{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:02:20Z","timestamp":1793160140846,"version":"4.5.0"},"reference-count":177,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>\n                    Acute myocardial infarction (AMI) triggers a coordinated inflammatory and reparative response that determines infarct healing, ventricular remodeling, and long-term cardiac function. Nuclear factor-kappa B (NF-\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B) signaling is a central regulator of this process, but its role is highly context dependent. Early NF-\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B activation contributes to danger-signal recognition, immune-cell recruitment, and clearance of necrotic myocardium, whereas sustained activation promotes unresolved inflammation, cardiomyocyte death, fibroblast activation, and adverse ventricular remodeling. This dual function partly explains why experimental studies of NF-\u03baB modulation in AMI have generated heterogeneous and sometimes conflicting results. In this review, we summarize the upstream triggers, temporal dynamics, cell-type-specific actions, and therapeutic implications of NF-\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B signaling in AMI. We also discuss the challenges of broad NF-\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B inhibition and highlight the need for temporally controlled and cell-selective strategies that preserve reparative inflammation while limiting chronic inflammatory injury and heart failure progression.\n                  <\/jats:p>","DOI":"10.3389\/fcvm.2026.1847945","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:39:05Z","timestamp":1784007545000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["NF-\u03baB signaling in acute myocardial infarction: pathophysiology, inflammation, and therapeutic implications"],"prefix":"10.3389","volume":"13","author":[{"given":"Yiyao","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Yixing People's Hospital","place":["Yixing City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Yixing People's Hospital","place":["Yixing City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1097\/00019501-200209000-00006","article-title":"Mitral regurgitation following acute myocardial infarction","volume":"13","author":"Birnbaum","year":"2002","journal-title":"Coron Artery Dis"},{"key":"B2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1148\/radiol.2021203208","article-title":"Acute microstructural changes after ST-segment elevation myocardial infarction assessed with diffusion tensor imaging","volume":"299","author":"Das","year":"2021","journal-title":"Radiology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/S0002-9149(84)80074-0","article-title":"Mechanisms contributing to precipitation of unstable angina and acute myocardial infarction: implications regarding therapy","volume":"54","author":"Epstein","year":"1984","journal-title":"Am J Cardiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1002\/ccd.28455","article-title":"Technical consideration in acute myocardial infarction with cardiogenic shock: a review of antithrombotic and PCI therapies","volume":"95","author":"Marquis-Gravel","year":"2020","journal-title":"Catheter Cardiovasc Interv"},{"key":"B5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-3-642-72497-8_10","article-title":"\u201cCardioprotection\u201d by ACE-inhibitors in acute myocardial ischemia and infarction?","author":"Przyklenk","year":"1993","journal-title":"Basic Res Cardiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.pcad.2024.01.017","article-title":"The spectrum of post-myocardial infarction care: from acute ischemia to heart failure","volume":"82","author":"Akhtar","year":"2024","journal-title":"Prog Cardiovasc Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.59249\/LSWK8578","article-title":"Arrhythmias after acute myocardial infarction","volume":"96","author":"Frampton","year":"2023","journal-title":"Yale J Biol Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1161\/01.CIR.90.2.1033","article-title":"Pathogenesis of acute myocardial infarction. 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