":"publisher","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"Br Med J"},{"key":"B18","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"Rob 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"Br Med J"},{"key":"B19","doi-asserted-by":"publisher","first-page":"g5630","DOI":"10.1136\/bmj.g5630","article-title":"A GRADE working group approach for rating the quality of treatment effect estimates from network meta-analysis","volume":"349","author":"Puhan","year":"2014","journal-title":"Br Med J"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1161\/CIRCULATIONAHA.117.029289","article-title":"Standardized End point definitions for coronary intervention trials: the academic research consortium-2 consensus document","volume":"137","author":"Garcia-Garcia","year":"2018","journal-title":"Circulation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","article-title":"Clinical End points in coronary stent trials","volume":"115","author":"Cutlip","year":"2007","journal-title":"Circulation"},{"key":"B22","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1097\/EDE.0000000000001232","article-title":"Meta-analysis of proportions using generalized linear mixed models","volume":"31","author":"Lin","year":"2020","journal-title":"Epidemiology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"Br Med J"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1002\/sim.7588","article-title":"A comparison of seven random-effects models for meta-analyses that estimate the summary odds ratio","volume":"37","author":"Jackson","year":"2018","journal-title":"Stat Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1002\/sim.1187","article-title":"How should meta-regression analyses be undertaken and interpreted?","volume":"21","author":"Thompson","year":"2002","journal-title":"Stat Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1161\/CIRCULATIONAHA.119.043467","article-title":"Magnesium-Based resorbable scaffold versus permanent metallic sirolimus-eluting stent in patients with ST-segment elevation myocardial infarction: the MAGSTEMI randomized clinical trial","volume":"140","author":"Sabat\u00e9","year":"2019","journal-title":"Circulation"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s10557-021-07258-z","article-title":"Comparison of a bioresorbable, magnesium-based sirolimus-eluting stent with a permanent, everolimus-eluting metallic stent for treating patients with acute coronary syndrome: the PRAGUE-22 study","volume":"36","author":"Tou\u0161ek","year":"2022","journal-title":"Cardiovasc Drugs Ther"},{"key":"B29","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.carrev.2022.05.028","article-title":"Magmaris resorbable magnesium scaffold versus conventional drug-eluting stent in ST-segment elevation myocardial infarction: 1-year results of a propensity-score-matching comparison","volume":"43","author":"de Hemptinne","year":"2022","journal-title":"Cardiovasc Revascularization Med Mol Interv"},{"key":"B30","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5114\/aic.2024.136901","article-title":"Magnesium bioresorbable scaffold (Magmaris) versus polymer biodegradable ultrathin drug-eluting stent (ultimaster) in acute coronary syndrome. Mid-term outcomes (2 years)","volume":"20","author":"W\u0142odarczak","year":"2024","journal-title":"Postepy W Kardiologii Interwencyjnej Adv Interv Cardiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.3390\/biomedicines11041150","article-title":"Bioresorbable magnesium-based stent: real-world clinical experience and feasibility of follow-up by coronary computed tomography: a new window to Look at new scaffolds","volume":"11","author":"Ghafari","year":"2023","journal-title":"Biomedicines"},{"key":"B32","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.carrev.2023.06.022","article-title":"Comparison of acute versus stable coronary syndrome in patients treated with the Magmaris scaffold: Two-year results from the Magmaris multicenter Italian registry","volume":"57","author":"Galli","year":"2023","journal-title":"Cardiovasc Revasc Med Mol Interv"},{"key":"B33","first-page":"202","article-title":"Drug-Eluting resorbable magnesium scaffold implantation in ST-segment elevation myocardial infarction: a pilot study","volume":"30","author":"de Hemptinne","year":"2018","journal-title":"J Invasive Cardiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000499536","article-title":"Sirolimus-Eluting magnesium resorbable scaffold implantation in patients with acute myocardial infarction","volume":"142","author":"Ielasi","year":"2019","journal-title":"Cardiology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.carrev.2021.12.003","article-title":"Optical coherence tomography- versus angiography-guided magnesium bioresorbable scaffold implantation in NSTEMI patients","volume":"40","author":"Fallesen","year":"2022","journal-title":"Cardiovasc Revasc Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"274","DOI":"10.24875\/RECICE.M21000216","article-title":"Long-term (> 12 months) single-center registry of Magmaris implantation in the acute coronary syndrome setting","volume":"3","author":"Bay\u00f3n","year":"2021","journal-title":"REC Interv Cardiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/S0140-6736(19)31877-X","article-title":"Biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents in patients with ST-segment elevation myocardial infarction (BIOSTEMI): a single-blind, prospective, randomised superiority trial","volume":"394","author":"Iglesias","year":"2019","journal-title":"Lancet"},{"key":"B38","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.jcin.2018.04.014","article-title":"Comparison of a novel biodegradable polymer sirolimus-eluting stent with a durable polymer everolimus-eluting stent: 5-year outcomes of the randomized BIOFLOW-II trial","volume":"11","author":"Lef\u00e8vre","year":"2018","journal-title":"JACC Cardiovasc Interv"},{"key":"B39","doi-asserted-by":"publisher","first-page":"974957","DOI":"10.3389\/fcvm.2022.974957","article-title":"Bioresorbable scaffolds vs. drug-eluting stents for patients with myocardial infarction: a systematic review and meta-analysis of randomized clinical trials","volume":"9","author":"Liu","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1136\/heartjnl-2013-304933","article-title":"Incidence and predictors of restenosis after coronary stenting in 10 004 patients with surveillance angiography","volume":"100","author":"Cassese","year":"2014","journal-title":"Heart Br Card Soc"},{"key":"B41","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jacc.2023.05.003","article-title":"5-Year Outcomes after bioresorbable coronary scaffolds implanted with improved technique","volume":"82","author":"Stone","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"E69","DOI":"10.1002\/ccd.29557","article-title":"Long-term clinical, angiographic, and optical coherence tomography findings of Mg-based bioresorbable scaffold in patients with acute coronary syndrome","volume":"98","author":"Guti\u00e9rrez-Barrios","year":"2021","journal-title":"Catheter Cardiovasc Interv Off J Soc Card Angiogr Interv"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1016\/j.jacc.2017.10.010","article-title":"3-Year Clinical outcomes with everolimus-eluting bioresorbable coronary scaffolds: the ABSORB III trial","volume":"70","author":"Kereiakes","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"B44","author":"Biotronik","year":"2024"},{"key":"B45","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.jclinepi.2014.03.003","article-title":"In meta-analyses of proportion studies, funnel plots were found to be an inaccurate method of assessing publication bias","volume":"67","author":"Hunter","year":"2014","journal-title":"J Clin Epidemiol"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1834712\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:34:48Z","timestamp":1779251688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2026.1834712\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":45,"alternative-id":["10.3389\/fcvm.2026.1834712"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2026.1834712","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"article-number":"1834712"}}