{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:49:39Z","timestamp":1782103779205,"version":"3.54.5"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background\/aims<\/jats:title>\n                    <jats:p>Left ventricular (LV) remodeling after acute myocardial infarction (AMI) is a key determinant of long-term outcomes. However, it remains unclear how LV geometry and systolic function interact to influence prognosis in real-world populations. We investigated the combined prognostic impact of LV dilatation and systolic dysfunction in patients with AMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 19,664 patients with AMI from nationwide Korean multicenter registries. LV geometry-function phenotypes were defined according to LV end-diastolic dimension (LVEDD \u226553\u2005mm for dilatation) and LV ejection fraction (LVEF \u226450% for reduced systolic function), and categorized as non-dilated\/preserved (group A), dilated\/preserved (group B), non-dilated\/reduced (group C), and dilated\/reduced (group D). The primary endpoint was 3-year major adverse cardiac and cerebrovascular events (MACCE), defined as cardiac death, non-fatal myocardial infarction, unplanned revascularization, cerebrovascular accident, and cardiovascular readmission. Associations between baseline geometry-function phenotypes and outcomes were assessed using multivariable Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence of MACCE increased stepwise from group A to D (13.2%, 13.5%, 16.8%, and 21.9%, respectively). In fully adjusted analyses, LV dilatation was not associated with increased risk in patients with preserved LVEF [group B vs. group A: hazard ratio (HR), 1.13; 95% confidence interval, 0.99\u20131.29]. In contrast, LV dilatation was associated with a higher risk when accompanied by reduced LVEF [group C: HR, 1.12 (1.01\u20131.24); group D: HR, 1.44 (1.29\u20131.60)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prognostic significance of LV dilatation after AMI depends on underlying systolic function. While LV dilatation alone may reflect a compensatory process in preserved LVEF, its presence in reduced LVEF identifies a high-risk phenotype. An integrated assessment of LV geometry and function may provide complementary risk stratification beyond conventional LVEF-based assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2026.1863946","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:32:29Z","timestamp":1782102749000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated left ventricular geometry\u2013function phenotypes and long-term outcomes after acute myocardial infarction"],"prefix":"10.3389","volume":"13","author":[{"given":"Seonmin","family":"Park","sequence":"first","affiliation":[{"name":"Department of Cardiology, Presbyterian Medical Center","place":["Jeonju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chonnam National University 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Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chonnam National University Hospital","place":["Gwangju, Republic of Korea"]},{"name":"Department of Cardiology, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Hoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chonnam National University Hospital","place":["Gwangju, Republic of Korea"]},{"name":"Department of Cardiology, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chonnam National University Hospital","place":["Gwangju, Republic of Korea"]},{"name":"Department of Cardiology, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doo Sun","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chonnam National University Hospital","place":["Gwangju, Republic of Korea"]},{"name":"Department of Cardiology, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chonnam National University Hospital","place":["Gwangju, Republic of Korea"]},{"name":"Department of Cardiology, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngkeun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chonnam National University Hospital","place":["Gwangju, Republic of Korea"]},{"name":"Department of Cardiology, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chonnam National University Hospital","place":["Gwangju, Republic of Korea"]},{"name":"Department of Cardiology, Chonnam National University Medical School","place":["Gwangju, Republic of Korea"]},{"name":"Department of Cardiology, Gwangju Veterans Hospital","place":["Gwangju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Pil","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Presbyterian Medical Center","place":["Jeonju, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay 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