{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:59:20Z","timestamp":1780981160821,"version":"3.54.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thoracic endovascular aortic repair (TEVAR) is the cornerstone treatment for type B aortic dissection (TBAD), but delayed discharge and mid-term major adverse events (MAEs) remain important clinical challenges. This single-center retrospective cohort study aimed to explore the associations of preoperative exercise tolerance, nutritional and inflammatory markers with short-term and mid-term outcomes in patients undergoing thoracic endovascular aortic repair (TEVAR) for type B aortic pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study enrolled 300 consecutive patients who underwent TEVAR for type B aortic pathology (type B acute aortic syndrome, B-AAS) between 2015 and 2020. The study population included three distinct entities: classic TBAD, intramural hematoma (IMH), and penetrating atherosclerotic ulcer (PAU), neither of which are regarded as subtypes of aortic dissection. Preoperative exercise tolerance was assessed by 6-minute walking distance (6MWD) and hand grip strength (HGS), together with geriatric nutritional risk index (GNRI), neutrophil-to-lymphocyte ratio (NLR), and activated partial thromboplastin time (APTT). Primary outcomes were delayed discharge and mid-term MAEs. Delayed discharge was explicitly defined as postoperative hospital stay &amp;gt;10 days, and mid-term major adverse events (MAEs) were recorded during follow-up. Univariate and multivariate regression analyses were performed to identify factors independently associated with outcomes, and interaction analyses were further conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Delayed discharge occurred in 18 (6.0%) patients and mid-term MAEs in 38 (12.7%). Independent predictors of delayed discharge included elevated APTT and NLR, and decreased GNRI, 6MWD, and HGS. The nomogram showed good discrimination (AUC: 0.84). Low 6MWD combined with low GNRI or high NLR synergistically increased the risks of delayed discharge and MAEs (both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Restricted cubic spline analyses confirmed linear dose-response relationships.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative exercise tolerance, nutritional status, and inflammatory biomarkers are independent correlative predictors of short-term and mid-term adverse outcomes after TEVAR. Combined assessment of these simple non-invasive indicators may assist preoperative clinical risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1844883","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:29:32Z","timestamp":1780979372000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative exercise tolerance, nutritional-inflammatory markers, and outcomes after TEVAR for type B aortic pathology"],"prefix":"10.3389","volume":"13","author":[{"given":"Haiyan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Nantong First People\u2019s Hospital","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibing","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Nantong First People\u2019s 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