{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:18:13Z","timestamp":1783491493246,"version":"3.55.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMS25H070001"],"award-info":[{"award-number":["LMS25H070001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY172"],"award-info":[{"award-number":["2022KY172"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The convergence of viral infection, autoimmune thyroid disease, and cardiovascular vulnerability may create a \u201ctriple systemic stress\u201d predisposing to Takotsubo cardiomyopathy (TTS). We describe a case illustrating this potential pathophysiological triad.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A previously healthy 21-year-old male presented with sinus tachycardia, anterior ST-segment elevation on preoperative Electrocardiogram (ECG), and regional wall motion abnormalities on echocardiography two weeks after SARS-CoV-2 infection. Emergency coronary angiography ruled out myocardial infarction and coronary stenosis. Clinical features suggested thyrotoxicosis, confirmed by biochemical and imaging studies. Cardiac magnetic resonance demonstrates subendocardial hypoperfusion in the interventricular septum accompanied by abnormal myocardial motion. Treatment with methimazole and beta-blockers led to resolution of cardiac dysfunction and gradual normalization of thyroid function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case report describes a temporal association among SARS-CoV-2 infection, exacerbation of autoimmune thyroid dysfunction, and Takotsubo syndrome. The virus may contribute to Graves' disease exacerbation through immune-inflammatory mechanisms, while potentially inducing myocardial stress via cytokine-mediated pathways. These converging factors\u2014combined with thyrotoxicosis-related catecholamine sensitivity\u2014may act synergistically to increase TTS susceptibility. Clinically, thyroid evaluation may be considered in COVID-19 patients presenting with cardiac symptoms, and an integrated management approach addressing viral, endocrine, and cardiovascular aspects could be beneficial. The precise interconnections among these factors remain speculative and warrant further investigation in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1862540","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:54:21Z","timestamp":1783490061000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Takotsubo cardiomyopathy concurrent with hyperthyroidism following COVID-19\u2014a case report and literature review"],"prefix":"10.3389","volume":"13","author":[{"given":"Liya","family":"Lin","sequence":"first","affiliation":[{"name":"Center for Basic Research, Second Affiliated Hospital, School of Medicine, Zhejiang University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, University of California","place":["San Francisco, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyue","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, The Second Affiliated Hospital School of Medicine, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, 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