{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:50:23Z","timestamp":1782190223619,"version":"3.54.5"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oxidative stress is an early mediator of ethanol\u2013induced cardiorenal injury and dysfunction. The enzyme nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays a key role in the generation of reactive oxygen species (ROS) triggered by ethanol. In certain tissues, the pro\u2013oxidative and pro\u2013inflammatory effects of ethanol occur via activation of mineralocorticoid receptors (MR). We hypothesized that MR blockade would prevent the redox imbalance induced by ethanol during the early stages of cardiac and renal changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Male Wistar Hannover rats were treated with ethanol for five weeks. The contribution of the MR pathway to the cardiorenal effects of ethanol were evaluated with potassium canrenoate, an antagonist of the MR (MRA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Blockade of MR prevented the increase in lipoperoxidation and superoxide (O\n                      <jats:sub>2<\/jats:sub>\n                      \u2022\n                      <jats:sup>\u2212<\/jats:sup>\n                      ) levels in the left ventricle and renal cortex of ethanol-treated rats. Increased concentrations of hydrogen peroxide (H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      ) were detected in the renal cortex, but not in the left ventricle of ethanol-treated rats, and treatment with the MRA prevented this response. Ethanol augmented cardiac levels of thromboxane (TX)B\n                      <jats:sub>2<\/jats:sub>\n                      , a stable metabolite of TXA\n                      <jats:sub>2<\/jats:sub>\n                      and the renal concentration of prostaglandin (PG)E\n                      <jats:sub>2<\/jats:sub>\n                      . These responses were abrogated by MR blockade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The MR pathway mediates pro-oxidative effects in the early stages of ethanol-induced cardiorenal dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1855068","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:34:04Z","timestamp":1782189244000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mineralocorticoid receptors are implicated in the initial steps of the cardiorenal damage induced by ethanol"],"prefix":"10.3389","volume":"13","author":[{"given":"Thales M. H.","family":"Dourado","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP) , \/","place":["Ribeir\u00e3o Preto, Brazil"]},{"name":"Departamento de Ci\u00eancias BioMoleculares, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, USP , \/","place":["Ribeir\u00e3o Preto, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo F.","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Farmacologia, Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo (USP) , \/","place":["Ribeir\u00e3o Preto, Brazil"]},{"name":"Departamento de Ci\u00eancias BioMoleculares, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, USP , \/","place":["Ribeir\u00e3o Preto, 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