{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:00:37Z","timestamp":1785477637826,"version":"3.56.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the relationship between red blood cell distribution width (RDW) and perioperative lower-extremity deep vein thrombosis (DVT) in patients aged 18\u201375 years with lower-limb fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>From February 2021 to February 2023, we included 766 patients aged 18\u201375 years with lower-limb fractures. Univariate and multivariable analyses were used to investigate the association between RDW and DVT. The discriminatory ability and cohort-specific exploratory cut-off values of RDW were evaluated using receiver operating characteristic (ROC) curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ROC curve analysis identified cohort-specific exploratory cut-off values of 43.9 fL for RDW standard deviation (RDW-SD) and 13.2% for RDW coefficient of variation (RDW-CV), and RDW-SD showed better discrimination than RDW-CV (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). In the adjusted analyses, RDW-SD \u226543.9 fL [adjusted odds ratio (aOR), 3.372;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001], RDW-CV \u226513.2% (aOR, 2.556;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), advanced age (aOR, 1.054;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), higher platelet count (PLT; per 10\u2009\u00d7\u200910\u2079\/L increase: aOR, 1.115;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.010), and Hb &amp;lt;120\u2005g\/L (aOR, 1.785;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) were independently associated with perioperative DVT. Significant differences in age, fracture site, DVT, diabetes, cancer, and Hb &amp;lt;120\u2005g\/L were observed between the RDW-SD \u226543.9 fL and RDW-SD &amp;lt;43.9 fL groups (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Advanced age, Hb &amp;lt;120\u2005g\/L, higher PLT, RDW-SD \u226543.9 fL, and RDW-CV \u226513.2% were independently associated with perioperative DVT in patients aged 18\u201375 years with lower-limb fractures. RDW-SD showed better discrimination than RDW-CV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1841161","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:37:39Z","timestamp":1785476259000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between red blood cell distribution width and deep vein thrombosis in patients with lower limb fractures"],"prefix":"10.3389","volume":"13","author":[{"given":"Shuai","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Traumatic Orthopedics, Honghui Hospital, Xi\u2019an Jiaotong University","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfei","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics, Honghui Hospital, Xi\u2019an Jiaotong University","place":["Xi\u2019an, Shaanxi, 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University","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics, Honghui Hospital, Xi\u2019an Jiaotong University","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics, Honghui Hospital, Xi\u2019an Jiaotong University","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical College of Yan'an University","place":["Yan'an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopedics, Honghui Hospital, Xi\u2019an Jiaotong 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